Even more food-for-thought:
are BOTH semi-synthetic opioids
! *giggle* Hydro is made from codeine
, whereas oxy is made from just thebaine (thebaine, for those who don't know, is a naturally occurring alkaloid
from the opium
poppy (Papaver Somniferum), but it's not a "fun" one & actually has a bit of stimulating qualities to it; this is the basis of my theory that people find oxy more "uplifting" or "stimulating" than hydro or morphine
, as catseye mentioned, is completely synthetic (made up from stuff not related to the opium poppy at all); methadone
is also completely synthetic.
We now conclude your lesson today, brought to you by kailey_elise & catseye.
Also want to mention, tolerance is a tricky thing, and not everything is cross-tolerant, even though they are all opioids. I forget what the "official" term for this phenomenon is, but it's well known that someone can take Xmg of their Drug
of Choice everyday in the same place, but then they go to a different place one day, take the same amount of their DoC
as usual and overdose. Something about your body habituating to the spot, and it "gets ready" for the drug; when taking the drug in a different spot, your body doesn't have those "cues" to go by, thus isn't "ready" for the dose, and goes over. Weird shit, eh? Just one of the many ways a tolerant person can overdose; one is NEVER "safe from overdose" unless they aren't doing drugs
, simple as that. What if there was a "hot spot" in a patch one day, or doG-forbid, the company fucked up and put the amount for a 100mcg patch on a 25mcg patch (crazy shit happens); nothing's foolproof. Just sayin'.
It would be AWESOME if you lived near a city that is in the Narcan Pilot Program; various needle exchanges are handing out nasal Narcan just in case someone ODs, so they can be brought back (it's supposed to be "bring them back before the ambulance comes, but...eh, doesn't always work that way in practice, I'm told.
); sometimes you can get a doctor who prescribes you opioids to prescribe you a kit, too. http://www.harmreduction.org
lists many Needle Exchange/Syringe Access Programs in the USA, Canada & Mexico; one could call their local one to see what they may offer.
Sorry, this is all just "general good advice" for opioid
Sorry to hear your buddy's trials with various RoA (Routes of Administration
) has been basically a bust. Did he still have trouble even when attempting smoking from a sober state? Part of what sucks is that there's a learning curve to smoking, and people don't always have access to the extra supplies needed that might get fucked up during the learning process.
If willing to go VERY VERY slowly & titrate up, your buddy could perhaps follow the instructions for prepping a patch for IV use, but instead plug it (stick it up the ass); this is a VERY effective method, practically right up there with IV use - of course, it comes with many of the same risks as IV use as well, which needs to be kept in mind. They could also try prepping for IV use, but then letting all the liquid evaporate & scraping up the powder, then perhaps smoking (vaporising, really) the powder a little at a time, or maybe snorting
it? Naturally, many of these methods could have the effect of raising one's tolerance to the drug, so any need to be considered with much caution.
Has buddy looked into "potentiation methods" at all? Taking Tagament prior to use, or white grapefruit juice (frozen concentrate is best), or DXM
- the active ingredient in OTC cough medicine)? Co-administration of 1st generation anti-histamines (if you're from the US: diphenhydramine
(Benedryl) is OTC, promethazine (Phenergan) & hydroxyzine
(Vistaril) are easily available @ the doctor as non-habit-forming sleep aids) are supposed to work well with opioids (bonus: they're helpful by themselves if one happens to run out of opioids & is in withdrawal
); carisoprodol (Soma) is a muscle relaxant well-known to synergize EXTREMELY well with opioids (often TOO well - stick to just one Soma, MAYBE two, if mixing w/opioids!!!); tho it seems to work a bit better with opioids that are morphine based (natural or semi-synthetic), vs say, Fentanyl or methadone (it still works, though).
Perhaps check out the Saving Money Through Potentiation of Opiates
thread would garner some tips in this area, making the smaller amount your buddy has last longer, because he could use less of it or use the same amount & get a greater effect.
All the best, and encourage your friend to be as safe as humanly possible!