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Opiates & Opioids Opiates & Opioids.

 
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  #1  
Old 02-10-2010, 00:26
diffs diffs is offline
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Does combining opiates potentiate each other?

Swim has a fairly high opiate tolerance and uses most days. The sort of doses for each substance would be; Dihydrocodeine 1200mg, Morphine 250-300mg (orally), Oxycodone 160-220mg, Methadone 50-75mg, Diconal 100-120mg. Swim wouldn't really include codeine cause of the ceiling dose which isn't high enough to "do it" for Swim.

Swim Know's that mixing Benzo's and Opiates can potentiate each other so less of each is required. Also some anti-histamines, e.g Promethazine can increase the effect of opiates. Swim would like to know if mixing/combining opiates can potentiate each other. Swim has a decent amount of Dihydrocodeine and Oxycodone and is wondering if mixing the 2 would make each other stronger? If so, what sort of percentage reduction of each substance should one maybe try? As Swim said he would normally take 1200mg of DHC or around 160mg of Oxy.
Swim was thinking of combining both, but maybe starting off with around 25% of his usual dose of each substances a starting point and take it from there.

What do other Swimmers think?

SWIM NEEDS TO URGE THAT HE HAS A HIGH OPIATE TOLERANCE AND THE DOSES HE IS TALKING ABOUT ARE FOR HIMSELF. ANYONE WITH NO, LOW OR EVEN MEDIUM TOLERANCE SHOULD NOT TAKE ANYTHING LIKE THE DOSES SWIM IS TALKING ABOUT AS THEY WOULD/COULD BE DEADLY TO ANYONE WHO DOESN;T HAVE A HIGH TOLERANCE. IF YOU ARE NEW TO OPIATES ALWAYS START LOW AND SLOW AND WORK UP.

Swim apologises about writing in block capitals and understands it can be taken to be seen as shouting, but he just wanted to highlight the importance of the point.

Last edited by diffs; 02-10-2010 at 00:33.
  #2  
Old 02-10-2010, 00:49
Herbal Healer 019 Herbal Healer 019 is offline
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Re: Does combining opiates potentiate each other?

In my opinion, yes.

SWIM has always combined codeine with opioids like hydro/oxycodone under the assumption that because codeine induces cyp2d6 liver enzymes and hydro and oxy are metabolized into their stronger cousins hydromorphone and oxymorphone via cyp2d6 that the output of hydromorphone or oxymorphone would be greater as well as the amount of morphine being converted. Im not sure if this is actually true but every time SWIM has done this with codeine and hydrocodone or oxycodone his highs have been phenomenal and overpoweringly strong.

SWIM always found that combining opiates like dhc and codeine with opioids like oxycodone and hydrocodone always induces a stronger & much longer lasting high than either alone, if not because of the enzymatic pathways used to convert them into strong opioids is increased but simply because combining opioids is obviously going to lead to a stronger high.

The last time SWIM combined 120mg dhc with just 15mg hydrocodone and diphenhydramine (probably the culprit) he nodded out into his dinner plate in front of his dad like 10 times and didnt wake up for like 20 minutes (embarresing) each time & when he did this with oxycodone he had a simular experience although minus the dph.

I would also imagine the OD potential is greatly increased, so be careful & seriously whatever SWIY do start low
  #3  
Old 02-10-2010, 01:28
diffs diffs is offline
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Re: Does combining opiates potentiate each other?

Quote:
Originally Posted by Herbal Healer 019 View Post
In my opinion, yes.

SWIM has always combined codeine with opioids like hydro/oxycodone under the assumption that because codeine induces cyp2d6 liver enzymes and hydro and oxy are metabolized into their stronger cousins hydromorphone and oxymorphone via cyp2d6 that the output of hydromorphone or oxymorphone would be greater as well as the amount of morphine being converted. Im not sure if this is actually true but every time SWIM has done this with codeine and hydrocodone or oxycodone his highs have been phenomenal and overpoweringly strong.

SWIM always found that combining opiates like dhc and codeine with opioids like oxycodone and hydrocodone always induces a stronger & much longer lasting high than either alone, if not because of the enzymatic pathways used to convert them into strong opioids is increased but simply because combining opioids is obviously going to lead to a stronger high.

The last time SWIM combined 120mg dhc with just 15mg hydrocodone and diphenhydramine (probably the culprit) he nodded out into his dinner plate in front of his dad like 10 times and didnt wake up for like 20 minutes (embarresing) each time & when he did this with oxycodone he had a simular experience although minus the dph.

I would also imagine the OD potential is greatly increased, so be careful & seriously whatever SWIY do start low
Swim thanks Swiy for their answer. In Swiy's example of using DCH and Hydro, how did the doses differ from what Swiy would normally take for each substance on their own......like how much did Swiy decrease by? Swiy says they took 120mg DHC and 15mg hydro, but how much of each substance did swiy need to take indivdually to get a similar effect. Swim hopes he worded the question correctly.......he just wants to know roughly how much to decrease from his usual dose of each individual substance?

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codeine, combining opiates, dihydrocodeine, diphenhydramine, drugs, hydrocodone, methadone, morphine, opana, opiate, opiate potentiation, opiates, oxycontin, oxymorphone, percocet, potentiating opiates, potentiation, promethazine, united kingdom

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