Re: 4-Meppp & PAL-287
If you're going to start a drug
info thread, and you've seen there is info on wikipedia, you could at least share that info in your post. From wikipedia:
Naphthylisopropylamine (PAL-287) is an experimental drug currently under investigation for the treatment of alcohol and stimulant addiction.
Naphthylisopropylamine acts as a non-neurotoxic releasing agent of serotonin, norepinephrine, and dopamine, with EC50 values of 3.4 nM, 11.1 nM, and 12.6 nM, respectively. It also has affinity for the 5-HT2A, 5-HT2B, and 5-HT2C receptors (EC50 values = 466 nM, 40 nM, and 2.3 nM, respectively), and acts as a full agonist at 5-HT2B and as a partial agonist at 5-HT2C, while its affinity for 5-HT2A is probably too low to be significant.
In animal studies, naphthylisopropylamine was shown to reduce cocaine self-administration, yet produced relatively weak stimulant effects when administered alone, being a lesser stimulant than d-amphetamine for comparison. Further research is now being conducted in primates to see if it will be a useful substitute for treating drug addiction in humans as well.
An important observation is that in behavioral studies, rodents would consistently self-administer selective norepinephrine and dopamine releasing agents such as d-amphetamine, yet compounds that also release serotonin like naphthylisopropylamine would not be self-administered.
Systematic (IUPAC) name
CAS number 18085-03-5
ATC code None
PubChem CID 10219723
Mol. mass 185.27 g/mol
SMILES eMolecules & PubChem
Synonyms 1-(2-naphthyl)-2-aminopropane; alpha-methylnapthylethylamine
Pregnancy cat. ?
Legal status Uncontrolled