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Ethnobotanicals Psychedelic plants, Iboga, Calea, Blue lotus, Ephedra, Sinicuichi, Betel nut, etc.

 
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  #1  
Old 09-09-2010, 03:14
Porvata Porvata is offline
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Cannabinoid activity of Kanna!

This came out earlier this year. Here's the abstract and the article is linked below.

Quote:
Abstract: The whole plant extract of plant Sceletium tortuosum, plant native to South Africa, has been known traditionally to have mood enhancing and stimulant properties. These properties have been confirmed before by proving serotonin-uptake inhibition activity. A further confirmation by using CB1 receptor binding assay has been performed in this study. The unfermented alkaloid extract was proved to posses a higher activity to bind CB1 receptor compared to that of the fermented one. GC-MS analysis confirmed that unfermented alkoloid extract contain more alkaloids than the fermented one. The methanol extract was also more active than the fermented one, suggesting that non-alkaloid compounds in this extract could posses this activity. An additional test to check wether this extract can improve cognitive function and memory was performed by acetylcholinesterase inhibitory assay. Both fermented and unfermented alkaloid extracts could inhibit acetylcholinesterase with IC50 being 0.303 mg/ml and 0.330 mg/ml, respectively. However, the major alkaloid in the extract, mesembrine, did not show inhibition of the enzyme. A TLC based test proved that other alkaloids in the extract were responsible to the activity. Keywords: Sceletium tortuosum, cannabinoid CB1, acetylcholinesterase, alkaloid, kougoed
Isn't fermented kanna typically considered preferable? From what this article suggests it's the other way around!

Full article - http://docs.google.com/viewer?a=v&q=...DtkXvlB78cyIcw

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interesting thread, thought provoking and raises interesting questions
  #2  
Old 09-09-2010, 04:34
Erumelithil Erumelithil is offline
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Re: Cannabinoid activity of Kanna!

SWIM is currently growing some Sceletium Tortuosum plants so this thread is very interesting to him.
SWIM has never tried Kanna before, so naturally SWIM wants to know, "to ferment, or not ferment... that is the question!"

Hopefully some people with more knowledge will post on this.
  #3  
Old 10-09-2010, 01:43
Porvata Porvata is offline
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Re: Cannabinoid activity of Kanna!

Quote:
Originally Posted by Erumelithil View Post
SWIM has never tried Kanna before, so naturally SWIM wants to know, "to ferment, or not ferment... that is the question!"
The GC-MS shows that kougoed, the traditional fermented form of Kanna contains primarily Mesembrine and Mesembrenone whereas the unprocessed plant material contains Mesembrine, Mesembrenone, Mesembrinol, and Mesembrinal. Based on this it seems that fermentation converts the other minor alkaloids, namely Mesembrinol and Mesembrinal into Mesembrenone or Mesembrine. The article mentions the possibility that the substance responsible for the cannabinoid activity which was seen most in unfermented material is possibly a result of a synergistic effect of the combination of the numerous alkaloids. At this point it's unclear if the synergistic effect is responsible or if a still unidentified substance is being broken down by fermentation. What is clear is that for cannabinoid effects unfermented is preferred, whereas empathogenic effects fermented might be ideal. Freshness of plant material is also something I'm curious about, as I'm wondering if they worked with dried material or fresh which could affect alkaloid concentrations.

This find is fascinating, considering the fact that there aren't many known cannabinoids that occur in plants other than Cannabis. There are the N-acylphosphatidylethanolamines found in the oils of Peanut, Safflower, Olive and hempseed, although from what people have found with experimentation more pain-killing (CB2) effects have been noticed. NAPEs are also produced in the body as precursors to endocannabinoids so ingesting them from these oils probably increases levels of anandamide and other related compounds. The only other natural cannabinoids I can think of aside from anandamide in Cacao and the NAPEs are Falcarinol (CB1 antagonist) from Carrots and the alkylamides (CB2 agonists) from Echinacea. If a single compound is responsible for the CB1 activity from Kanna and is not structurally similar to anandamide and other endocannabinoids then that'd be pretty cool.

Post Quality Evaluations:
Very interesting information, great article. Thanks for sharing.

Last edited by Porvata; 10-09-2010 at 07:02.

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cannabinoids, cb1, cb2, drug, drug test, drugs-forum, extraction, kanna, mesembrine, sceletium tortuosum

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