A good dose of LSD with maybe a touch of mushrooms in a well set up room seems to work the best. My lab rats responded best when the mushrooms were added, they said* it helped smooth the whole thing out. Success was highest when strong emotional triggers were brought up durring the course of the experiment. Questions of identity are a good start.
I went through a 'sober' (as in i was stone sober the minute before it occured, no chems at all) ego loss over a year ago trying to define male and female and how they applied to my self. This resulted in a shattering of my already delicate gender identity, an end to wearing pants and all sorts of issues when asking girls out.
Ego loss is a potent tool and a difficult one to wield. The incedent mentioned above took me by total surprise and was far from pleasent. I was forced to face something full on that, at the time, I was investigating slowly, from a distance. There's no turning back. The divided has been united and obliterated in one swift blow, any attempt at recronstruction would be but a flimsy mockery of the original. Course I'm a hella lot happier now, kind of... but this isn't about that.
Alot of the rituals Crowley wrote are a decent start, they aren't easy but I'll refer you to
http://www.sacred-texts.com/oto/lib831.htm Liber Yod Sub Figura DCCCXXXI as a set of practices designed for the specific purpose of oblitering self. These take ALOT of work, discipline, and probably best done on a hermitage. The first method is probably the fastest, but in speed it demands knowldge and techniques not easily availible. The last method is far less destructive as the middle two but will still take alot of discipline; it is probably the easiest to obtain if one isn't well versed in the occult or has issues with sytematically rendering oneself utterly useless to the outside world.
I'm sure the Buddhists have some well developed techniques for this purpose.