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Ethylphenidate is the ethyl ester of 2-phenyl-2-(2-piperidyl)acetic acid, in the similar manner that methylphenidate is the methyl ester
Ethylphenidate has appeared at some UK based research chemical suppliers, touted as a replacement for cocaine. Ethylphenidate reportedly and according to several studies, has higher affinity for the dopamine transporter, but a lot less activity at the nor-epinephrine receptors, apparently this causes more euphoria, with a lot less jittery/side effects than methylphenidate. It is commonly available as the HCl salt, designed for oral or nasal application and as the freebase, which is touted as a replacement for crack cocaine, as it apparently can smoked/vaporised "crack style"
Legal status: Not mentioned in the UK's Misuse of drugs act, and no analogue wording covers esters of Ritalinic acid, as well as this it is being sold by UK based research chemical suppliers In the US: Since methylphenidate is a schedule 2 substance,and ethylphenidate is merely the ethyl ester instead of the methyl, the federal analogue act definitely applies, no ambiguity there, so it is illegal
For racemic ( (S)-ethylphenidate is more active then the (R)-ethylphenidate ) Insufflated
10 - 25mg - Threshold
20 - 50mg -Average
40 - 75mg - Strong
75+mg - Very strong
Smoking (as freebase)
Users report this is very harsh on the lungs and throat
No concrete reports with "safe" doses
Doses for oral are between 50-100% more than snorting
Rectal Similar to snorting, but seems to come on faster, slightly lower doses requiredThreshold/study aid: 5-15mg
Increased music appreciation
Warm fuzzy body high
Increased sociability/desire to talk
Promiscuity/increased sex drive
Chest pain Vasoconstriction
Dick shrinkage/erectile disfunction
Inability to concentrate on one task
Compulsion to redose
Pain (sometimes severe) from snorting, possible nasal damage, nose bleeds
Thats very interresting. Because SWIM has used both Methylphenidate and Dextroamphetamine before and was surprised when SWIM found out Dextroamphetamine wasn't as euphoric. SWIM has also loved the buzz of the Alcohol and ritalin combo and now SWIM wondering about this... Ethylphenidate.
SWIM sampled 100mgs of Ethylphenidate the other day and to be honest felt nothing. No euphoria, no stimulation - nothing! No side effects like dry mouth or gourning - nothing! SWIM may as well have taken a paracetemol. The only thing that SWIM can think of that may have affected this is his trying of Diclofensine the night before but can't see any reason why it would have effected him like this.
However a friend of SWIMs claimed to also have tried ethylphenidate and reported mediocre euphoria but no stimulation. Please bear in mind this is hearsay and don't go out buying ethylphenidate on this basis.
Piglets friend Eyore snorted 3 fat lines & I liked it. A lot smoother than pervatin & it only lasted about 2 hours. He thinks this was racemic product, the D enthryo pure isomer is SUPPOSED to be on it's way & that should be 2.4x stronger. Eyore hasn't tried smoking the freebase but apparently 20mg gives a real crack-like rush.
Last edited by Terrapinzflyer; 10-09-2010 at 18:50.
SWIM used 500mg over 8 hours and the only real effects was euphoria, there was no real stimulation. Would make a great anti-depressent. There was a nice afterglow and SWIM felt really good about himself but he would not buy it again.
Interesting, Mr. Hamster has read in these papers that d-ethylphenidate has about an order of magnitude more affinity for DAT than cocaine. That's a bit of kibble for thought. Some even think it might be a methadone to cocaine, but the hamster thinks it's probably pretty addictive and just as moreish as cocaine.
The hamster has noticed that combining methylphenidate with alcohol is quite euphoric and moreish as the methylphenidate undergoes transesterfication in the liver much the same way cocaine does to produce cocaethylene.
A hamster, chinchilla or gerbil would be best advised to treat this one with caution.
Last edited by Wanderer; 08-07-2011 at 06:22.
Reason: Dorrected l-ethylphenidate to be d-ethylphenidate. Confusion in the papers dl vs +- terminology made for confusion.
haha SWIM just bought some concertas after reading about ethylphenidate yesterday. SWIM hopes it to be about as euphoric as dexamp because he needs to find a less addictive and neurotoxic substance than amphetamines (SWIM was becoming habituated).
Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29482, USA.
Ethylphenidate is formed by metabolic transesterification of methylphenidate and ethanol. Study objectives were to (a) establish that ethylphenidate is formed in C57BL/6 (B6) mice; (b) compare the stimulatory effects of ethylphenidate and methylphenidate enantiomers; (c) determine methylphenidate and ethylphenidate plasma and brain distribution and (d) establish in-vitro effects of methylphenidate and ethylphenidate on monoamine transporter systems. Experimental results were that: (a) coadministration of ethanol with the separate methylphenidate isomers enantioselectively produced l-ethylphenidate; (b) d and dl-forms of methylphenidate and ethylphenidate produced dose-responsive increases in motor activity with stimulation being less for ethylphenidate; (c) plasma and whole-brain concentrations were greater for ethylphenidate than methylphenidate and (d) d and DL-methylphenidate and ethylphenidate exhibited comparably potent low inhibition of the dopamine transporter, whereas ethylphenidate was a less potent norepinephrine transporter inhibitor. These experiments establish the feasibility of the B6 mouse model for examining the interactive effects of ethanol and methylphenidate. As reported for humans, concurrent exposure of B6 mice to methylphenidate and ethanol more readily formed l-ethylphenidate than d-ethylphenidate, and the l-isomers of both methylphenidate and ethylphenidate were biologically inactive. The observed reduced stimulatory effect of d-ethylphenidate relative to d-methylphenidate appears not to be the result of brain dispositional factors, but rather may be related to its reduced inhibition of the norepinephrine transporter, perhaps altering the interaction of dopaminergic and noradrenergic neural systems.
I apologise if I have read this incorrectly (as I am intensely tired) but from what I can see, this research seems to suggest that l-ethylphenidate is biologically inactive, making the d-Isomer the only viable option for research chemical suppliers and users alike.
If this is the case it would certainly explain the abscence of effects reported by some swimmers. I must say that I find it curious that the l isomer was chosen by RC suppliers as opposed to the racemate.
Mr. Hamster has re-read both papers and there was some confusion on his part regarding the terminology between the two papers for identifying the isomers. One paper used the d/l designation and the other uses +/-.
The d(+) isomer is more active by an order of magnitude at dopamine reuptake inhibition than cocaine. It later goes on to state that the increased activity in the + isomer has prompted some manufacturers to formulate isometric versions preferring the d(+) isomer, one of which being Focalin by Novartis.
The hamster agrees that is is odd that the RC developers would be concentrating their efforts on the l-ethylphenidate isomer since it is relatively inactive, according to the above papers.
Hopefully that clears that up, and thanks for pointing out the mistake the hamster made by stating l- instead of d- for the active isomer. He's corrected it in the above post.
It seems very strange to me that L-threo-ethylphenidate is being sold on the rc sites, by reading through many experience reports it seems the L isomer happens to be the distomer, just like with methylphenidate....I'm suprised the L isomer has any effect at all, maybe it undergoes epimerization in the body to some extent to give some of the racemate....better off just going with the D isomer or the racemate to start with IMO....
From what I can understand by the reviews Ethylphenidate sold by RC providers is crap. is there anyone to disagree with this?
Not necessarily, though 2 has this to say:
I have received some amazing crystals labeled as Ethyphenidate from someone in Canada, they were quite active, feeling it from 10mg going all the way up to about 50mg for a really nice euphoria which lasted hours. Lingering stimulation is very nice, not jittery at all. There is no reason for me to believe this is not Ethylphenidate so far, I'll try another sample from a more reputable Canadian source to see if they match up.
"Informal results" are back. A warning, of sorts: Another "more-ish" compound, it seems. Potential for cardiovascular trouble probably (stress, probably) lower than with, say, MDAI, MPA, or Dimethieocaine, and like. Still, impulse to re-dose being what it is.
Alright, so a few other things worth mentioning:
- It seems to be a popular idea to snort this drug. SWIM personally hates this method. It burns, pretty badly (not the worst, but bad) for one thing. Also, at one point, it caked up SWIM's nostril, and presumably his sinuses, as well. He was blowing Ethylphenidate saturated snot out of his right nostril for... God, two, maybe three, days? He'd recommend some other method.
- For recreational use, SWIM tried this drug IV, and it does produce a euphoric rush, fairly similar to cocaine (though lacking some other things familiar, such as numb tongue, and nausea). SWIM would definitely advise caution, though. Like coke, the urge to re-dose is high. The come-down is sharp, and ugly. Also, the drug's overall duration is considerably longer than coke, but the high is only (seemingly) slightly longer. Also, SWIM noticed that his heart-rate and blood pressure didn't seem to spike as much, as with coke. However, he did not take any measurements at the time.
- Just like with coke, high dose, short interval dosing is a profoundly bad idea. SWIM found this out the hard way, though he pretty much knew it was all but guaranteed, and proceeded irregardless (try to avoid copying the behavior, you'll be glad you did). Now, SWIM is very much hesitant to recommend any "drug combinations" knowing how dangerous they generally are, but Ethylphenidate is like coke also in the way that the best way to dose (and stretch out whatever amount you have) is to do one, then leave it be for a few hours (at least). This is (another) hard one to do this with, so having some other drug (that won't interact negatively, or is unlikely to) around might be a decently good idea. I'm reluctant to suggest sedatives, pot, alcohol, opiates, etc. ...However, that's what SWIM knows he would want around to deal with the comedown.
- Finally, SWIM wanted to note that repeated re-use will produce side-effects very similar to binge use with other stimulant type drugs. Nystagmus, ataxia (peripheral), stimulant psychosis, etc. It's a very uncomfortable drug to binge on.
- This drug has potential beyond just recreational use. Like it's more popular sibling, Methylphenidate (Ritalin), I think it has potential to do well in the treatment of refractory depression, where other meds have failed. The catch is that the drug, for this use, is best dosed orally. A glass of juice would work.
"Wish I could say one way or the other. The vendor it was received from did not state whether the products was racemic, or if it was composed of one specific stereoisomer. I suppose it could have been a mix, as well (not 50/50, but maybe some other ratio). None the less, injection never brought about any unforeseen issues, but as always, use great caution."
It should be made clear, the subject/s of this report failed to observe proper safety and weighing procedure.
The observed person (person-A) took a 1/4th of a teaspoon of dl-ethylphenidate and mixed with 50units water... after watching person-A clear the barrel, a tingling in the injection arm was noted. Euphoria didnt seem that potent but observing another reaction (person-B) at a smaller dose; a good level of euphoria was outwardly noticeable.
Four injections were observed from observed from person-A in a 24hr period. Doses escalated from 2x~100mg injections (5hrs apart) to 2x 200mg doses (4hrs apart). Person-A commented the first set of 200mg injections had the best effect. Person-B also commented that when their dose was double, the effects were noticeably more euphoric and enjoyable.
The ferrets tried 100 mg ethylphenidate IV followed by another an hour later. No rush and the same effect as oral only faster onset. The ferrets do not think it is worth IVing anything unless there is a rush and this does not have one. Overall ethylphenidate is mostly a functional stimulant and is minimally recreational for the test ferrets unless very high oral doses are taken (ie 300+mg). The nice thing about it is that it does wear off fast allowing user to sleep 6 hours after the last dose. Note the ferrets experimented with all other routes of ingestion first and had a good handle on this stuff's effects. Never IV anything and if you do, get to know the chemical really well first.
Interesting information on the conjoining of those substances. SWIM has taken both together, and to be honest, SWIM always received a nausous, unsettling feeling in the abdominal region. If SWIM is reading this correctly though, Ethylphenidate is a substance resulting from the two being chemically combined via a laboratory, not the ingestion of the two precursors separately, having them mix after ingestion.
SWIM would definitely try this version, likely assuming the previous negative side effects were caused by the gastrointestinal system being the location of the chemical change, among other things.
Got some crystal ethylphenidate today and it's really nice, like a more scatty version of cocaine with less stimulation. I will write up a proper report in a bit. Dosage seems to be good at 50mg lines. Lasts for quite a long time am still wired from 2 lines, last one I did was around 2 1/2 hours ago.
1.5-3hours comes on almost as quickly as cocaine does (around 5mins after snorting)
Abstract thinking Euphoria
Some stimulation but not like with cocaine or ritalin
Increased music appreciation
Warm fuzzy body high
Inability to concentrate on one task
Legal in the UK
It's very different to ritalin. When I did ritalin at uni it allowed me to focus on one task such as revising or writing an essay. I don't think I could work for shit on this stuff. My mind was all over the place, thoughts constantly skipping from one thing to another yet at the same time finding it impossible to multi task. Burns a bit going up but soon stops. Would liken it to cocaine without the same level of stimulation but with a whole lot more gurning.
Its odd so many people have gotten so many different reactions to racemic-ethlyphenidate, most people Ive observed using this chemical seem to function well @ higher doses, I observed some1 doing their gardening for 4hrs straight after a big dose; they were cutting the edges of their lawn with a sharp knife.
Quite a few subjects said they preferred the high of ethylphenidate over (m)amphetamines and then a lot people said they prefer good speed over it... imo, disregarding the mild stimulation (which seem to vary for between people), the euphoria quality of 100-200mg is quite competitive for the price.
I got a free sample of this chemical from my regular mxe supplier, and I'm planning on shooting it. However, yesterday I read something about how acidic EPH is and that's why it burns so much when sniffed. Is it true? Would it be dangerous to I.V it? Won't it kick my ph out of balance if I shoot it?
Wheb snorted it burns for maybe 15-20 seconds then sort of numbs itself the burn isn't all that bad though only a bit worse than ketanine. Have heard you can iV it no probs though but you would need to find some first hand reports. I am going to try freebasing it today will report back