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  #1  
Old 18-11-2005, 14:26
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<h1>Tylenol / Acetaminophen</h1>



Tylenol is the most popular painkiller in the United States as
Americans consume over 8 billion Tylenol pills each year. Tylenol or
acetaminophen is typically used as a pain-reliever (analgesic) and
fever-reducer (anti-pyretic). Acetaminophen can also be found in many
over-the-counter and prescription medications such as Nyquil,
Robitussin, Benadryl, Alka-Seltzer, Vicodin, Percocet, Darvocet, and
more.




Medical professionals have identified that large doses or long-term use
of acetaminophens can cause liver damage which may lead to liver
failure and death. Acetaminophen overdose is the leading cause of liver
failure in the U.S. and the United Kingdom. The severity of this
problem has lead to several studies and an educational campaign
launched by the FDA.




The American Liver Foundation states that Acetaminophen is normally a
safe drug but turns into a hepatotoxin when dosed incorrectly or under
certain conditions. Unfortunately, many people do not take the
recommended doses or unknowingly take Tylenol in combination with other
medications or with alcohol. The recommended daily dosage for adults is
4000 mg but this dosage should be cut in half when using extra-strength
Tylenol, when consuming alcohol, or when using other drugs containing
acetaminophen. Parents administering Children’s Tylenol need to be
especially cautious as recommended child dosages can range from 80-160
mg.




Consumers with a decreased liver function, kidney disease,
hepatitis, malnutrition, AIDS, chronic ethanol abuse, or anorexia
nervosa may be at increased risk for liver failure and death when using
Tylenol. For diabetics, acetaminophen may also affect the results of
blood glucose (sugar) tests. Some acetaminophen drugs may contain
aspartame, sulfites or caffeine. While Tylenol has been on the market
for 50 years, many professionals feel that the proper dosage of
acetaminophen for children and adults is still unknown and more testing
and education is necessary to prevent liver damage and accidental
deaths.




Acetaminophen is the active ingredient in a variety of
over-the-counter drugs, most notably Tylenol. Acetaminophen overdose is
the leading cause of calls to the Poison Control Centers across the
United States. It is estimated that acetaminophen poisoning calls
exceed 100,000 per year. Studies indicate that acetaminophen overdose
results in over 56,000 injuries, 2,500 hospitalizations, and an
estimated 450 deaths per year.




The most significant risk involving acetaminophen is acute liver
toxicity. Data acquired from the U.S. Acute Liver Failure Study Group
registry indicates that nearly 50% of all acute liver failure in this
country is linked to acetaminophen poisoning. There have even been
reported cases of acute liver toxicity in individuals whose
acetaminophen dosage did not exceed 4 grams/day. Surprisingly, a dosage
of 4 grams/day falls within the recommended dosage for Extra Strength
Tylenol.




Acetaminophen based drugs have been the cause of acute liver failure in
hospitals around the country. While the drug can be safe in small
doses, it can potentially be fatal for those who consume alcohol, take
the drug in high doses, or simply use it regularly.



https://www.lawyersandsettlements.com/case/tylenol


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  #2  
Old 18-11-2005, 22:32
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For those based in the UK: Acetaminophen is Paracetamol, which is often available in combination with codeine (Kapeke, co-codamol etc). SWIM has seen compound preparations used for recreational purposes, and has seen accidental od on paracetamol as a result.


In certain parts of the world (possibly Australia?)paracetamol is only sold in compound preparations with it's antidote (acetylcysteine). This has no effect on pain relieving effects, but prevents the liver damage (which is caused by toxic metabolites which deplete an enzyme called glutathione).


Be Safe


Edited by: jatelka
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Old 09-12-2005, 08:20
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4000mg seems to be a high daily dose to me
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Old 09-12-2005, 08:24
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Quote:
Originally Posted by DoorsPerception
4000mg seems to be a high daily dose to me
Ill say, ill never take anymore than 1500 mg of this stuff in about a 3 day span, and when SWIM uses pills for recreation CWE is always a must. Use the cold water extraction people it could save your liver and possibly your life.
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  #6  
Old 10-12-2005, 23:03
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Ummmmmmmmm nothing, was that a real question? It's just held in the pills such as hydrocodine, darvocet, perkocet. To many pills in one day = BLAH!

Muirner
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Old 10-12-2005, 23:11
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Ya, like Muirner said, its found in many pharmaceutical opioids/opiates. This is most likely what makes it the leading cause of liver failure, too many neive people popping pills like mad to get messed up not even caring that their loaded with tylenol (or simply not knowing that its so bad for your liver).
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