Drug info - (R)-(-)-dragonFLY

[joachimist]

(R)-(-)-1-(8-bromobenzo[1,2-b-4,5-b~] difuran-4-yl-2-amino propane
any info about it ?

seems to be not dragonfly but little different
what does the (R)-(-)- mean?
what dose should swim start ? (he was planning 100ug)

[Iggypoop]

I don't do iupac names but does that mean that is only one isomer?



Really i dont know, just a guess.

[snapper]

R refers to one of two isomers, the other being S. I think that this
notation refers to enatomeric isomers, which is like your right and left
hand. Both have the same number of fingers, but they cannot be
substituted for each others since their configurations are a mirror image
with the fingers in the exact opposite order.

Sorry for the disjointed explanation - maybe some of the real chemists on
this board can explain it better. I'm guessing the R isomer is more active ?

Snapper

[joachimist]

that could explain why peoples reported differences in drgonfly
experiences, some tripping from 100micrograms and others noticing only
very little up to 1,5mg. (from different supliers or different batches, the
proportion of R/S differ)
Maybe the S is inactive or so.

swim's plannig to do it sublingual first, starting at 50um `
after 2hours if nothing yet he'll redose 50um sublingual every hour untill
something is noticed.

he also have some 2C-B-fly not tested yet. don't know wich one to start
with.

[Iggypoop]

Thanks for clearing that up, glad someone knows what they are talking about.

[snapper]

2CB FLY is a shorter ride. You are probably correct that each isomer is
likely to be different, since even though the # of atoms is the same, the
structure is functionally different. The question is, does anyone know
which enantomer is more active?

Snapper

[joachimist]

i don't know how to explain it, but i believe the R isomer is more active in brain

[nanobrain]

^these chemicals are not manufactured for their activity but rather for research purposes - as confirmed by many compounds available with no / adverse biological activity in the higher primate model.

now, i'm agonna start craking down heavily on any furhter references of iupac in re marketing, get my drift?Edited by: nanobrain

[joachimist]

Enantiospecific synthesis and pharmacological evaluation of a
series of
super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists.

Chambers JJ, Kurrasch-Orbaugh DM, Parker MA, Nichols DE.

Department of Medicinal Chemistry and Molecular Pharmacology, School
of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette,
Indiana 47907, USA.

The affinity of ligands for either the 5-HT(2A) or 5-HT(2C) agonist
binding site was enhanced by modification of the 2,5-oxygen
substituents that are found in typical hallucinogenic amphetamines such
as 4b (DOB). Restriction of the conformationally flexible 2,5-dimethoxy
substituents into fused dihydrofuran rings generally resulted in increased
potency relative to the parent 2,5-dimethoxy compounds. The pure
enantiomers of these arylalkylamines were obtained by enantiospecific
synthesis that involved acylation of the heterocyclic nucleus 7 with N-
trifluoroacetyl-protected D- or L-alanyl chloride, followed by ketone
reduction and N-deprotection. The enantiomers demonstrated modest
stereoselectivity at the two receptors. Several general trends within these
classes of new compounds were observed during their pharmacological
investigation. For most pairs of optical isomers tested, the R-enantiomers
of the compounds containing heterocycle 7 bound with only slightly
higher affinity than their S-antipodes at the 5-HT(2A) and 5-HT(2C)
receptors. Likewise, functional studies indicated that the R-enantiomers
generally displayed increased potency compared to the S-enantiomers.
Aromatization of the dihydrofuran rings of these arylalkylamines further
increased affinity and potency. Only a few compounds were full agonists
with most of them possessing intrinsic activities in the range of 60-80%.
These compounds with a fully aromatic linear tricyclic nucleus are some
of the highest-affinity ligands for the 5-HT(2A) receptor reported to date.



Bromo-DragonFLY IUPAC nomenclature, Chemical nameBromo-
benzodifuranyl-isopropylamine or(1-(8-bromobenzo[1,2-''b'';4,5-
b']difuran-4-yl)-2-aminopropane Chemical formulaC13H12BrNO2
Molecular mass294.15 g/mol Melting pointdecomposes at 240 °C
(hydrochloride) CAS registry number, CAS number- Simplified molecular
input line entry specification,
SMILESN[C@H](C)CC1=C(OC=C2)C2=C(Br)C3=C1C=CO3 (''R''-isomer)
Image:R-Bromo-DragonFLY.png, chemical structure of (''R'')-Bromo-
DragonFLY Bromo-DragonFLY is a psychedelic hallucinogenic drug of the
phenethylamine family. Bromo-DragonFLY is a the most potent known
hallucinogen, it is even more potent than LSD but it has an an extremely
long duration of action. Bromo-DragonFLY has a stereocenter and ''R''-
(-)-bromo-DragonFLY is the more active stereoisomer. Pharmacology The
hallucinogenic effect of bromo-DragonFLY is mediated by its partial
agonistic activity at the 5-HT2A 5-HT receptor, serotonin receptor, but
bromo-DragonFLY also has a high binding affinity for the 5-HT2B and 5-
HT2C serotonin Receptor (biochemistry), receptor. History Bromo-
DragonFLY was first synthesized by Matthew A. Parker in the laboratory of
David E. Nichols in 1998. See also * 2,5-dimethoxy-4-
bromoamphetamine, DOB * PiHKAL External links References * 'A novel
(benzodifuranyl)aminoalkane with extremely potent activity at the 5-
HT2A receptor' by M. A. Parker, D. Marona-Lewicka, V. L. Lucaites, D. L.
Nelson, and D. E. Nichols in ''J. Med. Chem.'' 41(26): 5148-5149 (1998)
[http://dx.doi.org/10.1021/jm9803525 DOI: 10.1021/jm9803525] *
'Enantiospecific synthesis and pharmacological evaluation of a series of
super-potent, conformationally restricted 5-HT2A/2C receptor agonists'
by J. J. Chambers, D. M. Kurrasch-Orbaugh, M. A. Parker, and D. E.
Nichols in ''J. Med. Chem.'' 44(6): 1003-1010 (2001) [http://dx.doi.org/
10.1021/jm000491y DOI: 10.1021/jm000491y] Categorization
{{Hallucinogenic phenethylamines}} ...</font>


Bromo-DragonFLY has a stereocenter and ''R''-(-)-bromo-DragonFLY is
the more active stereoisomer.

[JewishNazi]

With MDMA being maybe the only exception, the R isomer of PEAs in stronger


DOB-DFly is meant to be like DOB in its com-up (about 2 - 3 hours). If you keep dosing every hour, you might dose an extra 50 or 100ugthat isnt needed


Also, it is beleived by some that an IM injection is the only way to get any sort of result from doses in the mincrogram rangeEdited by: JewishNazi

[joachimist]

here is what swim told me

Originally Posted by swim

wow
i cant do a trip report by now because it's not finish yet but its powerfull
for sure
i did 100ug maybe 4h ago and its snowing i just don't now if the snow
copme from me eye or if its real anyway its amazyng multip color snow
there is no more sky just snow i've to go back with friends i just wanted
to tell you my first live feels but difficult to express i need to move into
the snow


oh i forgot to tell i took it under lingual after brush and cut with small
glass pieces

i come ll back after effects gone

[joachimist]

swim just told me this

Originally Posted by swim

im so happy to be a lab rat lost in white snow

[Iggypoop]

You cut your mouth open to get better absorbtion?



Thanks pretty mad, IMing would probably be less painful...

[Nagognog2]

I am thinking of the song: "Friggin' in the Riggin'" by the Sex Pistols right about now...ZOUNDS! That's what I call a Lab Rat!

[enquirewithin]

Originally Posted by _jo_

oh i forgot to tell i took it under lingual after brush and cut with small

glass pieces

Sounds like the kind of thing Iggy Pop would do!

[joachimist]

swim answer :

Originally Posted by swim

i didn't really cut my mouth i just "brushed" parts with very very small
powder of glass
it doesn't really hurt (well it does but not that much) and it makes the
absorption much better

maybe it isn't needed but i believe it helps

maybe IM or IV is better but i have never done it and it scares me a little

i'm writting a complete trip report for this product but its in french so i'll
translate maybe tomorow

it was one of the best trip of my life, especially at the end when i took
some salvia extract it gave something very nice and very especial.
(salvia + tryptamines has also always be very good for me i really like the
"chamanic" side of this mix and both products really symbiose)

i'll tell you more next time (no time)

[snapper]

Where is your french trip report ?
I can read that language..

Snapper

[Nagognog2]

I, for one, am looking forward to reading this. Information on DOB-Dragongfly is sorely lacking. Please include as much information as possible such as: How long it has been since your lab rat had taken any other psychedelic (establish possible tolerance), last time food had been consumed (empty stomach even though taken sublingual), etc.


Most reports I've found were written by people who got it from unreliable sources. And had no real clue regading what it is.This report will go into my archives - The Fly-Papers.

[Toltec]

well it's not active orally; as shulgin says, it has to be injected.
Got this info form what he said during the O&A.

[Benga]

Originally Posted by _jo_

i didn't really cut my mouth i just "brushed" parts with very very small
powder of glass
it doesn't really hurt (well it does but not that much) and it makes the
absorption much better

maybe it isn't needed but i believe it helps

wait I'd never heard of anyone doing this before, and I'm very interested in increasing buccal absorbtion possibilities.
Mind if I stear off the thread's subject for a minute and ask you to expand on how you do this ! How do you prepare the powdered glass and and use the brush ?

trip report in french is fine here as well.

thanks
b

[RaverHippie]

I'm sad that the user hasn't been around for more than 6 months and left us hanging...anyone hear of the trip report? I noticed his post in the big bromo-dragonfly thread saying he had lost it, maybe it was scrounged up somewhere?

[tokingchicken]

So if some of you saw the thread i created on bromo dragonfly id like to add some things here. Swim ate 2 hours before taking the two unknown chemical blotter. (thought to be bromo now) Swim was already feeling really spacey, confused, and body highish at one hour. By 3 hours swim was totally up, so with that logic how large of a dose could anyone guess that is?

[RaverHippie]

No one knows. That dose response curve matches up with a long list chemicals and since it was on a blotter no one can be certain.