Tropacocaine is similar to cocaine
in that it's a benzoic acid ester, as opposed to an ester of tropic acid like atropine
and scopolamine. It's is also similar to atropine and scopolamine in that it has no carboxylic group attached to its tropane skeleton, unlike cocaine. Based on the structure, I would expect it to be considerably less effective than cocaine as an inhibitor of DAT (dopamine
transporter protein). It's reportedly more than 1000 times less potent than scopolamine as an anticholinergic. Apparently (according to jeronimo's post) it has local anaesthetic acitivity, which may possibly explain its toxicity (LD50
) at 15-20 mg/kg i.v. in rats - comparable to cocaine at approximately 17 mg/kg.