7-hydroxy-mitragynine

[dogen]

anyone heard of or know of anyone who has tried this?

swim may have access to it soon, and he has asked me to do some research for him as he doesn't have access to a computer.

[nanobrain]

you have the spelling wrong, its mitragynine.

is this some sort of kratom isolate?

[sands of time]

7-hydroxy-mitragynine is a strong drug found in kratom. It is stronger than morphine, but it is found in very small amounts in kratom. Mitagynine is found in much higher amounts in the plant.

[dogen]

hmmm...i spelled it exactly as you did


he would like to know the recommended dose ranges, effects, etc...


he's assuming that it's quite like kratom, which he's never tried, only heard about.


any info would be much obliged.

[allyourbase]

heheheh I know ofsomeone who probably has a supply of that....

[glogga]

According to some recent research it now appears that 7-hydroxy-mitragynine may be the main active component in kratom. Its there in much lower quantity than mitragynine but it is much more potent.

[mushroom-man]

Has anyone tasted this yet? Apparently it is reported as
being very difficult to synth from Mitragynine, and difficult to isolate from
it in the natural product. It may be coming a near a rat soon.
But she was wondering just how hard it should be to synth? Also, has anyone
worked on an acid/base extraction procedure for these Kratom alkaloids?

She heard a rumor that it is very worthy of indepth research. Unfortunatly, initial $$ is a bit on the high side...

Peace,

Mush

[Nagognog2]

Want research to continue? Then stop posting here on open and drawing a bullseye on your ass, okay?

[nanobrain]

Boom Shaka Raas Klot!

[Alfa]

Originally Posted by zenben

7-hydroxy mitra.
1-3mg-very light "opiate-like" effects, hardly noticable.
4-5mg-a little more like a low dose of pain killers (10mg vicodin) but nothing like morphine or even OC. The experience was followed by a feeling of sleepiness and slight depression that SWIM associated with the after effects of opiates.
Conclusion: SWIM things 7-HO Mitra. is overrated and TOO EXPENSIVE! The 5mg dose was about $25 and effects were comparable to $5 worth of perscription pk.

There must have been more people tasting this material in the meantime. Please post experiences here.
What was the dose, duration, after effects?

[Alfa]

Here are some collected experiences and posts:

Originally Posted by Zenben

I just wanted to give my 2 cents on the tinctures. I have tried 90% mytragynine, 7-hydroxy Mitragynine, and 7-Acetoxy Mitragynine and I found only the 7-Acetoxy M. and 7-OHM. remotely interesting, yet something was definately missing from the experience. This was about 6 months ago and my doses may have been a little on the low side, mostly because the price is so high, but IMHO, I prefer powdered extracts.

Originally Posted by Jacky

I think that kratoms effects are slightly debilatating, causing some dizziness in me if the dose goes much over 10 grams of commercial leaf.

dont get me wrong, I really like kratom, and appreciate the current market very much, but I dont think kratom is in the same league with morphine or opium products. I have used kratom for extended periods of time and avoided the classic opiates and opium products, and was basically content with the material, but there was a flatness to the experience at times, whereas when I am maintaned on morphine or opium containing products the euphoria comes easier.

I havnt tried the purified 7 hydroxy mitragynine, but I have tried the mitragynine 90% and the 7 acetoxy analog, and the 41% alkaloidal resin, with the 41% being particularly a good deal in my opinion.
the mitragynine 90% seems to be more of the sedative side of kratom.
the 7 acetoxy seemed to cause some minor stomach discomfort and stimulation.....
my guess is that the 7-hydroxy is the stimulating, euphoric edge to kratom.

one intrepid explorer reported to me a year ago that they IVd an alkaloidal blend of kratom that they extracted via the standard ph manipulation extractions...the material was suspected around 50% alkaloidal that he ended up with....the portion that was IVd should have been enough to contain 1.5 milligrams of 7 hydroxy....anyway they reported no rush, with a strong effect coming on for a few hours, and a very dizzy side effect. the corresponding amount of leaf that the amount of alkaloidal extract was taken from would have been much more potent than the effect that they gleaned from the alkaloidal material alone. so perhaps there is a synergetic effect of all the kratom alkaloids, perhaps all of them dont make it through extraction, and perhaps the antagonist alkaloid in kratom could actually potentiate some of the effects of the mitragynine alkaloids?

Originally Posted by Uncle BenBen

The Substance and its Source: While talking to a highly reputable entheogen supplier and acquaintance of mine about recent extractions of kava kava and future hopes of performing extractions on kratom leaf, he produced a bottle of an isolated kratom alkaloid, 20mg 7-Hydroxy-Mitragynine, dissolved in 10ml of ethanol. From what I understand, very little is known about the effects of the isolated alkaloids of kratom, and the extraction of 7OHM from kratom requires some fairly advanced lab procedures such as column chromatography. I purchased the bottle for $25CND and proceeded home.

As there is so little information to be found about 7OHM and no previous experiences on Erowid, I’ll include my limited knowledge of the substance.

7-Hydroxy-Mitragynine is a potent partial opioid agonist (could be a full agonist but I believe I read something about it acting on the mu-opioid receptors specifically). Though content by weight in kratom is quite low compared to other alkaloids, it is currently believed to be one of the most active. Lab tests on rats resulted in strong opiate agonistic effects, and seem to have a stronger analgesic effect, in terms of dosage weight, than morphine (This fact causes some confusion for prospective users, and just because it is more active by weight does not mean it feels better or will get you higher). Unlike morphine, 7OHM is very orally active. 7OHM cannot be made into a hydrochloride salt, anything sold as 7OHM in solid form is likely something else. The source of this substance seems to play a major role in its quality, as suggested doses seem quite high (possibly even dangerous) in retrospect and the few reports I’ve read about 7OHM attained from online vendors, appear exceedingly mild.

Subjects:
3 college students all experienced in a wide variety of psychoactive substances
Myself- male, 125lbs, 5’11” substances of choice – opiates
L- female, 150lbs, 5’4” substances of choice – amphetamines, psychedelics
M- male, 135lbs, 5’5” substances of choice – cocaine, alcohol

Experiments:
Took the 7OHM two different times.
The first time, we began by looking up as much possible information on dosage as possible. We found almost none, except one suggesting a dosage range of 5-15mg, which in retrospect sounds excessive. We had no real accurate way of measuring the dosage except for the dropper on the lid of the bottle, so we decided to start at about ¾ of what the dropper was able to pull into it. The first dose, even though considerably smaller than 5mg, produced immediate effects. Over the course about 5 hours we took approximately 4mg (or 2ml each) of 7OHM each by squirting the dropper into our mouth and attempting to hold the rather hot (from the alcohol) and pharmaceutical tasting liquid for as long as possible before swallowing. We all felt quite relaxed and spent most of the time indoors, except for a short walk M and I took.

Taken in this manner the substance produced definite and noticeable effects. Almost a minute after taking the 7OHM I began to feel as if I were coming up on Hydrocodone, but it was a much cleaner, more lucid kind of high. At less than a dropper-full, there was a warming rushing calming kind of sensation, which peaked after about 30 minutes or so. Smoking a bowl seemed to prolong the effects. As we continued to take small doses like these over the course of the night however, a longer term of sedation occurred, and at about 2 ½ dropper-fulls, M felt sick but the feeling subsided after a few minutes. Also, I noticed 7OHM is by far the best aphrodisiac I’ve ever had. When I came on this drug it felt like I was taking nitrous oxide almost. I had the feeling afterward that I had experienced something much closer to a female climax than is usually possible for myself, and have wondered for some time since what men are really missing out on when it comes to pleasure.

The second time, after a day off, just L and I took the 7OHM. Feeling comfortable with the effects of the drug, we decided to experiment with what more concentrated dosing could yield. Knowing that the come up on 7OHM can be somewhat intense, we thought it best not to dose up to the desired level all at once, but to space it out over the course of 1 ½ to 2 hours, taking 1 dropper full every half hour at first, and then with slightly less time in between as we became sure we could handle the dose. With this method we ingested the last 2/5 of the bottle.

While I think it may not be for everyone, for L and I this seemed like the best way to go. This method of ingestion produced a long pleasurable (euphoric, but not to the level of full opiate agonists) come up, followed by strong physical sedation and analgesia, but with a much more lucid mental state. With this method of dosage, during the sedated period of the high L and I were still euphoric and talking was enjoyable.

Effects Summary:
All 3 subjects reported that ingestion of small doses of 7OHM, even a dose of less than a half a milliliter of the solution, results in an enjoyable “rush”, similar to coming up on a stronger opiate, which lasts about half an hour and subsides in a relatively short period of time to a subtle but definitely noticeable calming effect. Though the majority of noticeable effects fade rapidly, further dosing, even after euphoric effects have dissipated, results in another less noticeable rush followed by longer lasting analgesia and mood elevation.

L and I noticed administration of consecutive small doses of 7OHM, far enough apart to avoid nausea, with a cumulative dose of approximately 4mg over 1 ½ hours, results in a much more pronounced euphoric rush, which continues through the dosing phase and doesn’t begin to dissipate until an hour or two after the last dose. This higher dose produced definite euphoria, as well as extreme analgesic effects. Movement became difficult and L could barely balance herself, yet our minds seemed to remain clear and lucid. Mild respiratory depression was present, as well as cardiac stimulation (to a degree uncharacteristic of other opiates). While I can’t say that there was a definite hallucinogenic effect, L and I both seemed to experience some unusual visual distortions and enhancements in color, however this could be exaggerated due to a resurgence of previous hallucinogenic experiences triggered by more mild-moderate visual effects of 7OHM, as L and I both experience some level of persisting hallucination. Despite all these effects L and I had surprising mental clarity and cognitive ability for such a high level of physical sedation/analgesia.

The first time taking 7OHM, there were no noticeable effects the next day except for maybe some apathy and a strong desire to stretch.

The second time there were slight effects the next day, the worst of which being lethargy and some general agitation.

Conclusion:
From the effects I experienced, my hypothesis would be that 7OHM acts strongly on mu (respiratory depression, euphoria, possible but not unavoidable nausea, analgesia) and sigma (cardiac stimulation, hallucination) opioid receptors.

7OHM is a very pleasant, relaxing alkaloid I wouldn’t mind using in the future. It does not seem to be as physically draining or addictive as opiates can be, and though my experiences with 7OHM were quite good I feel no real need or strong desire to take it again in the near future. Of our 3 subjects, M was the only one who got sick, and the feeling subsided after a short period of time. I believe though that there is a danger of overdose similar to that of any opiate, and as sensitivity to 7OHM seems to vary drastically, people just starting out with it should treat carefully.

Far beyond the recreational uses of this drug I believe are its pharmaceutical applications. For the past few weeks I’ve been coping with nerve pain in my left elbow. On the first night I took 7OHM, the pain was rather severe. After taking just the first dose, the pain was notably reduced. After another dose the pain was gone completely, even after the euphoric come up subsided. When taking the doses more rapidly the analgesic effects were some of the strongest I have ever experienced, I felt completely disconnected from my sense of touch. On this dose, the never-ending funny-bone sensation in my elbow and entire left arm, for the first time since the injury, almost was funny. The sensation turned from pain into sort of a warm tingling. While on opiates I’ve always felt pain was still present but I was more placid about it, on 7OHM pain was simply nonexistent. I really feel the medical industry should look into this alkaloid more, as well as individuals with severe pain looking for a less addictive more effective alternative to pharms like oxycodone and morphine.

Originally Posted by raybeez

- With oral dosing, peak effects from 7-OH-Mitragynine were reached as early as 15 minutes after dosing, but had declined in effectiveness by 50% by around the 90min mark. Morphine on the other hand took 60min to reach peak effects, and was still going strong at the 2 hour time point.

- With S.c. dosing, 7-OH-Mitragynine peaked at around the 15 min mark, declining to around 65% of peak by 60min. Morphine administered S.c. peaked just before t=60min, but dropped off its peak within 15min (much more rapidly than 7-OH-mitragynine).

[Alfa]

Involvement of μ-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa

Auteur(s) / Author(s)
MATSUMOTO Kenjiro (1) ; HATORI Yoshio (2) ; MURAYAMA Toshihiko (2) ; TASHIMA Kimihito (1) ; WONGSERIPIPATANA Sumphan (3) ; MISAWA Kaori (4) ; KITAJIMA Mariko (4) ; TAKAYAMA Hiromitsu (4) ; HORIE Syunji (1) ;

Résumé / Abstract
7-Hydroxymitragynine, a constituent of the Thai herbal medicine Mitragyna speciosa, has been found to have a potent opioid antinociceptive effect. In the present study, we investigated the mechanism of antinociception and the inhibitory effect on gastrointestinal transit of 7-hydroxymitragynine, and compared its effects with those of morphine.

When administered subcutaneously to mice, 7-hydroxymitragynine produced antinociceptive effects about 5.7 and 4.4 times more potent than those of morphine in the tail-flick (ED[50]=0.80 mg/kg) and hot-plate (ED[50]=0.93 mg/kg) tests, respectively. The antinociceptive effect of 7-hydroxymitragynine was significantly blocked by the μ[1]/μ[2]-opioid receptor antagonist β-funaltrexamine hydrochloride (β-FNA) and the μ[1]-opioid receptor-selective antagonist naloxonazine in both tests. Thus, 7hydroxymitragynine acts predominantly on μ-opioid receptors, especially on μ[1]-opioid receptors. Isolated tissue studies further supported its specificity for the μ-opioid receptors. Further, 7-hydroxymintragynine dose-dependently (ED[50]=1.19 mg/kg, s.c.) and significantly inhibited gastrointestinal transit in mice, as morphine does. The inhibitory effect was significantly antagonized by p-FNA pretreatment, but slightly antagonized by naloxonazine. The ED[50] value of 7-hydroxymitragynine on gastrointestinal transit was larger than its antinociceptive ED[50] value. On the other hand, morphine significantly inhibits gastrointestinal transit at a much smaller dose than its antinociceptive dose. These results suggest that μ-opioid receptor mechanisms mediate the antinociceptive effect and inhibition of gastrointestinal transit. This compound induced more potent antinociceptive effects and was less constipating than morphine.

Revue / Journal Title
European journal of pharmacology (Eur. j. pharmacol.) ISSN 0014-2999 CODEN EJPHAZ
Source / Source
2006, vol. 549, no1-3, pp. 63-70 [8 page(s) (article)] (36 ref.)

Editeur / Publisher
Elsevier, Amsterdam, PAYS-BAS (1967) (Revue)

Also see: 7-Acetoxy mitragynine

[snapper]

SWIM likes the 7HO / mitragynine mix. SWIM usually does about 1mg worth of the former with about 5mg of the latter the way the tincture is made. This is dried on glass, scraped and insufflated. SWIM feels it works well this way. 7HO can also be vaporized, though mitragynine cannot be. Since most isolates contain both, this might be wasteful. SWIM also usually likes to take these isolates on top of an oral dose of leaf, but has tried without and the effect is a little different.
SWIM does not get the hallucinations or stimulation from 7HO, but more of a narcotic / tranced-out state which in many ways is similar to standard opiates, but has its own edge.. SWIM likes this product the best of those available.

[bigfish1980]

swim has a bottle and would like to try it. can swiy tell me if their 7OHM was yellow in color? this would lead swim to believe that the product is tainted but maybe not. please respond if swiy 7OHM was also yellow in color. Thanks

[snapper]

yes, it's yellow.

[bigfish1980]

Thanks, swim appreciates the info!

[bigfish1980]

Swim tried this yesterday and I have to say that there is definately in opiate receptor binding, but the feeling was not euphoric at all. SWIM just felt very hot and numb with a stoned kinda feeling associated with really poor quality weed. Can SWIY give someone any advice???

[Handle]

SWIM feels this is an appropriate place to ask this question. Who's heard the suggestion that crystalline forms of mitragynine are not possible, does this simply come from the old 'kratom acetate' scam that french guy pulled a few years ago, or is it true? Someone in this forum just said that 7-OH mitragynine can be smoked, but plain mitragynine can't.
Is this related to the claim that fairly pure mitragynine can only be obtained is in liquid form, and crystals purporting to be it are probably false. Also, SWIM has never ever seen photos of any crystals in this whole area [kratom] and all the extracts/lyophilised/purified, they are all BLACK or BROWN and seem impure. SWIM only asks because he's curious, has anyone ever injected kratom alkaloids?
SWIM admits total ignorance.

[radiometer]

Was 7-AcO-mitragynine a scam? This is the first I've heard about that! My buddy Special Eddie once bought, from a very reputable source doing their own lab work, a tincture containing a certain number of mg mitragynine and 7-HO-mitragynine. If I remember correctly, the source had a picture of the crystals in their catalog, and they were tan/brown. It seemed to give basically kratom-like results orally, and the remainder was dried to a brown powder which has never been sampled but sits in a little glass vial for some rainy day. I wonder about the stability of these compounds?

[snapper]

The pure freebase is simply brown/red in color and not crystalline.
Mitragynine burns before it vaporizes, but 7HO does not. Subjective trials confirm only the latter seems to have an effect.
SWIM feels very little research has been done on these products, so definitive answers to these questions are not out there yet. Brave researchers out there need to have test monkeys explore this, of course with the usual disclaimer that vaporizing anything is dangerous, particularly some isolate bought from some random source online.
SWIM has insufflated both and they seem to work best via that route. However, they are not full spectrum like the whole plant and that is why effects may be different and less recreational. SWIM finds a little of the alkaloid on top of an oral dose of leaf really kicks the former in.
SWIM thinks due to the insolubility of these products that injection would be risky.
The 7ACO works, but SWIM does not like the effects.
These compounds seem very stable. SWIM has some dry mitragynine from when it was first offered by a vendor fitting the above profile that is still good. Maybe 1.5 years old now and recently sampled.

Reputation Comments on this post:

thank you kindly, sir!

[j2lo0se]

I read an article of a scientific experiment with kratom and all that and they claimed that 7-hydroxy-mitragynine was in the range of 60 times more powerful than morphine. They also stated that it was not able to successfuly be isolated with no impurities so I'm unsure of how they got that number. Unless anyone here has a Phd in chemistry I highly doubt your extracting anything from this plant, and if you do have a Phd your not on this forum. After everything I've read, 7-hydroxy-mitragynine extraction seems to be just as complex as trying to produce LSD. Not even worth the time If you figured out how to do it, cause it's obviously extremely difficult so just grow some poppies and if you get addicted just grow some more.

Reputation Comments on this post:

actually, i think you will find the core of this forum is rather highly educated...

[enquirewithin]

Originally Posted by j2lo0se

.... Not even worth the time If you figured out how to do it, cause it's obviously extremely difficult so just grow some poppies and if you get addicted just grow some more.

SWIj2o0se can grow poppies and get addicted! As SWIR says, some people have a sense of curiosity about drugs. Kratom's alkaloids are utterly different from those of opium poppies. SWIM has no interest at all in opium but enjoys kratom.

[SouthSideK]

SWIM has an intrest in trying this.

Are there any updated stories from people you know who might have tried this?

SWIM hears that it is great for pain relef and that is what intrests SWIM the most.

[radiometer]

Unless anyone here has a Phd in chemistry I highly doubt your extracting anything from this plant, and if you do have a Phd your not on this forum.

I find that comment rather presumptuous, especially as you have only been here less than four days. I happen to have a masters degree from Yale myself, and I doubt that I am the most highly educated member of this forum. While we're discussing erudition, the word is "you're," not "your." Normally one wouldn't quibble over such a thing, but your post rubs one the wrong way.

Lots of people like to follow quixotic quests out of sheer curiosity, something to be encouraged rather than derided.

Reputation Comments on this post:

Please Hammer Don't Hurt 'Em!