Combinations - 5-HTP with Marijuana

[Nahbus]

So lately I've been taking 5-HTP (about 200mg) 20mins to an hour before
smoking pot. It makes the high a lot more comfortable, clear headed and
alert. It also makes walking very fun.

Anyway, just wondering if doing this often will start to be less
effective, if there is any tolerance with 5-HTP or if it just plain
stops working. I mean it hasn't so far, but if it does I'll be cutting
back on the 5-HTP/Weed combo and save it for good times. Thanks, peace.

[Dogears]

I have no idea, but I have found that 5-HTP make weed very intense.

[Pinkavvy]

swim's girlfriend says the opposite is true for her. she takes 200mg of 5-htp per day and has noticed that since starting the 5-htp treatment, it is more difficult for her to get good and stoned.

[enquirewithin]

Never noticed any difference.

[shagra]

200mgs per day is too much, swim'd say.
swim has found that taking 100 mg approx 1-2 hrs before smoking makes him feel like a pot virgin after smoking a spliff. funtastic!

[enquirewithin]

SWIM used to take 5-HTP but found it made no difference with smoking.

[Moses Gunner]

From a scientific standpoint 5-htp has been shown to prevent the loss of shortterm memory effects caused by Marijuana, probably would help with mood problems caused by pot and increase the sleepy time effects..

[Samadhi]

most of these type "trip or high boosters" are largely placebo... 5htp being a seretonin pre-cursor and processed into seretonin it is unlikely that twenty minutes after taking it that it would have an effect...

Swim feels that 5htp is a good sleep aid and mood leveler but in normal recommended doses.

[Lehendakari]

I've read some monkeys claim that Melatonin (closely related if I'm not mistaken) increases MJ high and makes it a smoother relaxing ride and also it's said to help MJ "withdrawal" and cravings.

There is some evidence of MJ increasing melatonin levels so maybe MJ could lead to some melatonin depletion and 5htp could help in that matter??

SWIM tells me he didn't feel anything differents after a week suplementing himself with 5 mg melatonin at bed time. SWIM smokes daily.

[Digemlo]

Be careful taking melatonin recreationally--in SWIM's experience, too much of it has given him good, deep sleep (especially his first time), and many more times has left SWIM unable to fall back asleep in the morning, cranky, hot, eh. The night before, however, it always has subtle effects on his senses: a feeling of loss of sensation in the body (this only happens if SWIM is going into "sleep mode", lying in the dark, etc, a bit after taking the melatonin), and overall patterns in his dark visual snow--he can't remember right now entirely what it is, but something shifts a specific way in it every time.

[InsaneNcrazY]

5-HTP really helps for sleeping, you begin to develop a circadian rhythm meaning you will have a more restful sleep.
When SWIM takes 100mg before smoking MJ the stone definitely feels stronger and seems to last longer.

[Petethemeat]

SWIM found that 5HTP made his weed sessions much more intense. Yet he often has diffuculties falling asleep after using 5HTP on its own. When he does however his dreams are expecially vivid.

[Mr. Bob]

Bobbers woke up a little dehydrated and miserable (he'd had another bout with the bottle the previous day). No energy, pessimistic, very uncomfortable and unable to fall back asleep.

Enter 5-HTP and some mids (MJ).

He took the 5-HTP on an empty stomic, and within 20 minutes his head seemed to clear up. No depression, a bit more alert, and he's now able do handle his pessimistic thoughts with emotional balance.

Half hour after taking 5-HTP he smoked about half a bowl of some mids. For the first time in quite a while Bobber has a bit of euphoria from MJ.

A complete 180 from when he first woke up, and he thinks he has 5-HTP to thank for it. He does not think the MJ would have done this alone. It seldom does for Bob.

Bob even has the munchies a bit.

[DonerStoner]

may I ask a stupid question? What is HTP?

[Synchronium]

5-HTP stands for 5-HydroxyTryptophan, which is a precursor to 5-HT (serotonin).

Your body produces 5-HTP from L-tryptophan (an essential amino acid) with the enzyme Tryptophan Hydroxylase. 5-HTP is then converted to 5-HT with the enzyme Amino Acid Decarboxylase.

Here's some additional reading:

The importance of aromatic-type interactions in serotonin synthesis: protein-ligand interactions in tryptophan hydroxylase and aromatic amino acid decarboxylase.
Hofto LR, Lee CE, Cafiero M.
J Comput Chem. 2009 May;30(7):1111-5

5-HTP supplements can be used to boost the high from MDMA, smooth out the comedown, potentiate cannabis, improve your mood, help you sleep and help you dream.

[coelho]

A couple of days ago swim took some 75mg of HTP. About one hour later he was feeling very good, and euphoric. Then he smoke some weed, the usual amout he does smoke, and got very high. Swim got even a bit frightened, like he felt the first time he smoked (He used to think he would never experience this again). When the high weared off, swim felt asleep and slept a lot more than usual.
So, in swims experience, 5-HTP actually enhances the weeds high.