mCPP (Piperazine) basics

[Joaspah]

Ik got hold of a few grammes of mCPP, does anybody have any experience with this piperazine??


dosage, effects, duration...???

[William_Again]

mCPP is described by some sources as adding the 'body sensations' aspect of the piperazine MDMA-like cocktail



I got that off erowid.

[Joaspah]

Nobody else info on dosage and duration?


I would like to try it, but i'm not going to try untill i have an idea about dosage.

[Alfa]

Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats.

Life Sciences Department, Bahia State University, 41195-001 Salvador, Bahia, Brazil.

In the present study we investigated the role of central 5-HT2C receptors in the control of blood pressure and heart rate in non-stressed and stressed, adult, male, Wistar rats. Third ventricle injections of the 5-HT2C agonist mCPP elicited a significant increase in blood pressure in non-stressed animals. The initial period of this hypertensive response (10-30 min after mCPP administration) was accompanied by baroreflex-mediated bradycardia, while after this period the coexistence of hypertension and tachycardia was observed. These cardiovascular effects promoted by the central administration of mCPP were blocked by pretreatment with the 5-HT2C antagonist, SDZ SER 082. The administration of SDZ SER 082 alone induced no significant changes in blood pressure or heart rate. The pharmacological stimulation of central 5-HT2C receptors by mCPP did not change the hypertensive or tachycardic responses induced by restraint stress. Conversely, the blockade of central 5-HT2C receptors by SDZ SER 082 blunted stress-induced hypertension without modifying stress-induced tachycardia. It is concluded that the activation of central 5-HT2C receptors induces hypertension in non-stressed rats and that the normal function of these receptors is essential for the rise in blood pressure that occurs in the course of restraint stress.

[Alfa]

Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine in patients with panic disorder and controls.

van der Wee NJ, Fiselier J, van Megen HJ, Westenberg HG.

Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands. n.j.a.van_der_wee@lumc.nl

Oral and intravenous challenge paradigms with the direct 5-HT agonist meta-chlorophenylpiperazine (m-CPP) in panic disorder (PD) have shown only moderate sensitivity or selectivity of the panicogenic effects in PD. However, the results of a study examining the effects of rapid intravenous administration of 0.1 mg/kg of m-CPP in healthy volunteers suggested that this approach may be a more selective and sensitive panicogenic paradigm in PD. We therefore compared the behavioural, neuroendocrine and physiological effects of rapid intravenous administration of 0.1 mg/kg of m-CPP in 10 patients with PD and 10 healthy controls. Panic attacks were significantly more provoked in patients with PD (90%) compared to healthy controls (0%). Effects on the behavioural, but not on the neuroendocrine and physiological parameters, were significantly greater in patients. Our data suggests that the behavioural effects of rapid intravenous administration of 0.1 mg/kg of m-CPP in patients with PD indeed show a unique combination of high sensitivity and selectivity.

[Alfa]

A discriminative stimulus produced by 1-(3-chlorophenyl)-piperazine (mCPP) as a putative animal model of anxiety.

Wallis CJ, Lal H.

Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, USA.

1. This study compares behavioral responses to serotonergic (5HT) agonists and pentylenetetrazol (PTZ) in two behavioral paradigms used as animal models of anxiety. PTZ and mCPP were compared for behavioral effects in elevated plus-maze and interoceptive discriminative stimuli they produce. 2. PTZ is a known anxiogenic drug. The discriminative stimuli of mCPP were selected for comparison because this drug produces "anxiety" in human subjects and "anxiety-like" behaviors in rats, and is a potent agonist at 5HT1B/2C receptors and a partial agonist at 5HT2A receptors. 3. In rats trained to discriminate mCPP (1.4 mg/kg, training dose) from saline, PTZ substituted for the mCPP suggesting the "anxiety-like" properties of the mCPP stimulus. The mCPP stimulus was blocked in a dose-related manner by methysergide, a 5HT2A/2C antagonist but not by the anxiolytic diazepam. TFMPP (a 5HT agonist) and DOI (a 5HT2A/2C agonist) substituted for mCPP, but 1-NP (a 5HT1 agonist and 5HT2C/2A antagonist) did not. 4. In animals trained to discriminate PTZ (16 mg/kg) from saline, mCPP and DOI substituted for PTZ, while TFMPP and 1-NP do not. 5. In the elevated plus maze, time spent on the open arms was reduced by mCPP, DOI and PTZ but there was no significant dose effect of TFMPP, or 1-NP. 6. Methysergide blocked the "anxiety-like" behavior in the EPM. 7. These data suggest that the discriminative stimuli produced by mCPP are based upon its selective actions on 5HT receptors and their use in behavioral pharmacology may offer another tool in studying pharmacology of 5HT based anxiogenic and anxiolytic drugs.

[Alfa]

Discriminative stimulus properties of m-chlorophenylpiperazine.

Winter JC, Rabin RA.

Department of Pharmacology and Therapeutics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo 14214.

Stimulus control was established in a group of 10 rats using a dose of m-chlorophenylpiperazine (MCPP) of 0.8 mg/kg, administered IP, 15 min before training. A two-lever operant task using a fixed-ratio 10 schedule of sweetened milk reinforcement was used. Based upon a criterion for the presence of stimulus control of five consecutive sessions during which 83% or more of all responses were on the appropriate lever, a mean of 27 sessions was required to reach criterion performance. Response rates were significantly suppressed by the training dose of MCPP (14 responses/min) as compared with saline sessions (38 responses/min). Subsequent to the establishment of stimulus control, tests of generalization were conducted with m-trifluoromethylphenylpiperazine (TFMPP), 6-chloro-2-(1-piperazinyl)-pyrazine (MK-212), and 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (RU-24969). MCPP generalized completely to MK-212 and TFMPP at doses of the latter drugs of 0.7 and 1.0 mg/kg, respectively. Maximum generalization to RU-24969 was 67% at a dose of 1.0 mg/kg but only 4 of 10 subjects completed the test session. The present results indicate that MCPP is efficacious as a discriminative stimulus. In addition, because of MCPP's relative selectivity for the 5-hydroxytryptamine c(5-HT1C) receptor subjects trained with MCPP may prove valuable in assessing the respective functional contributions of 5-HT1C sites to the actions of a variety of serotonergic agents.

Reputation Comments on this post:

Thanks for sharing all the info in this thread.

[Alfa]

This means mCPP is a stimulant which increases blood presure, & gives hypertension. Under stressful conditionsincreased heart ratemay be experienced. mCPP is not suitable for people with Panic Disorder.

[Nagognog2]

Or people who don't wish to experience what it's like first hand. Yuk!

[enquirewithin]

Have a look in Erowid-- I'm not sure I would want to try this one,

[JewishNazi]

Try and find some BZP and TFMPP to mix it with. TFMPP shouldnt be a problem but BZP may be a little harder

[enquirewithin]

That very mixture is described here: http://www.erowid.org/experiences/exp.php?ID=2394


Brown urine! Sounds bad!

[hh339]

swim has tried, it was crap.

[Alfa]

HH339; Please define the (dis)qualities of the crap you experienced. Edited by: Alfa

[Boyv]

Name: mCPP
Other names:....
Chemical formula: Formule C10H13ClN2
Weight of the molecule: 196
Looks: Tablets
Farmacological effects: From researches where they compared MDMA, amphetamine and mCPP it’s stated that some persons experience mCPP as a hallucinogen and others as a stimulant. This with the dosage of 0.25 and 0.75 mg/kg (17,5 to 52,5 mg mCPP for a human with 70 kg of body weight). Lab research shows no change in the blood pressure, body or a raising heart beat, while MDMA does give those effects (though these effects can occur while on mCCP).
Farmacological functioning: mCPP only affects the serotonine system, and unlike MDMA, does not affect the dopamine-system. Literature shows us that mCPP is seen as both an agonist as an antagonist. Meaning that mCPP can increase the effects as well as decreasing the effect. Other researchers see mCCP as a substance which can release serotonine from the cells in the brain.
mCPP is used in psychiatry, this to research the possibility that your serotonine-regulation has to do with certain mental problems.
Toxicological effects: Other than MDMA, mCPP is not neurotoxic. OD can lead to being restless, transpiration, overheating of the body and the possible serotonine syndrome.
Toxicological functioning:
Toxicologische interacties: Interacties met andere stoffen die de hoeveelheid serotonine verhogen (zoals XTC of antidepressiva) kunnen leiden tot het serotoninesyndroom.
Dosage: The researches use between 0.25 en 0.75 mg/kg
Other: mCPP is a break down product (metabolite) of the AD Trazodon (Trazolan).

[snapper]

Concur with hh339 - absolute garbage.
SWIM tried with the other three with this (mpp,cpp, bzp, tfmpp) and
alone. The combo was torture and alone was just like being feeling
crappy in a really weird way for quite a while. At the time these were first
released, the feedback from most who tried was similar, and a few had
really bad reactions. These piperazines are really only good as research
ligands.

Snapper

[Thirdedge]

It seems to be all in the mixture, its funny, I have had very pleasant as well as horrible experiences. I think the go with all the piperazines is to PRELOAD with juice and bannanas, avoid alcohol, and make sure you drink plenty of juice or h20 during and after the trip.


Also good to take 5htp over the days before the trip as well as after. And take the trip not too late in the evening or you wont sleep.


But with the right combination, an extremely plesant trip is possible (on the correct mix of BZP,TFMPP, Meopp, Cpp).

[a-SalviaLover]

What about the effects of this substance? Can any one write down further description and comparisons of mCPP? The reports on the erowid are far too conflicting in nature of the experience. Why is there so little info on the net about this substance?

[Alfa]

From Drugnet, Newsletter of the European Monitoring Centre for Drugs and Drug Addiction:

New psychoactive substances

EMCDDA and Europol present joint report on mCPP

In late 2004 and throughout 2005, a new psychoactive substance, 1-(3-chlorophenyl)piperazine (mCPP), was increasingly found in recreational settings in most EU Member States, largely sold under the guise of the popular drug ecstasy.

Although little evidence was available during that period on the public health or social risks of mCPP, 19 Member States and Norway reported numerous seizures.
In line with Step 1 (Information exchange/early-warning) of the 2005 ‘Council decision on information exchange, risk assessment and control of new psychoactive substances’ (1), data on the use and risks of mCPP were collected through the Reitox national focal points and the Europol national units. Meanwhile the European Medicines Agency (EMEA)

collected information on whether or not the drug was used to manufacture legal medicinal products. An EMCDDA–Europol joint report on mCPP was drawn up in October 2005 on the basis of these findings (2). One of the innovations of the Council decision is that, unlike the Joint action on new synthetic drugs, which it replaced in May 2005, it provides for the collection and

exchange of information (but not risk assessment and control procedures) on medicinal products used illegitimately. It stipulates that no risk assessment shall be carried out on a new psychoactive substance if this substance is used to manufacture an authorised medicinal product. Based on evidence from the EMEA that mCPP is used to manufacture at least one

authorised medicinal product (trazodone, a prescription anti-depressant drug), the joint report underlines that no risk assessment can be carried out on mCPP. At this point, action now moves out of the scope of the Council decision and into the realm of an assessment by the European Commission and the EMEA, in close cooperation with the EMCDDA, of the need for further action on this psychoactive substance.

This rapport has been added to the piperazines sections of the files archive. I've also added one about the appearance of mCPP in Slovenia and a document on how the EU handles new synthetic drugs.

[a-SalviaLover]

Very interesting information. From what I understand mCCP works on serotonin in a similar manner like MDMA (except for the agonism of a few types of serotonin receptors). However, it does not act in any way on te dopamine system.

I hope there is someone who has tried this substances write down at least a short description of its effects and duration.

[hh339]

Originally Posted by Alfa

HH339; Please define the (dis)qualities of the crap you experienced. Edited by: Alfa

Headache, nausea, anxeity, fear of death and diarrea. It started out very promising with actual parallels to MDMA like euphoria, nice shivers and such, but <30 minutes later all that was gone and SWIM felt like crap. He also DID CRAP a lot, diarrea indeed. SWIM never experienced fear of death during a drug experience until now, very creepy. SWIM has never experienced this on any other drug and he has taken a LOT of them, mostly psychedelics and xtc. The comedown lasted the whole day after. Hmm what else...yes one more thing, the urge to go take a piss was there all the time, you know like when really cant keep it in and you just HAVE TO GO!! The only problem was that it took maybe 10 hours before it was possible to take piss. Horrible experience.

[DJ-666]

A thumbrule for mCPP is 0,5mg/kg of body weight approximately. But what SWIM read about this chemical there is probably a maximum of 55mg per dose. Further research, experiences posted by forum members would be fine for SWIM too regarding the fact that he has some g´s in hand too...

[a-SalviaLover]

Yes there is certainly not enough info on the net. Many different researches with rats, monkeys etc, but nothing detailed about the effects of human use. The reports on the Erowid are too inconsistent. It seems impossible to be described as a mild psychedelic very similar to MDMA in nature only with a bit more nausea and little less euphoria while others describe very powerful visuals, delusional beliefs and even deliriousness.

I, personally, don't think that it is that bad. The organised crime has no interest in putting a substances that induces great panic in the users, no matter how cheap they would cost, because they won't be bought from the users. And as I read in different reports of pills the rainbows has been described as MDA, MDMA with LSD and so on. And many people in other forums who have tried them misinterpretted it as MDA.

SWIM has the chance of buying large amounts of this substance for a fairly cheap price and he wants to know whether it is worth the effort.

[_caesar_]

SWIM thinks he has come accross this of late. It seems that a large batch of pills (Sharks) being sold off as Ecstacy, are now in Northern Europe.

SWIMs taken a few on a few occasions, up to 7 or eight pills, some users, (the type that dont know what they are talking about never mind feeling ) think they are MDMA. They are not.

Not an enjoyable experiance really, unique but just npt nice, some CEV - patterns etc, maybe some slight object morphing. Sickness agitaion restlessness cramps.

[Orphean]

I'm a little weirded out by the comments that all seem to flow from a couple of extremely bad trip reports on erowid. One by a guy who was obviously having such a bad time he took another pill...while his girlfriend thought it was the greatest thing in her life. The other by Murple who wasn't trying mCPP, he was trying BZP, TFMPP and mCPP together along with GHB. Nothing like a controlled experiment. I could see qualitative comments in some Shulgin dialogue of "I started with 20mg of mCPP and decided that I'd mix it with a bunch of other active piperazines just because I had them laying around".

I'm going to be trying this stuff shortly and hope to post an experience to erowid to give some standalone mCPP feedback with dosages and effects.

In the meantime, I've been reading just about everything I can find about mCPP studies and much of what I've come across simply doesn't gel with the poor reports on erowid. The link below is interesting to note with side effects.

http://www.nature.com/npp/journal/v2.../1395586a.html

"Adverse Effects and Vital Signs
On the whole, mCPP was well tolerated: both standard and low dose caused a mild drowsiness in six patients; three patients reported a mild nausea during the administration of the standard dose (0.5 mg/kg). One of these three patients reported also a late-onset headache (i.e., about 4 hours after the end of the challenge), an adverse effect already mentioned in the literature (Zohar et al. 1987). On the other hand, the low mCPP dose (0.25 mg/kg) did not cause any significant adverse effect. Blood pressure, heart rate, and sublingual temperature did not show any significant variation during the three challenges."



There's no reports of extreme anxiety, crushing nausea or cramps and visions of the apocalypse visiting your bedroom. The "standard" dose would have been around ~35mg for an average male so it's not as if these were small doses of suspect compressed shite.


As for the shark reports, the indication is they have ~22mg of mCPP each...god knows what the other ~170mg is. Something that may leave you feeling sick maybe. Who knows.


I also agree with an earlier poster that if the effects were so terrible, no one would be buying the sharks and taking heroic doses when they're experiencing panic attacks, shitting their pants and dropping to their knees to leave a technicolor yawn on the floor.

Right now, I think the fear mongering is strange and based on poor data. As for people who "know" what MDMA is, that's pretty funny. Unless you're a chemist or have good chemist friends you've always relied on people to give you something that they swear is "good stuff". The fact is very few people know for sure what they are taking and from what I've seen there's a snobbery in "knowing what the real stuff is like and THAT'S NOT IT...but I have it all the time".