kratom and grapefruit juice?

[sands of time]

I have read alot about grapefruit juice potentiating opiates because it binds with the same enzyme as opiates, but what about kratom? I have read on some kratom groups and sites that grapefruit juice works well at potentiating kratom, and in fact I have just tried it out.

I kinda wanna say that I can already feel it hitting me a bit harder, but I think I will need more time to tell. I took a normal dose (1 1/2 tablespoons mixed in pudding) and within 40 minutes the effects were coming on strong. I feel more sedated than normal, but I'm not sure if the grapefruit juice made much difference. I will report back latter. Can anyone else share any experiences? Some people swear by this method.

[snapper]

Grapefruit juice inhibits cytochrome enzymes in the liver that help break
down complex drugs. This became popular with DXM and does indeed
make this sustance stronger. Looking at the compex ring structure of
mytraginine and friends, it is likely that cytochromes work on these.
Therefore, it may work.
To get it to work better, drink about 1/2 liter minimum of PURE grapefruit
(not concentrate) about 2 hours before eating Kratom. The latter kicks in
and out rapidly, and it takes at least 2 hours for the alkaloids in the
grapefruit to bind up the cytochromes.

Snapper

[sands of time]

Wow, thats quite a large amount. It would be nice if there was some sore of extract available, like a vitamin or something. Maybe one could evaporate the grapefruit juice and then drink a smaller amount. Thanks for the info, I did drink a much smaller amount, but the effects lasted longer. Not much more intense though.

[Svperstar]

Funny this topic came up.

Today I just got 90 grams of powdered Kratom, "commercial" grade. I went and got some "100% pure Grapefruit juice, not from concentrate" today to see if it works.

10:00 pm </span>I drank 2 large glasses of Grapefruit juice, and waited 30 minutes.

10:20 pm</span> I pop 1 Generic Extra strength antacid (1000 mgs of Calcium Carbonate.)

10:30 pm </span>I put 2 TSP on the back of my tongue and wash it down with hot water, one TSP at a time, I think a TSP = 4.6 grams

I then chug a sugar free adrenaline rush, which I think is ~80-100 mgs of caffine

I keep doing this once every 15 minutes or so till midnight.

12:00 pm WOW! </span>Hits me like a ton of bricks, I am very, very high, a lot higher than I have been off of Kratom before.

1:10 am( </span>Now)

I still feel it but I am slightly shaky, my hands are shaking pretty bad.

I think I consumed about 30 grams of powder tonight, good stuff. I think the grapefruit juice had a nice effect.

[bcStoner420]

Wow, seems like grapefruit juice is good for a large number of drug potentiations. I think i might have to stock up.

[Red_Baran]

Swim would have to agree, swim loves kratom, and its much better when you drink a nice huge glass Grapefruit in the morning and eat kratom all day long

[sourcream]

superstar noted that antiacid affect the
euphoric effects of kratom of simply assist
with the sickness involved? swim loves caffine while on kratom but have
never used grape juice.



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it be the vitamin content or acids (i.e. would cranberry juice have the
same effect) or does it actually involve grapes? i wonder if just
grapes would produce the same interaction... just thinking to myself

[56hoperoad]

I think it's the DHEA in grapefruit juice.

[signifier]

The potentiation comes from chemicals called Flavonoids which inhibit some cytochrome oxidase liver enzymes.
You can now buy extracted flavonoids in many herb/supplement shops. Look for 'Citrus Bioflavonoids' and 'Querecetin'....

[snapper]

Also, many drugs inhibit cytochromes. A lack of cytrochromes also potentiates many drugs. think about what you are on first (ie - medications) since you may experience a similar potentiation.

Snapper

[lem]

Check this out for more information on grapefruit juice and its effect on cytochrome enzyme inhibition. In short, furanocoumarins (bergapten) and flavonoids (quercetin, naringenin/naringin) are responsible for grapefruit's actions.

http://www.ualberta.ca/~csps/JPPS4(3)/S.Wanwimolruk/grapefruit.htm

Reputation Comments on this post:

Go on then, have an edit button - use it! Nice link btw!

[Marsofold]

Grapefruit juice causes many things to be absorbed into the bloodstream much faster. I used to take Seldane by prescription for allergies. It was removed from the market after it was discovered that taking it with grapefruit juice caused the Seldane blood concentration to reach dangerous levels.

[radiometer]

There is no information available regarding the metabolism of mitragynine, so it certainly may be possible that WGF juice potentiates kratom. It's cool to see anecdotal evidence suggesting it is so...I'll have to give this a try soon.

[Nagognog2]

Oh Bongo? Bongo sweetie? I have a nice and frosty drink for you! Come back here, you damned beast! Stop acting like an ape!

[Richard_smoker]

Radiometer,

the point you bring up is exactly the issue with cytochromes in general--and unless someone does the research on mytragines and how they're metabolized, then we'll only have the anecdotal evidence to add or detract from the idea that grapefruit juice enhances the kratom.

remember, with SOME drugs, the grapefruit juice (if we're assuming it's an active cytochrome inhibitor in this instance) will actually enhance the excretion of the drug.

Some drugs are MORE activated by having a revved-up CYP system. These are usually drugs whose partially metabolized by-product is more potent or equally potent as the parent drug. (hence last year's fad in USA about 'prohormones' before they were quickly banished)