is effectively absorbed sublingually, it works even better insufflated: less of the drug
is lost while waiting for sublingual absorption
Supposedly, one should hold the Bupe "spit-ball" under the tongue for 10 minutes so as to ensure brain penetration of the drug. During this time, its easy to accidentally swallow some saliva, thereby reducing the dose. Insufflation
allows almost the full dose to be absorbed without time limit (assuming one does not sneeze, or blow ones nose).
The downside is a blocked nose due to insufflating the large amount of filler within the powdered subutex
/suboxone (suboxone works well insufflated).
One can use much less of the buprenorphine
when insufflating, as it is a more effective route of administration.