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Beta-Ketones Mephedrone, Methylone, Butylone, Methedrone, Ethcathinone, 3-fluoroMethCathinone (3FMC), Methylenedioxypyrovalerone (MDPV)

 
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  #1  
Old 09-05-2010, 20:32
chemman chemman is offline
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4-ethylmethcathinone (4-EMC) Drug Info

Please post information about 4-ethylmethcathinone (4-EMC) here.

Can anyone add information about:
• names / synonyms
• molecule
• dose
• duration
side effects
• legal status
• have there been any reported incidents with this compound?
• since when has this research chemical been available?
• stability of the molecule / compound

Names: 4-ethylmethcathinone, 4-ethylephedrone, 4-EMC
IUPAC: (±)-1-(4-ethylphenyl)-2-methylaminopropan-1-one

An experiences thread for 4-ethylmethcathinone will be set up when experience reports start coming in.

Research Chemicals Index - Beta-Ketones



-----------------------------------

Hi!
You've heard of 4-EMC? It is a 4'-ethylmethcathinone. The substance is homologous mephedrone. Someone tested it? How do impressions? I've heard that it is more euphoric than the mephedrone. Before swims panda buys, they would like to learn more.

Post Quality Evaluations:
Thanks for bringing this little-discussed drug to our attention.
An interesting new RC. Thank you for prompting discussion on this.
great post about this new substance,thanks for translation!
Attached Images
File Type: png ategor.png (9.1 KB, 1925 views)

Last edited by Phenoxide; 30-06-2010 at 20:14. Reason: brought into standardized drug info thread format
  #2  
Old 10-05-2010, 01:56
Snouter Fancier Gold member Snouter Fancier is offline
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Re: 4-emc

Well, this is interesting. New to me. The few google hits on it seem to be largely from east of the Oder. Another drug site already has a post that calls it 'ephedrone', inviting confusion with methcathinone, which has also been called 'ephedrone'. Great.

Interesting. We may be seeing more of it, if the spread of mephedrone from East to West was an indication of the future directional flow of new chemicals. Have any of the Rumanians on DF run into this one? Experience reports would be welcome.
  #3  
Old 10-05-2010, 15:56
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Re: 4-emc

I found information that a 4-EMC invented in Poland. Has a relatively strong affinity for the receptor 5-HT2b (compared with other bk.) "Queue" ethyl-improves the penetration of the blood-brain barrier.

So far I found a trip-report, but in the Polish language. The person wrote that caused a stronger euphoria than 4-MMC.
  #4  
Old 21-06-2010, 21:30
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Re: 4-emc

are there any further information about 4-ethylmethcathinone ?
  #5  
Old 21-06-2010, 23:03
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Re: 4-emc

Swim believes that 4-EMC can be made in body via ethyl alcohol, as with cocaine and methylphenidate.

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There is no pharmacological mechanis through which this could occur
  #6  
Old 21-06-2010, 23:43
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Re: 4-emc

^^ does swiy have any research to point to for this claim? Or where is the claim comng from???
  #7  
Old 22-06-2010, 00:11
Phenoxide Phenoxide is offline
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Re: 4-emc

Quote:
Originally Posted by PsYcHo-DoUgHbOy View Post
Swim believes that 4-EMC can be made in body via ethyl alcohol, as with cocaine and methylphenidate.
Assuming you are suggesting 4-EMC forms from the combination of alcohol with mephedrone (highly inadvisable by the way..), I do not believe this is going to happen via the proposed mechanism. The metabolic coupling of ethanol and cocaine metabolites to form cocaethylene is a transesterification reaction. Since mephedrone is not an ester, it is not vulnerable to such exchange reactions. Alkyl groups are pretty inert from a metabolic point of view; most of the time they either get chopped off or nothing happens to them at all. Metabolic conversion of mephedrone to 4-EMC seems highly improbable, and the there has been no evidence of 4-EMC in urine samples in the limited animal and human clinical trials already conducted.

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Good clarification
Good, solid info!
  #8  
Old 22-06-2010, 03:32
PsYcHo-DoUgHbOy PsYcHo-DoUgHbOy is offline
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Re: 4-emc

Touche, looked at both cocaethylene and ethylphenidate again, the transformation is on an ester like you said, and the ester is not present with mephedrone. However, what about Methedrone? It has an -OME group that could be converted to an -OEt. However, this would probably cause much more neurotoxicity.
  #9  
Old 22-06-2010, 11:07
Phenoxide Phenoxide is offline
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Re: 4-emc

Quote:
Originally Posted by PsYcHo-DoUgHbOy View Post
Touche, looked at both cocaethylene and ethylphenidate again, the transformation is on an ester like you said, and the ester is not present with mephedrone. However, what about Methedrone? It has an -OME group that could be converted to an -OEt. However, this would probably cause much more neurotoxicity.
Alkoxy groups like the 4' chain of bk-PMMA aren't prone to exchange reactions in the same way as esters. They are far more susceptible to dealkylation, conjugation of the resultant alcohol to glucuronide or sulphate, and even total loss of the alkoxy group. Besides, if by some bizarre quirk of metabolism a reaction like this were to happen, the product would be 4-ethoxymethcathinone rather than 4-ethylmethcathinone.

While it's unlikely to be made from other cathinones in vivo, 4-ethylmethcathinone does sound potentially interesting. Extending the alkyl chain certainly has a significant impact on the 2C family so one might assume there will be notable differences between 4-ethylmethcathinone and mephedrone. If the same sort of relationship holds true for the cathinones then it is possible that 4-ethylmethcathinone has longer activity and higher potency than mephedrone. Whether this would be a good thing is questionable as it would no doubt make the substance less safe, particularly when used to excess.

I'm a little surprised there hasn't been more exploration in this area. This seems like a logical 'next-step' from mephedrone, and would also effectively avoid the law in countries where mephedrone is explicitly regulated without analogue legislation. Perhaps with the US Federal Analog Act and the UK legislation on cathinone derivatives the manufacturers have decided ring-substituted cathinones are a lost cause and are moving into chemical space which is less tightly regulated. Surprising when there are still plenty of territories with people looking for like-for-like replacements for mephedrone.
  #10  
Old 27-06-2010, 13:43
rocker666 rocker666 is offline
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Re: 4-emc

As SWIM is Polish, he was able to translate some interesting reports written by people who tested 4-EMC.

Source: Polish site and forum about psychoactive substances - Hyperreal

Quote:
Originally Posted by murtibing
(...)
4-EMC's pharmacokinetics is similar to mephedrone's pharmacokinetics. M-B would say that because of a longer lipophilic tail, it's able to cross the blood-brain-barrier in a better way.

Secondly, pharmacodynamic stimulation showed that it binds with 5-HT2b three times stronger than mephedrone.

Thirdly, lab rats in Blue Republic liked it very much.

M-B doesn't know how 4-EMC affects the dopamine. He supposes that same like mephedrone.
(...)
Quote:
Originally Posted by Reez
First clinic tests showed that 4-EMC is going to have higher addictive potential than mephedrone.
Quote:
Originally Posted by Reez
Yes, I tested it. Twice.
First time, after consuming 200 mg orally, as it usually is with ketones, the effects appeared after 20-30 minutes. The euphoria was huge, I was able to notice some psychedelic effects, which made me really happy. The euphoria's nature was different than in case of mephedrone. It was clear that serotonin was being released. The euphoria itself was really intensive. After about 3 hours it began to slowly fade (...).
(...) Next time, I started by snorting 100 mg. The effects were similar to those after oral application, however stimulation was present. General influence on heart, I would describe as smaller than in case of 4-MMC. (...) After about 3 hours euphoria began to fade and the compulsive use began (...). Comparing with 4-EMC, mephedrone in my case was weak. When it comes to psychedelic effects, they are really present and stronger as the dose increase. (...)
Quote:
Originally Posted by lucyper2
It's not available in the UK as it's mephedrone's analogue.
Quote:
Originally Posted by pilotpete
(...)
I prepared 150 mg for sniff. (...) It has a really unpleasant, terrible taste.
(...) Euphoria similar to the one I felt during my first time with mephedrone. (...) Works after 10 minutes. Great feeling when listening to some music, it's difficult to focus on anything, pleasant feeling of unreality. (...)
SWIM will add more opinions one day. He hopes he was helpful. If someone wants, he can translate other texts from Polish to English .

Edit (29.06.10):

An interesting post about the route of administration:

Quote:
Originally Posted by Mayday
As it's supposed to have higher affinity for the 5-HT receptors, snorting isn't such a good idea. Despite the fact that when it comes to mephedrone, I reckon that it's a reasonable route of administration and use it myself in order to feel the dopamine, I think that in case of substances affecting the serotonin it's ineffective in comparison with oral consumption. According to previous reports, oral consumption of 250 - 350 mg usually should give satisfying effects.
After reading all those opinions, SWIM became really interested in 4-EMC. As he found a source, he is going to test it in a few weeks and of course describe the effects .

Post Quality Evaluations:
Great job translating accounts that would have been missed by many due to the language barrier.
GReat contribution
great job, translating some experience reports of this lesser-known chemical! as well as the additional info posted in this thread
thank you for taking the time to translate and shed some light on this substance!

Last edited by rocker666; 29-06-2010 at 10:39.
  #11  
Old 30-06-2010, 19:38
girlygrrl girlygrrl is offline
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Re: 4-emc

I have to wonder if this is less likely than 4-MMC to be considered an analogue in the USA.
  #12  
Old 30-06-2010, 20:07
Phenoxide Phenoxide is offline
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Re: 4-emc

Quote:
Originally Posted by girlygrrl View Post
I have to wonder if this is less likely than 4-MMC to be considered an analogue in the USA.
Both are para-alkylated, beta-keto analogs of methamphetamine. Both could be considered similarly analagous to scheduled chemicals, as the length of an alkyl chain doesn't really make a big difference in terms of structural similarity. If 4-EMC has recreational value then it almost certainly would be functionally similar to a scheduled substance too.

So I'd imagine that 4-EMC is just as likely to contravene the Analog Act as 4-MMC. This slight modification seems to have been done to get around the law in several european countries where possession of mephedrone has been explicitly outlawed without the use of analogue legislation. Analog laws will likely treat the two similarly.
  #13  
Old 01-07-2010, 21:15
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Re: 4-ethylmethcathinone Drug Info (4-EMC)

Hi

I take it that would make it legal in the uk ?
  #14  
Old 01-07-2010, 21:31
Phenoxide Phenoxide is offline
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Re: 4-ethylmethcathinone Drug Info (4-EMC)

No. Please see further up in the thread:

Quote:
Originally Posted by lucyper2
It's not available in the UK as it's mephedrone's analogue.
Lucyper2 is correct. 4-EMC is a class B controlled substance in the UK, as it is considered a cathinone derivative under the laws laid out in the amendment to the Misuse of Drugs Act 1971 from April this year.

See 'Which drugs will likely be outlawed by the cathinone ban?' for more information on what is and isn't covered by current cathinone laws in the UK.
  #15  
Old 06-07-2010, 21:24
rocker666 rocker666 is offline
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Re: 4-ethylmethcathinone Drug Info (4-EMC)

SWIM is too lazy to translate more posts, so he just wants to present some other facts about 4-EMC:
  1. Many researchers report that heavy mephedrone users with high tolerance will probably have high tolerance for 4-EMC too.
  2. They are likely to be disappointed with the substance. It may not work or cause too weak effects.
  3. At least month of mephedrone-abstinence is demanded to restore proper organism's functioning and decrease the tolerance (however, for many it might be a too short time-period).

Last edited by rocker666; 24-07-2010 at 20:00.
  #16  
Old 09-09-2010, 16:37
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Re: 4-ethylmethcathinone Drug Info (4-EMC)

Hi Guys. 1st post, ILL do my best. Ok, some guy I met received some of this today. Its quite a fluffy compound, is slightly off white, an not sticky at all. Very little to report so far an they are still investigating the dose an building up slowly. (if cross tollerance is possible they have a very high cathinone tollerance with the ones theyve used in the past) IT BURNS LIKE HELL NASALLY- (more than 2c's.) The taste is a familliar bitter chem smell (though somewhat weak in comparisson 4mmc for example). Its been by eye so far but been up to aprx 70-80mg nasally-(not a good sign, a reasonable taster by). They will wait an hour or so an try a cap with 200mg, hoping that maybe oral may be a better way of administation of this compound.

Last edited by Phenoxide; 09-09-2010 at 16:51. Reason: si
  #17  
Old 16-09-2010, 23:50
rocker666 rocker666 is offline
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Re: 4-ethylmethcathinone Drug Info (4-EMC)

Quote:
Originally Posted by hoff View Post
if cross tollerance is possible they have a very high cathinone tollerance with the ones theyve used in the past
That's not good, Polish RC-users report that people with high tolerance for 4-MMC and other cathinones won't be able to fully experience the power of 4-EMC and it's likely that they won't have any euphoria at all. Unfortunately, beta-ketones tolerance diminishes very slowly.
  #18  
Old 26-09-2010, 04:21
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Re: 4-ethylmethcathinone Drug Info (4-EMC)

SWIM wonders if 4-EMC might replace mephedrone in plant feeder and other branded products like magic, etc that we see in head shops
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Old 05-08-2011, 14:17
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Re: 4-ethylmethcathinone (4-EMC) Drug Info

4-EMC, due to its 'ethyl' group on the phenyl ring is less lipid solubility compared to 4-MMC because of the slightly 'larger size' of the molecule. This means its onset is a little slower also.

Reports indicate that it is LESS potent than 4-MMC but not by much. As a "mephedrone replacement", this is by far the best alternative. 4-MEC and especially 3,4-DMMC don't even come close.

Will start posting in the experience thread soon after I gather all of the data.

MotU
  #20  
Old 25-04-2012, 19:38
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Re: 4-ethylmethcathinone (4-EMC) Drug Info

i will be posting a report on this once i get my parcel i have ordered for my lab!
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Old 28-04-2012, 05:02
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Re: 4-ethylmethcathinone (4-EMC) Drug Info

My cat has had no luck with this compound. On two occasions he tried up to 500mg orally and barely felt anything.
  #22  
Old 12-08-2013, 03:59
Vaya5 Vaya5 is offline
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Re: 4-EMC (NOT 4-MEC!!!) Experience Reports (4-ethylmethcathinone)

Attached is an image of 150mg 4-EMC on a digital scale.
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  #23  
Old 04-11-2013, 20:31
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Re: 4-ethylmethcathinone (4-EMC)

I just tested 4-emc with marquis and it gives no reaction. Which is i think, expected.

  #24  
Old 04-11-2013, 20:46
Rob Cypher Rob Cypher is offline
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Re: 4-ethylmethcathinone (4-EMC)

Allegedly, it's potent at first (at least if you haven't been exposed to 4-MMC or something similarly powerful like that) but loses its luster after a few uses. That's only what I've heard from other people, though. YMMV.
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Old 21-11-2013, 04:41
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Re: 4-ethylmethcathinone (4-EMC)

Quote:
Originally Posted by Rob Cypher View Post
Allegedly, it's potent at first (at least if you haven't been exposed to 4-MMC or something similarly powerful like that) but loses its luster after a few uses. That's only what I've heard from other people, though. YMMV.
This is not my experience, but YMMV!

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