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  #1  
Old 26-07-2006, 19:15
magic_johnson magic_johnson is offline
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is it possible to abuse diphenoxylate? (lomotil)

I was prescribed lomotil for after having diharrhea for about a week. I found out that it contains diphenoxylate which is related to some narcotics such as morphine. To prevent abuse they add atropine to cause unpleasant effects. So I was just wondering if anybody has ever used this drug to get high and if so, is it possible to do a cold water extraction to get the atropine out?
  #2  
Old 26-07-2006, 23:42
Fantasian Fantasian is offline
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Diphenoxylate is potentially a recreational opiate and can be used as such, however when combined with Atropine as is the case in Lomotil when taken in high doses the following adverse effects occur. Diphenoxylate is chemically similar to Pethidine (AKA Demerol)

ventricular fibrillation, supraventricular or ventricular tachycardia, giddiness, nausea, blurred vision, loss of balance, dilated pupils, photophobia, and possibly, confusion, hallucinations and excitation. These latter effects are due to the fact that atropine is able to cross the blood-brain barrier. Because of the hallucinogenic properties, some have used the drug recreationally, though this is very dangerous.

The recreational effects of Atropine are similar to using large amount of any of the other anti-chlolegenic drugs that act as deliriants. It should be warned that using these drug for recreational purposes can possibly induce Terrifying realistic Nightmarelike hallucinations.


As to a CWE im not sure and someone else may be able to answer this. FOrtunatly for SWIF he has very easy access to hospital opiates therefore very rarely uses CWE for anything as he can obtain the pure form. If you want to try the CWE and see if it has worked start with a clinical dose and work your way up, the effects of the Atropine should become very obvious even at slightly above clinical dosages without providing too much discomfort or danger.

These effect most prodominantly observed will be blurred vision.
  #3  
Old 27-07-2006, 00:59
Forthesevenlakes Forthesevenlakes is offline
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also do a search for the "loperamide: sudafed of opiates" thread...if lotamil doesnt readily cross the blood brain barrier there's a few ideas in that thread which might help things work after swiy has done an extraction. great first post.
  #4  
Old 27-07-2006, 01:42
magic_johnson magic_johnson is offline
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does anyone know the solubility of diphenoxylate or if a CWE would get the atropine out?

the fact that diphenoxylate is similar to Meperidine makes me want to try this with atropine
  #5  
Old 27-07-2006, 04:34
Nagognog2 Nagognog2 is offline
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Atropine Sulfate, the usual medical form of atropine, is very soluble in water - 1 gram dissolves in .4ml of H2O.
  #6  
Old 27-07-2006, 07:12
magic_johnson magic_johnson is offline
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Quote:
Originally Posted by Nagognog2
Atropine Sulfate, the usual medical form of atropine, is very soluble in water - 1 gram dissolves in .4ml of H2O.
thanks for the info

do you know if diphenoxylate is soluble in water?
  #7  
Old 27-07-2006, 07:29
Nagognog2 Nagognog2 is offline
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Very slightly soluble in water, so if a monkey had access to extremely fine filter paper, a Buchner funnel, and a vacuum source - it could work. Other wise the monkey should figure that anything over 2mg (milligrams) of atropine will show toxic effects.

Read: Save 'em for when you eat at the cheap place down the street with the cook named Sticky.
  #8  
Old 16-04-2007, 12:09
deekyleeky deekyleeky is offline
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SWIM has an opiate he never heard of....

SWIM found pills and identified them as diphenoxylate, and atropine, can swim takw a few and get same effects as talking a few percocets? Smoke it? chew? snort? swim would like to know if this drug is at all any good.
  #9  
Old 16-04-2007, 12:15
Abrad Abrad is offline
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Re: SWIM has an opiate he never heard of....

The atropine content makes this medicine unsuitable for recreational use. Stick to the recommended dose.
  #10  
Old 16-04-2007, 12:33
deekyleeky deekyleeky is offline
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Re: SWIM has an opiate he never heard of....

well do any swims out there know how SWim could remove the atropine? and if there is a way to sepwerate the 2 substanced, how much would I want to take and what drugs does it resemble most i.e. codein hydro oxy etc....
  #11  
Old 16-04-2007, 14:33
deekyleeky deekyleeky is offline
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Re: SWIM has an opiate he never heard of....

Quote:
Originally Posted by deekyleeky View Post
well do any swims out there know how SWim could remove the atropine? and if there is a way to sepwerate the 2 substanced, how much would I want to take and what drugs does it resemble most i.e. codein hydro oxy etc....
What I really meant to say was how much would swim
  #12  
Old 02-06-2008, 19:46
pinokio pinokio is offline
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REASEC (Diphenoxylate) recreational potential

Hello again, dear science rats.


SWiM (not me for sure) would like to gather any information regarding to possible recreational use of REASEC (Diphenoxylate) which is an opioid agonist. He is interested in especially:

1) possibility of recreational use

2) the (recreational) dose

3) May the combination with 1-2 beers be harmful? (However alc. potentiates itss effect.)


SWiM is thankful for any answers.

pinokio added 1 Minutes and 52 Seconds later...

EDIT:

*however=since

pinokio added 78 Minutes and 2 Seconds later...

EDIT2: 1 tab contains -> 2.5 mg of Diphenoxylate) and 0.025mg of Atropin.

Last edited by pinokio; 02-06-2008 at 19:46. Reason: Automerged Doublepost
  #13  
Old 02-06-2008, 21:05
davestate Gold member davestate is offline
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Re: REASEC (Diphenoxylate) recreational potential

Quote:
Originally Posted by pinokio View Post
EDIT2: 1 tab contains -> 2.5 mg of Diphenoxylate) and 0.025mg of Atropin.
I think you mean atropine, which is a very nasty substance to be dealing with, think high heart rate and nausea. Not sure what doses would produce the nasty side effects, but I'm sure some one can answer that. Diphenoxylate seems to be similar to pethidine so it should have abuse potential, however as atropine can be fatal, wait untill someone else gives you safe dosage levels
  #14  
Old 02-06-2008, 21:18
pinokio pinokio is offline
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Re: REASEC (Diphenoxylate) recreational potential

Yep it is similiar to pethidine, and yes SWIM meant Atropine, sorry.

SWIM has done a little research meanwhile and has found out that 50mg of Diphenoxylate can get "extremely pleasurable opiate-like buzz", however, it also includes 0.5mg of Atropine, but it certainly isn't a fatal dose. Though, the lab rat has been already given the dose (47.5mg D / 0.475mg A).

SWIM is thankful for your reply.

pinokio added 3 Minutes and 23 Seconds later...

Quote:
Originally Posted by davestate View Post
Not sure what doses would produce the nasty side effects, but I'm sure some one can answer that.
The ability of Atropine crossing the blood-brain barrier causes the side effects.

Last edited by pinokio; 02-06-2008 at 21:18. Reason: Automerged Doublepost
  #15  
Old 02-06-2008, 21:54
davestate Gold member davestate is offline
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Re: REASEC (Diphenoxylate) recreational potential

Quote:
Originally Posted by pinokio View Post
The ability of Atropine crossing the blood-brain barrier causes the side effects.
I said how big the dose was not how it causeed the effects

A trip report would certianly be very useful in this instance
  #16  
Old 03-06-2008, 01:06
pinokio pinokio is offline
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Re: REASEC (Diphenoxylate) recreational potential

Quote:
Originally Posted by davestate View Post
I said how big the dose was not how it causeed the effects

A trip report would certianly be very useful in this instance
Ah SWIM is sorry again, misread the thing. The lab rat has been administred the substance at cca 22:00, the effects are said to kick in about T + 02 hours.


The rat will post the feedback for sure (if he survies).

pinokio added 187 Minutes and 50 Seconds later...

The report:
The lab rat has taken 19 pills of REASEC (Diphenoxylate). (cca50mg) and 0.5mg Atropin
0 Tolerance to opoids.

Two hours after ingestion, the rat felt something, but only a very mild opiate feeling. So the rat was given 2 pints of bear, and it went from mild to a lil. more mild, however nothing what would worth the Atropine danger. The ammount of Atropine was 0.5g -> rat didn't feel any effect of it.

Comclusion SWIM can say, diphenoxylate is just not usable for recreational purposes.

Last edited by pinokio; 03-06-2008 at 01:06. Reason: Automerged Doublepost
  #17  
Old 03-06-2008, 01:47
Panthers007 Panthers007 is offline
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Re: REASEC (Diphenoxylate) recreational potential

If each tablet contained .5mg atropine, and SWIM took 19 tablets, SWIM has taken 9.5mg of atropine. This is a toxic level! Cease & desist at once! 10mg of atropine is enough to cause profound toxic effects in the common SWIM. even 4.75mg is enough to cause toxic effects such as blurred vision, flushed skin, cotton-mouth to beat all, and other nasties. 10mg may cause hallucinations of the deleriant variety - seeing things that aren't there which SWIM believes truly are.

Diphenoxylate can/will cause a narcotic high in large amounts. But with that level of atropine it is plainly not worth it. Save 'em for their intended use - a nasty case of the runs.
  #18  
Old 03-06-2008, 01:50
pinokio pinokio is offline
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Re: REASEC (Diphenoxylate) recreational potential

Ah damn, SWIM made mistake again wtf, sorry.

It contains 0.025mg of Atropine ofc. = 0.475mg per 19 tablets.

pinokio added 0 Minutes and 12 Seconds later...

btw why cant i Edit my posts?

Last edited by pinokio; 03-06-2008 at 01:50. Reason: Automerged Doublepost
  #19  
Old 03-06-2008, 02:14
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Re: REASEC (Diphenoxylate) recreational potential

You are a newbie-member. Newbies can't edit. As soon as you make silver, the edit button will magically appear. Keep on going. Soon you will impress someone and you will get enough positive reputation points to transmogrify to silver. Fear not.

Until then you need to call for a moderator to give you an assist with editing.
  #20  
Old 01-09-2008, 18:40
RoboCodeine7610 RoboCodeine7610 is offline
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Re: REASEC (Diphenoxylate) recreational potential

Apparently there already is a thread about this: http://www.drugs-forum.com/forum/showthread.php?t=21280 SWIM has access to scientific filters which he uses to extract codeine... Maybe he could try to do a CWE with Diphenoxylate and collect the powder the remains in the filter. Another use would be taking the pills normally and keeping the dosage of atropine low, and combining it with codeine and they should potentiate each other.
  #21  
Old 09-05-2010, 05:07
PandorymDMT PandorymDMT is offline
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Diphenoxylate

Please post info about Diphenoxylate here.

Can anyone add information about:

* names / synonyms
* molecule
* dose
* duration
* side effects
* legal status
* have there been any reported incidents with this compound?
* since when has this research chemical been available?
* stability of the molecule / compound


Experiences with Diphenoxylate should be posted: Here
These documents about Diphenoxylate are in the file archive: Here
Diphenoxylate pictures can be found: Here
  #22  
Old 20-09-2011, 14:35
lizziepops lizziepops is offline
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Re: Diphenoxylate

I love lomotil. I get a presciption every 30 days for it, that I completely abuse. I used take twenty pills and then two hours later take another ten. It usually takes about 2 hours to kick in, and I get a very speedy, warm opiate feeling. And the best part is that it last forever- like 5 or six hours. I have never felt any of the ill effects from the atropine. And usually I'll still have a bowl movement the very next day, so bad side effects there, either. good stuff.
  #23  
Old 22-07-2013, 20:55
Drewski Drewski is offline
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Re: Diphenoxylate

I have this readily. I do a reverse cd water extraction. Look up cwe and keep the white stuff in the
Filter put it in a Pyrex and wait till it dries. I chisel it out of the dish the pestle and mortar it into a powder. Then add it to a pill capsul. Please note that the liquid strained should be clear. This is the atropine. I throw it out. Also drink a lot of water. It will constipated and bloat you. I take 25 mg each hour up until 100 mg achieved over 4 hrs. Enjoy. This i use mainly for withdrawals. It has a great half life and keeps from the symptoms from effecting me. Said a one eyed snake

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  #24  
Old 22-01-2014, 03:50
Mr. O Mr. O is offline
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Re: Diphenoxylate

Someone took about 50 Lomotil. He felt good for a bit then ended up delusional and walking around for what may have been hours. The next day he didn't know what had been real, what hadn't, nor how/when he made it to bed undetected. It was scary not fun. He said he won't screw with Atropine again.
  #25  
Old 24-01-2014, 00:39
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Re: Diphenoxylate

A friend of a friend's cousin wrote this, and I thought I'd post it in a couple of the Lomotil threads

I have been going through withdrawals for the last 8 days from Subutex... I've been having severe runs because of the w/d's and my dad gave me one of these pills. After finding out what they were, I took 32 of them, not because I am in pain, but because I haven't slept in two days because of the Restless Legs (My arms are actually worse than my legs).

When I stopped taking subs, I was only taking 64th of an 8mg generic bupe per day. I can honestly say that after taking 80mg of Dihyphenoxylate I feel great. I looked up the equivilant in Oxy and Hydro and the two websites I checked gave me an estimate of between 2.6mg and 7.9mg of oxycodone or hydrocodone. I have to say that from the way I feel it seems more like 20-25mg of either. Warm body buzz, definite opiate high. Like I say, the best way I can describe it is a very speedy version of two or three Vicoden or Percs. Very talkative and not sleepy at all, even though I've only gotten 5 hours of sleep in the last two days because of the restless legs.

I ate them without doing a reverse CWE, and the atropine didn't cause any adverse effects. I have drank Hydromet syrup and the hematrope (sp?) gave me a lot of tachycardia and heart palpitations, but I got nothing from the Lomotil. It does take a long time for the onset, for me it took between two and two and a half hours to really feel it, but since the peak, it hasn't diminished at all... it even seems to be gradually increasing still. I know it's very long acting so I won't be feeling bad until the day after tomorrow. It's just nice to take a break from feeling so shitty... after this I won't be taking anything unless I really feel bad 10 days from today.

Anyway, I think you would have to take a whole hell of a lot if you have any sort of a tolerance, but as a few have said before me, it is excellent for treating w/d's. If I would have known it was as strong as it is, I would have only taken half this much.

I think it has great recreation potential, as I mentioned, the atropine didn't effect me at all, even taking 32 pills, and I know the symptoms from taking the Hydromet Cough Syrup. Not the best opioid, but definitely could be used for people in withdrawal or for people with very low tolerance. Could even be used to maintain if you can't find your opiate of choice for a few days. You probably won't feel super high, but you won't be super sick either.

Please keep in mind the delayed onset. If your dog or cat wants to try this, make sure they give the initial dose at least two hours before redosing. You could end up wasting meds, making yourself sick, or worse.

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