Originally Posted by fiveleggedrat
Codeine being smokeable is news to me, but it shouldn't be.
suggest rectal usage/plugging
if one isn't squeamish about that type of thing. Far superior to every type of admin for him except IV/IM.
Thank you for sharing. First Swim heard of this on this board.
Whilst rectal administration of a lot of opiates
results in much greater bioavailabilty and hence absorption this is not the case with codeine
. It has practially the same bioavailabilty orally and rectally ~ 90%. Rectally may be a tiny tiny bit better but with it being 90% orally there is no point going to the extra effort of plugging it.
To get the most out of codeine with promethazine SWIM takes it with some calcium carbonate, magnesium supplements and some loperamide
SWIM is pretty sure you cannot smoke codeine without it being freebased first. Although it may work slightly like smoking cocaine
in spliffs but nowhere near as strong as say smoking crack
which is freebased. Not sure if you could do that with syrup though.
Thread of freebasing it here:
Oh and obviously you can't IV/IM codeine as it will cause a lot of health problems.
Rectal versus oral absorption of codeine phosphate in man
Frits Moolenaar *, Germ Grasmeijer, Jan Visser, Dirk K. F. Meijer
Department of Pharmacology and Pharmacotherapeutics, State University of Groningen, Ant. Deusinglaan 2, 9713 A W Groningen, The Netherlands
*Correspondence to Frits Moolenaar, Department of Pharmacology and Pharmacotherapeutics, State University of Groningen, Ant. Deusinglaan 2, 9713 A W Groningen, The Netherlands
Codeine • Rectal bioavailability • Micro-enemas • Suppositories
Rectal absorption of codeine phosphate from various dosage forms was studied in man. The rectal dosage forms included aqueous solutions and fatty suppositories. A comparison was made with an orally administered solution. The plasma concentrations of codeine were measured by means of HPLC analysis after a single dose of 60 mg codeine phosphate in a cross-over study in 7 volunteers. Compared with oral dosing rectal absorption from an aqueous solution or a fatty suppository produced an almost identical plasma concentration profile with similar interindividual variations. Comparing the absorption rate characteristics it appeared that rectal absorption from an alkaline solution containing codeine phosphate proceeded significantly (P < 0·05) more rapid than after oral dosing. No essential difference in bioavailability was observed between the various rectal and oral dosage forms.
Received: 26 July 1982; Revised: 15 October 1982