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Deliriant antihistamines Diphenhydramine, cyclizine and other antihistamines.

 
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  #1  
Old 30-08-2004, 14:31
psyko_tripper psyko_tripper is offline
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Recreational Use of Doxylamine Succinate?



Has anybody any experience with this substance?


It's an anti-histamine, so the trip will be anything like dramamine/diphenhydramine....


It's a deleriant, so watch out..
  #2  
Old 04-12-2004, 08:12
limpet chicken limpet chicken is offline
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There was a report on bluelight not so long ago on this, the only such report I have read.





Deleriants are nasty substances, usualyl highly toxic, and causing something far from a high, closer to an unpleasant fever hallucination, or acute psychotic episode.


Stay away from deliriants, they are not fun and not worth it.
  #3  
Old 14-10-2005, 18:31
Emperiorjack Emperiorjack is offline
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Recreational use of Doxylamine succinate?

Anyone ever tried this stuff?
  #4  
Old 23-12-2005, 06:36
Fred the Janitor Fred the Janitor is offline
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i have, but not for rec use. i was wondering the same thing
  #5  
Old 23-12-2005, 20:04
sands of time sands of time is offline
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This stuff can destroy muscle tissue at high doses. I would not recommend it.
  #6  
Old 23-12-2005, 20:07
Jeyez Jeyez is offline
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dude, get some xanax or klonapin, or valium.... ur paying for otc sleeping aids to get high, why dont u purchase illegal sleep aids that actually will get u high, and dont mess around with benadryl either that stuff messes u up i felt weird for like 2 days after, its not a hallucinagen but a delerian
  #7  
Old 15-01-2006, 14:30
Aopocetx Aopocetx is offline
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Quote:
Originally Posted by sands of time
This stuff can destroy muscle tissue at high doses. I would not recommend it.
Where did you get that claim? I'm not saying you're wrong but I'm curious. I hope you didn't just hear it somewhere.
  #8  
Old 15-01-2006, 15:01
blindpanda_eric blindpanda_eric is offline
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Absolutely no recreational value.. as with alot of sleeping pills.
  #9  
Old 15-01-2006, 15:22
Aopocetx Aopocetx is offline
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Quote:
Originally Posted by blindpanda_eric
Absolutely no recreational value.. as with alot of sleeping pills.
That's your opinion, but my opinion, along with a lot of others, is that sleeping pills can be a learning experience once in a while. Diphenhydramine comes to mind. That is why I would like to know if doxylamine actually does have any effects.
  #10  
Old 15-01-2006, 17:22
sands of time sands of time is offline
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Quote:
Originally Posted by Aopocetx
Where did you get that claim? I'm not saying you're wrong but I'm curious. I hope you didn't just hear it somewhere.
An overdose of Doxylamine Succinate can cause rhabdomyolysis, which is the breakdown of muscle fibers. The contents of the muscle fiber cells end up spilling into the blood and can cause kidney damage, acute renal failure, and a wide range of other problems.

One of the many sources for this info...

http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Citation

I don't know how much of this stuff it takes to cause an overdose, but this talk of recreational use worries me. What worries me more is that no one seems to be aware of the very real risks of this medication.
  #11  
Old 15-01-2006, 18:26
Aopocetx Aopocetx is offline
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Ah, thanks for the information then.
  #12  
Old 07-06-2006, 01:35
Aopocetx Aopocetx is offline
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I tried it. It made me extremely tired and I only had closed eye visuals. I forget the dose but it was quite high. I fell asleep 4 hours later.
  #13  
Old 07-06-2006, 04:43
jesusfreak666er jesusfreak666er is offline
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not only are delierent a horrible idea, but the one u speak of, i have read at high doses causes muscle deterioration (im not 100%) but thats what i have been told. not only that but it will dry ur respitory system up and possible cause arithmias. plz dont mess with these horrible otc fixes (not talkin about dxm)
  #14  
Old 23-04-2007, 02:56
Orchid_Suspiria Orchid_Suspiria is offline
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Doxylamine succinate for recreation?

Now this isn't something SWIM plans on trying but he is wondering if anyone has just out of curiosity.One would think the effects at high doses would be similar to diphenhydramine seeing they are both anti histamines.
  #15  
Old 23-04-2007, 18:23
Psych0nautPlatinum member Psych0naut is offline
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Re: Doxylamine succinate for recreation?

Yes, they are.

Last edited by Micklemouse; 25-04-2007 at 20:31.
  #16  
Old 23-04-2007, 20:58
x cynic x x cynic x is offline
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Re: Doxylamine succinate for recreation?

Swim isnt too sure about recreational value but it is among the most effective otc sedatives available in the Us, and more sedating than some prescription hynotics. In a study, it was found that doxylamine succinate is possibly more effective than phenobarbital for use as a sedative.For this reason, doxylamine has sometimes been used off label in a manner similar to diphenhydramine for the reduction of anxiety symptoms. The dosage required to induce hypnosis can be as low as 6.25 mg, but is usually effective in dosages of up to 25 mg. Swim wouldnt recommend it for anything besides sedation if thats what swiys looking for.
  #17  
Old 24-04-2007, 18:05
Jatelka Jatelka is offline
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Re: Doxylamine succinate for recreation?

^^^ Does SWIY have a link to the abstract? (Or even better, could they upload the paper to the Drugs-Archive?)
  #18  
Old 26-04-2007, 02:46
AntiAimer AntiAimer is offline
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Re: Doxylamine succinate for recreation?

Hallucinations no. Sedation yes.

Only worth while OTC sleeping aid, in Smurfs opinion. He still needs a extremely high dose but works.
  #19  
Old 26-04-2007, 03:23
svenghali svenghali is offline
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Re: Doxylamine succinate for recreation?

SWIM, in his younger and much much stupider years, bought a box of N*Q*** liquigels or something along those lines. They contained DXM, yes, but they also contained a good amount of doxylamine succinate as well. After a long night of some g-bong hits, SWIM and his friend decided to eat the box of liquigels. Needless to say, they hit the floor in about 20-30 minutes, and woke up perhaps 5 hours later with a TERRIBLE hangover. SWIM feels that he probably took what could be considered a recreational dose, if there is any, of doxylamine succinate, but there were no recreational effects, just some serious sedation.
  #20  
Old 26-04-2007, 04:56
Nagognog2 Nagognog2 is offline
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Re: Doxylamine succinate for recreation?

Doxylamine will knock you flat - that's a given. Hence it's a major ingredient of NyQuil. The product is sold under the premise it will shut you up and make you sleep. See the ads: Barking, coughing miserable husband in bed. Wife can't sleep through his cacophony of a rhino-virus. Feeds hubby some NyQuil. He passes out. Wife sleeps with smile on her face.

Don't play with NyQuil, kids. It also contains a full dose of acetaminophen per dose - 1 gram. You'll sleep - but your liver and kidneys will hate you.

Last edited by Nagognog2; 26-04-2007 at 13:56.
  #21  
Old 27-04-2007, 02:06
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Re: Doxylamine succinate for recreation?

Well . . .

The intranasal route of administration provides a potential useful way of administering a range of systemic drugs. In order to assess the feasibility of this approach for the treatment of nausea and vomiting, doxylamine succinate was studied in rats for the pharmacokinetics (AUC, C(max), t(max)) following intranasal, oral and intravenous administrations. Subjects (six male Sprague-Dawley rats per time interval for each route of administration) received 2-mg doses of doxylamine succinate orally and I-mg doses intranasally and intravenously, respectively. The various formulations were formulated in isotonic saline (0.9% w/v) at 25 +/- 1 degrees C. Doxylamine succinate concentrations in plasma were determined with a high-performance liquid chromatographic assay and a liquid-liquid extraction procedure. Intranasal and oral bioavailabilities were determined from AUC values relative to those after intravenous dosing. Intranasal bioavailability was greater than that of oral doxylamine succinate (70.8 vs 24.7%). The intranasal and oral routes of administration differed significantly from the intravenous route of administration. Peak plasma concentration (C(max)) was 887.6 ng/ml (S.D. 74.4), 281.4 ng/ml (S.D. 24.6) and 1296.4 ng/ml (S.D. 388.9) for the intranasal, oral and intravenous routes, respectively. The time to achieve C(max) for the intranasal route (t(max)=0.5 h) was faster than for the oral route (t(max)=1.5 h), but no statistically significant differences between the C(max) values were found using 95% confidence intervals. The results of this study show that doxylamine succinate is rapidly and effectively absorbed from the nasal mucosa. Copyright 2002 John Wiley & Sons, Ltd.

Here swim discovers doxylamine is more effective intranasal but unfortunately overdose is common and includes somnolence, coma, seizures, mydriasis, tachycardia, psychosis, and rhabdomyolysis. A serious complication may be rhabdomyolysis with subsequent impairment of renal function and acute renal failure. A case has been reported of acute renal failure and acute pancreatitis complication from doxylamine succinate intoxication.

Last edited by x cynic x; 27-04-2007 at 02:18. Reason: Addition of furtherly acquired information
  #22  
Old 27-04-2007, 04:55
Micklemouse Micklemouse is offline
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Re: Doxylamine succinate for recreation?

Is that damage from doxylamine succinate alone or from Nyquill (containing paracetomol)? Citations of those studies would be appreciated, X_Cynic_X, including links & authors where appropriate.
  #23  
Old 27-04-2007, 06:52
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Re: Doxylamine succinate for recreation?

Doxylamine succinate is a very, very effective sedative for me. The problem is that it lasts a very long time so I'll often wake up the following morning still feeling dog-tired. As far as I'm concerned, I might as well have not slept the night before...

I won't use it again unless I'm in discomfort and simply want to sleep through it (like gastro for example). Definitely not if I need to do something productive the following day.
  #24  
Old 02-05-2007, 05:02
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Re: Doxylamine succinate for recreation?

Doxylamine is pretty much the strongest sedative swim's ever taken. 50mg is stronger than 3-4mg of ativan for him. It's also much more restful than most sedatives he's had, and much moreso than diphenhydramine. It can lead to some vivid dreams also which can be pretty fun.
  #25  
Old 02-05-2007, 13:22
Lehendakari Gold member Lehendakari is offline
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Re: Doxylamine succinate for recreation?

So it seems the perfect hypnotic right? No recreative use so no addiction, but still effective to knock a rat out.

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