Drug info - Recreational Use of Doxylamine Succinate?

[psyko_tripper]

Has anybody any experience with this substance?


It's an anti-histamine, so the trip will be anything like dramamine/diphenhydramine....


It's a deleriant, so watch out..

[limpet chicken]

There was a report on bluelight not so long ago on this, the only such report I have read.





Deleriants are nasty substances, usualyl highly toxic, and causing something far from a high, closer to an unpleasant fever hallucination, or acute psychotic episode.


Stay away from deliriants, they are not fun and not worth it.

[Emperiorjack]

Anyone ever tried this stuff?

[jaked588]

i have, but not for rec use. i was wondering the same thing

[sands of time]

This stuff can destroy muscle tissue at high doses. I would not recommend it.

[Aopocetx]

Originally Posted by sands of time

This stuff can destroy muscle tissue at high doses. I would not recommend it.

Where did you get that claim? I'm not saying you're wrong but I'm curious. I hope you didn't just hear it somewhere.

[blindpanda_eric]

Absolutely no recreational value.. as with alot of sleeping pills.

[Aopocetx]

Originally Posted by blindpanda_eric

Absolutely no recreational value.. as with alot of sleeping pills.

That's your opinion, but my opinion, along with a lot of others, is that sleeping pills can be a learning experience once in a while. Diphenhydramine comes to mind. That is why I would like to know if doxylamine actually does have any effects.

[sands of time]

Originally Posted by Aopocetx

Where did you get that claim? I'm not saying you're wrong but I'm curious. I hope you didn't just hear it somewhere.

An overdose of Doxylamine Succinate can cause rhabdomyolysis, which is the breakdown of muscle fibers. The contents of the muscle fiber cells end up spilling into the blood and can cause kidney damage, acute renal failure, and a wide range of other problems.

One of the many sources for this info...

http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Citation

I don't know how much of this stuff it takes to cause an overdose, but this talk of recreational use worries me. What worries me more is that no one seems to be aware of the very real risks of this medication.

[Jeyez]

dude, get some xanax or klonapin, or valium.... ur paying for otc sleeping aids to get high, why dont u purchase illegal sleep aids that actually will get u high, and dont mess around with benadryl either that stuff messes u up i felt weird for like 2 days after, its not a hallucinagen but a delerian

[Aopocetx]

Ah, thanks for the information then.

[Aopocetx]

I tried it. It made me extremely tired and I only had closed eye visuals. I forget the dose but it was quite high. I fell asleep 4 hours later.

[jesusfreak666er]

not only are delierent a horrible idea, but the one u speak of, i have read at high doses causes muscle deterioration (im not 100%) but thats what i have been told. not only that but it will dry ur respitory system up and possible cause arithmias. plz dont mess with these horrible otc fixes (not talkin about dxm)

[Orchid_Suspiria]

Now this isn't something SWIM plans on trying but he is wondering if anyone has just out of curiosity.One would think the effects at high doses would be similar to diphenhydramine seeing they are both anti histamines.

[Psych0naut]

Yes, they are.

[Jatelka]

^^^ Does SWIY have a link to the abstract? (Or even better, could they upload the paper to the Drugs-Archive?)

[AntiAimer]

Hallucinations no. Sedation yes.

Only worth while OTC sleeping aid, in Smurfs opinion. He still needs a extremely high dose but works.

[svenghali]

SWIM, in his younger and much much stupider years, bought a box of N*Q*** liquigels or something along those lines. They contained DXM, yes, but they also contained a good amount of doxylamine succinate as well. After a long night of some g-bong hits, SWIM and his friend decided to eat the box of liquigels. Needless to say, they hit the floor in about 20-30 minutes, and woke up perhaps 5 hours later with a TERRIBLE hangover. SWIM feels that he probably took what could be considered a recreational dose, if there is any, of doxylamine succinate, but there were no recreational effects, just some serious sedation.

[Nagognog2]

Doxylamine will knock you flat - that's a given. Hence it's a major ingredient of NyQuil. The product is sold under the premise it will shut you up and make you sleep. See the ads: Barking, coughing miserable husband in bed. Wife can't sleep through his cacophony of a rhino-virus. Feeds hubby some NyQuil. He passes out. Wife sleeps with smile on her face.

Don't play with NyQuil, kids. It also contains a full dose of acetaminophen per dose - 1 gram. You'll sleep - but your liver and kidneys will hate you.

[x cynic x]

Well . . .

The intranasal route of administration provides a potential useful way of administering a range of systemic drugs. In order to assess the feasibility of this approach for the treatment of nausea and vomiting, doxylamine succinate was studied in rats for the pharmacokinetics (AUC, C(max), t(max)) following intranasal, oral and intravenous administrations. Subjects (six male Sprague-Dawley rats per time interval for each route of administration) received 2-mg doses of doxylamine succinate orally and I-mg doses intranasally and intravenously, respectively. The various formulations were formulated in isotonic saline (0.9% w/v) at 25 +/- 1 degrees C. Doxylamine succinate concentrations in plasma were determined with a high-performance liquid chromatographic assay and a liquid-liquid extraction procedure. Intranasal and oral bioavailabilities were determined from AUC values relative to those after intravenous dosing. Intranasal bioavailability was greater than that of oral doxylamine succinate (70.8 vs 24.7%). The intranasal and oral routes of administration differed significantly from the intravenous route of administration. Peak plasma concentration (C(max)) was 887.6 ng/ml (S.D. 74.4), 281.4 ng/ml (S.D. 24.6) and 1296.4 ng/ml (S.D. 388.9) for the intranasal, oral and intravenous routes, respectively. The time to achieve C(max) for the intranasal route (t(max)=0.5 h) was faster than for the oral route (t(max)=1.5 h), but no statistically significant differences between the C(max) values were found using 95% confidence intervals. The results of this study show that doxylamine succinate is rapidly and effectively absorbed from the nasal mucosa. Copyright 2002 John Wiley & Sons, Ltd.

Here swim discovers doxylamine is more effective intranasal but unfortunately overdose is common and includes somnolence, coma, seizures, mydriasis, tachycardia, psychosis, and rhabdomyolysis. A serious complication may be rhabdomyolysis with subsequent impairment of renal function and acute renal failure. A case has been reported of acute renal failure and acute pancreatitis complication from doxylamine succinate intoxication.

[hork]

Originally Posted by Nagognog2

Doxylamine will knock you flat - that's a given. Hence it's a major ingredient of NyQuil. The product is sold under the premise it will shut you up and make you sleep. See the ads: Barking, coughing miserable husband in bed. Wife can't sleep through his cacophony of a rhino-virus. Feeds hubby some NyQuil. He passes out. Wife sleeps with smile on her face.

Don't play with NyQuil, kids. It also contains a full dose of acetaminophen per dose - 1 gram. You'll sleep - but your liver and kidneys will hate you.

Nyquil Cough only contains doxylamine and DXM, i use it sometimes just as a sleeping aid.

[Micklemouse]

Is that damage from doxylamine succinate alone or from Nyquill (containing paracetomol)? Citations of those studies would be appreciated, X_Cynic_X, including links & authors where appropriate.

[Tortoise]

Doxylamine succinate is a very, very effective sedative for me. The problem is that it lasts a very long time so I'll often wake up the following morning still feeling dog-tired. As far as I'm concerned, I might as well have not slept the night before...

I won't use it again unless I'm in discomfort and simply want to sleep through it (like gastro for example). Definitely not if I need to do something productive the following day.

[ironmics]

Doxylamine is pretty much the strongest sedative swim's ever taken. 50mg is stronger than 3-4mg of ativan for him. It's also much more restful than most sedatives he's had, and much moreso than diphenhydramine. It can lead to some vivid dreams also which can be pretty fun.

[Lehendakari]

So it seems the perfect hypnotic right? No recreative use so no addiction, but still effective to knock a rat out.