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Nootropics Smartdrugs, Brain boosters & Cognitive enhancers.

 
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  #1  
Old 31-03-2010, 23:27
sturdychinfilms sturdychinfilms is offline
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Phenibut...holy shit this stuff actually works!!

SWIM recently ordered a 100grams of phenibut powder. He wasn't really looking to get high (which he didn't) but just to eliminate anxiety. SWIM was afraid that the phenibut would have no effect on him since he had been addicted to alprozalam(xanax) for a while and phenibut seemingly works on the GABA receptors like xanax does. He was wrong. After a dose around 2.5grams he felt great. Anxiety was gone, he was relaxed and comfortable and even had a slight uplifting buzz(not really too apparent though). Only thing that sucks is that it takes about 2 hours to kick in, and for SWIM doesn't fully effect him until 3 hours in. BUT it does last for an incredibley long time. Also, this shit is fucking amazing for sex. SWIM can last almost indefinately on it. But it doesn't delay ejaculation like opiates do by just decreasing pleasure. SWIM still feels everything perfectly but feels he has ultimate control over his ejaculation. Also its pretty cheap too so thats awesome. SWIM is going to experiment with higher dosages to see if he can get some sort of high out of it that people speak of. Also SWIM would like to experiment mixing it with alcohol since the two apparently have synergistic properties. But in conclusion this shit works. If you are an avid user of drugs like GHB or benzos like SWIM then you probably wont get a high out of it. But it will decrease anxiety and make you a porn star in the bed.

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thanks, i have wondered about phenibut
  #2  
Old 08-05-2010, 03:19
Slayerkorn Slayerkorn is offline
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Re: Phenibut...holy shit this stuff actually works!!

It also works very well for SWIM as an anxyliotic. The only major downside is a "hangover" type feeling after using it. SWIM had a throbbing headache and a blah feeling for about 2 weeks after taking pheni one weekend.

Slayerkorn added 5 Minutes and 48 Seconds later...

It also works very well for SWIM as an anxyliotic. The only major downside is a "hangover" type feeling after using it. SWIM had a throbbing headache and a blah feeling for about 2 weeks after taking pheni one weekend.

Last edited by Slayerkorn; 08-05-2010 at 03:19. Reason: Automerged Doublepost
  #3  
Old 08-05-2010, 07:27
fiveleggedrat fiveleggedrat is offline
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Re: Phenibut...holy shit this stuff actually works!!

Phenibut + Glutamine should really prove worthwhile. Glutamine -> GABA.

Works with benzos, alcohol, and such. Why not phenibut?
  #4  
Old 20-05-2010, 01:08
skunkjar skunkjar is offline
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Re: Phenibut...holy shit this stuff actually works!!

SWIM finds phenibut to be extremely helpful for his anxiety. His wife gets the nasty "hangover" effect but SWIM just feels more mellow and less stressed the next day. It should be noted however tolerance builds pretty quick and those 2g doses quickly become 3-5g doses... Also it is said to be nearly as addictive as any other GABA drug so be cautious!
  #5  
Old 22-05-2010, 22:54
zornthro zornthro is offline
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Re: Phenibut...holy shit this stuff actually works!!

SWIM is taking this with aniracetam to see if aniracetam can decrease tolerance build up to the drug. He's been taking 750mg phenibut a day which is kind of a weak dose but does help his anxiety some. He takes it before going to work and will need something to treat his anxiety all summer otherwise he won't be able to continue working. Hopefully keeping the dose small will decrease the rate at which tolerance develops.

There's another drug called baclofen that's very similar to phenibut. Baclofen however doesn't cause tolerance like phenibut does. Maybe phenibut overtime gets metabolised quicker by the liver or something. The two drugs target the same receptors so maybe baclofen is different in that your body doesn't start metabolising it faster over time. Phenibut is also a phenethylamine receptor antagonist so it's also possible that tolerance/withdrawal is caused by interfering with phenethylamine in the brain.
  #6  
Old 22-05-2010, 23:23
Jasim Gold member Jasim is offline
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Re: Phenibut...holy shit this stuff actually works!!

Quote:
Originally Posted by zornthro View Post
SWIM is taking this with aniracetam to see if aniracetam can decrease tolerance build up to the drug.
Is there some basis for this? Source? What's the idea behind this? Where did swiy get this idea?
  #7  
Old 23-05-2010, 15:33
zornthro zornthro is offline
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Re: Phenibut...holy shit this stuff actually works!!

Quote:
Originally Posted by Jasim View Post
Is there some basis for this? Source? What's the idea behind this? Where did swiy get this idea?
I read it on a forum and told SWIM about it. Aniracetam antagonizes ampa receptors which is implicated in phinibut addiction (as well as benzo and opiod addiction). A few people have reported that aniracetam can bring back the original high on phenibut after it seems to have stopped working.

NMDA receptors also modulate addiction for the same reason; these receptors become more active to compensate for the depressant effect of downers. GABAb receptors dont become desensitized so addiction to a GABAb receptor agonist would be entirely modulated through ampa and nmda receptors. As far as I know, at least.
  #8  
Old 12-06-2010, 02:12
imyourlittlebare imyourlittlebare is offline
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Re: Phenibut...holy shit this stuff actually works!!

Quote:
Originally Posted by zornthro View Post
I read it on a forum and told SWIM about it. Aniracetam antagonizes ampa receptors which is implicated in phinibut addiction (as well as benzo and opiod addiction). A few people have reported that aniracetam can bring back the original high on phenibut after it seems to have stopped working.

NMDA receptors also modulate addiction for the same reason; these receptors become more active to compensate for the depressant effect of downers. GABAb receptors dont become desensitized so addiction to a GABAb receptor agonist would be entirely modulated through ampa and nmda receptors. As far as I know, at least.
SWIM wonders about that though. While there has been success using NMDA antagonist and NO synthesis inhibitors to reverse tolerance to opiates, SWIM never heard of similar success with benzos. In that regard, it seems to be specific GABA A subunits that induce tolerance through NMDA (particularly the NR2B receptor subtype) receptor.

As far as phenibut goes, it seems like abstinence should do it. Theoretically, phenibut increases activity at GABA B receptor. Increased GABA B receptor activity leads to decreases in GABA, increased CA2+ channel activity, and decreased GABA A receptor activity. However it also leads to inhibition in certain brain areas. Does SWIY think tolerance may be due to alterations in GABA A activity and extra synaptic GABA levels?
  #9  
Old 12-06-2010, 03:57
mr t mr t is offline
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Re: Phenibut...holy shit this stuff actually works!!

I remember reading in another forum that a very exp,' swimmer' will only do DOx compounds in combination with phenibut,claiming it adds alot to the euphoria factor
  #10  
Old 12-06-2010, 17:13
JaWill88 JaWill88 is offline
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Re: Phenibut...holy shit this stuff actually works!!

yes phenibut is an incredible substance. used it for a long time but then just got baclofen which is almost the same, but works a little better, and tolerance never seems to build. but phenibut is amazing. swim couldn't believe he didn't have anxiety after taking it, considering he has used many benzos (mainly clonazepam) for many years. and even after using benzos recently, that stuff does the trick. i give phenibut and A+ in my book. just cant use it for more than a few days, without a few day break. swim likes to use high doses like 10grams at a time. that really kills anxiety all day. and it will also potentiate some other gaba agonitsts, mainly gaba b agonists (ghb, baclofen, ect.)
  #11  
Old 13-06-2010, 02:46
DiabolicScheme DiabolicScheme is offline
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Re: Phenibut...holy shit this stuff actually works!!

Read new post below..

Last edited by DiabolicScheme; 21-11-2010 at 03:44. Reason: Found out the product SWIM had was a fake, so this is a inaccurate experience report
  #12  
Old 13-06-2010, 05:11
NeuroChi NeuroChi is offline
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Re: Phenibut...holy shit this stuff actually works!!

It is a strange blend of alcohol and a weakly anxiolytic benzo like lorazepam. Mild co-ordination impairment at 3 grams, with some relaxing anxiolytic effects on the mind and comfortable body buzz. Somewhat fuzzy headspace and potent effects on vision. Hardly something someone could ever safely drive under the influence of.
  #13  
Old 13-06-2010, 05:18
imyourlittlebare imyourlittlebare is offline
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Re: Phenibut...holy shit this stuff actually works!!

Its ridiculous to me that phenibut is considered a nootropic. It impairs short-term memory tasks in animals, the memory impairments are reversed through the use of scopalamine, and GABA B antagonists enhance learning/memory.

SWIM wonders how this myth got started? Perhaps helped with performance anxiety on certain tests and particular ppl scored better? any SWIY know?
  #14  
Old 13-06-2010, 06:17
NeuroChi NeuroChi is offline
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Re: Phenibut...holy shit this stuff actually works!!

I understand it help with sleep, which can be viewed in itself as a nootropic (or counter-nootropic) since some of them provide stimulation and phenibut could be used to counter this.

Some data exists on phenibut as a nootropic in the classical sense though; it is used in Russia in place of Ritalin for those with ADHD, and has been compared to piracetam in effects.

Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug

Some of the studies quoted in the following passage are somewhat relevant, though it seems to jump to the conclusion that it is a nootropic because it enhances performance on a passive avoidance test. Personally I'm not convinced that will mean if I take it I will perform better on memory tests or cognitive ability, but hey, to each their own I suppose.

Quote:
Nootropic effects. Although phenibut does not meet all the requirements of a nootropic, it does have many similarities to piracetam. In mice, phenibut causes significant improvement on the passive avoidance test [2]. In this test of memory, animals are put in an undesirable area (such as a lighting situation or height from the floor that that species dislikes), and then given a negative stimulus (such as a shock) when they exit that area. Their ability to stay in the original area reflects how well they remember that if they exit it, they will receive the undesirable stimulus. Phenibut also improves performance on the swimming and rotarod tests and antagonizes the amnestic effect of chloramphenicol [2]. It also has an antihypoxic effect, a trait commonly seen among nootropics [17]. However, in one study, phenibut was ineffective in the water maze and shuttle box tests, while piracetam was [18]. Other research supports the idea that phenibut has nootropic activity similar to that of piracetam, but not as strong [19]. Nootropic activity has also been reported in humans [2], but it was not specified whether these were healthy adult humans, and they were probably elderly or psychiatric patients.

Another trait phenibut shares with nootropics is neuroprotection. Multiple animal studies have indicated that phenibut administration increases resistance to the detrimental effects of edema on mitochondria and energy production in the brain [20-22]. Phenibut also normalizes brain energy metabolism changes caused by chronic stress [23]. It was found to prevent changes in plasma electrolytes caused by cerebral injury [24]. Phenibut also protects dopaminergic neurons, and improved the condition of patients being treated with antiparkinsonic drugs [25].
Source.

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  #15  
Old 14-06-2010, 01:56
sarita78 sarita78 is offline
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Re: Phenibut...holy shit this stuff actually works!!

Swim was rx'd baclofen last year and took it for a good many months. Swim found it helped her sleep in large quantities but didn't do much else. Swim tried phenibut for the first time yesterday and was extremely impressed! She had read how it is closely related to baclofen. In her experience she did not see the similarity. Phenibut not only produced benzo-like calmness, it lasted for hours!!! And swim was able to sleep for 10 hours. That in and of itself is a huge feat for swim. She has suffered insomnia for over 17 years with very few things helping her. Very impressed with phenibut.

It should be noted swim took phenibut with tramadol. Also when swim was taking baclofen it was in conjunction with dangerously high dosages of tramadol as well.
  #16  
Old 24-07-2010, 11:02
imyourlittlebare imyourlittlebare is offline
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Re: Phenibut...holy shit this stuff actually works!!

SWIM always wondered why and how phenibut was considered a nootropic? Its only in Russian literature where they propose this idea. And since it does work similarly to Baclofen, SWIM knows that BAC causes severe memory deficits in rats (The GABAB receptor antagonist CGP36742 attenuates the baclofen- and scopolamine-induced deficit in Morris water maze task in rat). Not to mention that BAC has aversive qualities similar to lithium chloride (from original research swim is presenting at society for neuroscience this year)

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Sources would be nice.
  #17  
Old 26-07-2010, 04:27
imyourlittlebare imyourlittlebare is offline
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Re: Phenibut...holy shit this stuff actually works!!

The GABAB receptor antagonist CGP36742 attenuates the baclofen- and scopolamine-induced deficit in Morris water maze task in rat is by Y Nakagawa

As far as original BAC research goes, the poster wont be available for a little while. But theres a world of research on the negative effects of BAC on memory and the positive ones of GABA B antagonists. A good starting place is the above article.
  #18  
Old 28-07-2010, 23:05
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Re: Phenibut...holy shit this stuff actually works!!

Would the effects of Phenibut be increased if one injected it ? SWIM noticed that the bulk powders he has dissolve very well in water and are not cut with extraneous "stuff" like the pills. Is there any evidence that this mode of administration would work better? Please note that I'm not recommending this. This simply for curiosities sake.
  #19  
Old 10-08-2010, 20:41
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Re: Phenibut...holy shit this stuff actually works!!

is phenibut good for sex?

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The only posts that I have seen from you have pertained to sex, while you are posting in a forum that is designated to nootropic drugs which are meant for cognitive, NOT sexual, benefit.
  #20  
Old 21-11-2010, 04:16
DiabolicScheme DiabolicScheme is offline
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Re: Phenibut...holy shit this stuff actually works!!

SWIM had a previous experience report, well come to find out the product was a complete farce and seemed to be reported as simply a GABA product.

SWIM feels the need to make people aware that this product can turn on SWIY very quickly if caution is not taken when dosing. Its not just the withdrawal symptoms you need to worry about.

SWIM has since tried a different brand that yielded a much different effect, SWIM has two experiences to share one was great, the 2nd went horribly bad.

EXPERIENCE 1 - THE GOOD ONE
SWIM began taking phenibut two weeks ago and wanted to get a good nights sleep, SWIM took 1,800MG his first time. Took approx. 2 hrs before it took effect but man was it amazing. I felt incredibly relaxed, alcohol/xanax like feeling but with no brain fog. SWIM experienced this feeling for about 3-4 hours because he liked the feeling he decided not to go to sleep right away. Seriously, this product was single handedly THE BEST anti-anxiety medication SWIM has ever had. Clear headed, calm, and relaxed.

EXPERIENCE 2 - THE BAD ONE

SWIM tried it again another day, took the first dose of about 1.5MG at around 2PM during the day since SWIM was going out to a birthday party he didn't want social anxiety to creep up.

This kicked in perfectly at 4PM when the party started, SWIM would also like to add that he took 6G of Bali Kratom as well to make SWIM more sociable. SWIM was completely relaxed, nothing could bring me down and it wasn't strong enough to make me want to dose off.

SWIM got home around 6PM and this is where it took a turn for the worst, thinking the stuff was starting to wear off [Kratom perhaps made SWIM think it was since Kratom is a slight stimulant for SWIM] he redosed with another 1.2G.

Everything went fine until 8PM came around, SWIM felt completely drunk off his ass. SWIM became dizzy and slightly nauseous. At this point the only thing SWIM could do is lay in the bed because he pretty much could no longer function. Best way SWIM could describe this feeling is being WAY too drunk and getting the "spins" with the added benefit of cognitive functions being way too clear. In other words, SWIM remembers it clear as day.

9PM came around and SWIM threw up all his food in his stomach to the point there was nothing left and SWIM was dry heaving.

9:30PM was a repeat of throwing up, but there was nothing in SWIM's stomach thus dry heaving.

..30 minute increments until about 6 in the morning SWIM was visiting the toilet, SWIM probably heaved about 10 to 15 times and in between these SWIM was nodding off but due to fear of what was happening SWIM fought to stay awake which SWIM did so successfully most of the night.

By 10AM the next day the dizziness FINALLY subsided, but the effects were not over with SWIM could still feel the sensation of the calmness this stuff gives in proper doses. SWIM slept until 8PM that night and woke up to go to work.

It wasn't until 11PM when the stuff finally completely wore off. On the bright side SWIM never experienced the supposed horrible after effects when the stuff wore off, in fact SWIM experienced more of an afterglow in which his mood seemed much better the following day after dosing.

Some suggestions:
- DETERMINE SWIYs dosage and don't jump right in and take more than 2 grams or SWIY could be vomiting drunk for 14 hours and remember it all of it clear as day. Which SWIM's opinion makes it 10x worse. As it has been said its easier to increase a dose than it is to decrease a dose once SWIY has already taken it.

- Phenibut is tricky, don't assume because it hasn't kicked in 30 minutes after taking it that SWIY needs to take more. WAIT at least 2 to 3 hours before determining that SWIY needs more, even then increase doses SLOWLY.


- SWIM does not recommend one to REDOSE until at least 24 hours have passed since the last dose as this stuff will build up and doesn't wear off quickly like say Xanax.

- If SWIY has a addictive personality, please avoid this product. This product in SWIM's opinion should not be taken lightly just because it is legal.

Be SAFE SWIMMERS!

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valuable report on high dose of gaba B agonist + opioid
  #21  
Old 05-12-2010, 07:50
Lollante Lollante is offline
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Re: Phenibut...holy shit this stuff actually works!!

In SWIM's experience (and that of his extended friendship group) there is addiction and severe withdrawl associated with Phenibut, including but not limited to insomnia and panic attacks.

SWIM suggest handle with care, particularly re: dosage and frequency of use. SWIM suggests 500mg - 1g is more appropriate than 1.5 - 2
  #22  
Old 31-01-2011, 20:06
gmeziscool2354 gmeziscool2354 is offline
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Re: Phenibut...holy shit this stuff actually works!!

this is a note i found written by a student in my psych class his name is zxc

zxc is a relatively experienced drug user, however is is currently in a lull period for his DOC, marjiuana, it doesn't fit with his lifestyle ATM. He has gotten into herbs and nootropics, looking mainly for things that he can use while at work, class or the gym that are legal and won't decrease his perfomance or get him fired. Hes settled on a few things, 5-htp, melatonin (for sleep), kratom, adrafinil, kava and most recently phenibut. he definitly doesn't take all of these every day; hes cycles, tries not to make to much of a regular habit out of any 1 thing but this EXP is more focused on phenibut.

after doing some research, swim decided his best bet for phenibut was a product called Relax All with phenibut. this is a low dose of phenibut and some other vitamens, herbs and nootropics in a 000 gel cap. hes not looking to 'get high' on the stuff, but more nootropic properties. he knew he could get this product at his local 'nutrition' store from veiwing the their online catalouge. he purchased the 60 capsule bottle. from the dosages they reccomend 1-4 a day, using no more than 5 days in a row and taking a break of atleast equal time inbetween.

any way, he gets home and starts with 2, chills out for a while, takes a nap and about 2.5 hours after taking goes to the gym, popping 1 or 2 more before he goes. midway through the workout he starts to get some really "good" feeling in his muscle particularly the ones he had been using, his thighs from biking and his chest from weights. this good feeling continued to build until he he felt very 'relaxed' almost like a low dose benzo. he wouldn't say it increased or decreased his performance, but he certainly felt alot better doing it. any way, by the end of the day he had taken 5 and found these caps actually provide enough phenibut for him to 'feel' it, which he wasn't expecting.

so that was his first time experience,after that he cotinued to cycle it, time on, egual time off. one interesting thing to note is the 'sweet spot' for him; he can take his last dose abut 60 hours after his first, he stakes a few to start out, but can continue the effects by taking less and less until he hits the point the notorious "phenibut short term tolerance" issues start to take effect. basically, day one take 4, day two 2 and day 3 1; effects will last all of the 3rd day

any way about combinations, he found good combinations with these nootropics and herbs and some other drugs. First of all, phenibut exhibits strong synergy with kratom. phenibut seems to increase the strengh and duration of the kratom experience, together they create and extremely calm focused mind state with a lot of 'comfortable' energy. phenibut lasts longer and has a takes a lot longer to come up, so its reccomended to take phenibut first by a few hours. EDIT: note all experience involve relaxall with phenibut

phenibu and kava produces a strong feeling, but its not as synergistic with kratom. both seem to act as the would with out much of a significant reaction

phenibut makes him drink much slower, nothing to note beyond that for him

phenibut seems to increase the effects of stimulant drugs, perhaps by decreasing the side effects or reducing the unpleasant aspects of the stim.

So hopefully this can help someone

Post Quality Evaluations:
great post with a good assortment of information

Last edited by gmeziscool2354; 02-02-2011 at 03:25.
  #23  
Old 29-04-2011, 03:52
zornthro zornthro is offline
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Re: Phenibut...holy shit this stuff actually works!!

Quote:
Originally Posted by DiabolicScheme
EXPERIENCE 2 - THE BAD ONE
...
Phenibut builds up in the system so just because the initial high seems to have worn off doesn't mean the drug isn't still doing stuff in the brain. "Chasing" a phenibut high with more phenibut will just make you really tired.

It's great for sleep, social occasions and anxiety but if someone wants a drug with a more "high" effect I would recommend (through my friend's advice, I stay away from this kind of stuff) something like kava, or maybe combining the two.
Quote:
Originally Posted by imyourlittlebare
SWIM wonders about that though. While there has been success using NMDA antagonist and NO synthesis inhibitors to reverse tolerance to opiates, SWIM never heard of similar success with benzos. In that regard, it seems to be specific GABA A subunits that induce tolerance through NMDA (particularly the NR2B receptor subtype) receptor.

As far as phenibut goes, it seems like abstinence should do it. Theoretically, phenibut increases activity at GABA B receptor. Increased GABA B receptor activity leads to decreases in GABA, increased CA2+ channel activity, and decreased GABA A receptor activity. However it also leads to inhibition in certain brain areas. Does SWIY think tolerance may be due to alterations in GABA A activity and extra synaptic GABA levels?

Read more: http://www.drugs-forum.com/forum/new...#ixzz1KsM2ROtA
A friend of mine used phenibut for about 2 months at work dosing only 800mg and eventually quit cold turkey. He never had a chance to try anything like aniracetam for withdrawal but he didn't need it anyway. Withdrawal started almost exactly 24 hours after the last dose and lasted maybe 5 days. Phenibut tolerance probably went down immediately after that. During the initial withdrawal period my friend said he felt really awake/confident and was able to focus really well, almost like he had taken a really good nootropic. The next day however those effects had passed and he had something of a sore feeling but nothing major.

Due to GABAb modulating pain more than GABAa I would have to assume GABAb is a major component of withdrawal. However another component might have to do with the phenylethylamine system readjusting itself. Phenibut is a phenylethylamine antagonist, unlike baclofen which anecdotally has less of a withdrawal risk. Some people have suggested that PEA supplementation along with phenibut might prevent tolerance to the drug. I'd like to get my friend to try that experiment but he doesn't really seem like he wants to. It would involve a lot of controlled trial and error to get the right long-term doses.
  #24  
Old 26-10-2011, 13:10
zodiac5 zodiac5 is offline
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Re: Phenibut...holy shit this stuff actually works!!

Greets, everyone.

I have recently decided to delve into phenibut as the GABA-ergic of choice to support my amphetamine-prescription + support stack. I've set out to compare its efficacy with that of baclofen in this sense, and perhaps address some finds regarding its tolerance. The aim of the stack is essentially to promote therapeutic anxiety/focus enhancement through steady NMDA/AMPA glutamatergic modulation and maintained receptor sensitivity.

That is sort of the brief background description, as I don't want to go into 800 paragraphs of detail, but suffice it to say that I've found this discussion thread to be both very informative and insightful and so thought I would add my two cents wherever possible.


My stack currently involves amphetamine prescribed @ 30mg per day, spaced apart in 5-10mg increments - with a long-acting NMDA antagonist of choice (acamprosate) to maintain a ceiling, and further glutamate modulation/activation coupled with piracetam to maintain sensitivity. This stack works very well for me along all criteria (I have long-standing endocrine 'issues' that arise as a result of lacking glutamatergic coordination causing catecholamine excess in certain regions, and these issues are readily reversed, right down to my skin health, by this complex). It is all still up in the air, and further tweaking is always being done for the sake of gaining knowledge and being able to help others in the future; to this end, recently, I have taken on a GABA-ergic component to the stack, which first included only a "B-100" vitamin complex (100mg of all the B's, which includes B-3/B-6, and generally induces a very pleasant relaxation that counters most types of anxiety/jitters, aids digestion, etc.) but recently involved the introduction of phenibut (to incredible results).

Alas, a few initial observations: amphetamine with phenibut is most definitely different than either alone, in terms of positive effects -- less jitters than amphetamine alone, yet slightly less drowsiness than phenibut alone -- in low dosages (250mg phenibut bid to go with the 5mg amphetamine 6x daily).

Piracetam 800mg spaced apart every few hours or so (while on its own being mostly unnecessary for me, and definitely anything but "positive") greatly aids in bringing about more of the positive effects of the stack. This is referring to "positive" in terms of mood, focus, and enhancement of good criteria with less unwanted effects, etc.

This stack gives light to some of the theory behind potential "PEA + phenibut" combinations, as well as the "-racetam + phenibut" ones, and while much of this is simply initial observations, I will do my best to update on things (whether more scientifically or just as musings/results) as they arise. I have not yet worked with altering or increasing dosages (decreasing frequencies) of either amphetamine or phenibut in this stack in order to keep everything consistent, nor have I really addressed anything in regards to the infamous "tolerance" that has so often been reported to develop to phenibut after a long time.. (and I am using it daily, which might further exacerbate things and lead down that path, unfortunately -- I am aware).

Alas, hopefully this serves as some background and provides some initial confirmations.

Additionally, the post above stating that NMDA antagonism will thoroughly help to reverse tolerance to the effects of GABA-B agents... is very much on the money. This has been a consistent anecdotal observation of my own and for several others. However, it is to be noted that (as probably expected) this really only applies in relation to the sedative effects of GABA-B agonists. In the case of something like phenibut, there is definitely more at play than just the sedation aspect, and while many of us of course wish that there was a bit more development in the body of research behind this substance, this is simply not the case.

What is true is that it is more than likely indeed a PEA antagonist (downstream, at least) and most obviously a GABA-B agonist. The rest is more of open to interpretation, theory, anecdotes.

*** I am not a medical professional, just an amateur psychopharmacology enthusiast and a student of mind-body integration, so please accept my interpretations with the corresponding varieties of grains of salt henceforth... >;D ***

More soon...
-z
  #25  
Old 27-10-2011, 09:45
badbunny30 badbunny30 is offline
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Re: Phenibut...holy shit this stuff actually works!!

Quote:
Originally Posted by DiabolicScheme View Post
SWIM has two experiences to share one was great, the 2nd went horribly bad.

EXPERIENCE 2 - THE BAD ONE
My Bunny having used Phenibut and Kratom over a number of years now, would suggest that the bad experience was actually the Kratom and NOT the Phenibut.

My Bunny once took a dose of Kratom and feeling fantastic, not wanting to loose that feeling re-dosed a couple of hours later. Within 1hr of the second dose she experienced all the feelings you described. Dizziness which one would normally associate with too much alcohol, and an awful nausea, although she didn't puke, she spent 4-5 hours laying on the bed feeling very much like she would.....

Never has she experienced this with Phenibut

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