Oral use - New Sleeping Pill! Rozerem (Ramelteon)

[Ambient1]

Has anyone tried the Rozerem? It's the newest sleeping pill on the market. Unlike mosthypnotics (Ambien, Sonota,Lunesta) that work on GABA receptors, Rozeremworkson melaton receptors. Thus, I don't know if it will have any euphoric effects or even any at all. If anyone has any experience with it, I'd really like to know about. Thanks.

[soma]

i second this. my online pharmacy has this in stock

[armatitumor]

What is the difference between taking Rozerem and taking Melatonin? I
take Melatonin every night before I go to bed, and it almost always
cures my insomnia. Would Rozerem work even better for me, or is it the
same as a high dose of melatonin? Also, I assume its prescription, not
over-the-counter?

[blindpanda_eric]

Melatonin works for me, but when I take it for a week, it doesnt work any longer.



This is weird... drugs.com has some info.

[Ambient1]

Here’s my full report on Rozerem:

Participant Information

175 lbs @ 5’11”

Previous Prescriptions: Chloral Hydrate, Doxepin, Lunesta, Respirdol, Seroquel, Sonata, Trazodone, Vicodin

Current Prescriptions: Effexor XR, 150mg daily, Wellbutrin XL, 150mg daily, Ambien, 10-15mg before bed as needed, Xanax, 0.5mg 1-3 times per day as needed

History of Alcoholism or Illicit Drug Use: None</LI>[/list]Experiment 1:

Participant went through 4 day “wash-out period” from Ambien and Sonata before experiment began.

T+0:00 Ingested one 8mg capsule.

T+0:30 No effect. Ingested another 8mg capsule.

T+1:00 Still no effect. Ingested another 8mg capsule.

T+1:30 Still no effects! Experiment terminated.

Comments: This is highly disappointing. I had a lot of hope for this drug. In the future, it may add to our knowledge-base if we had experiments involving:

1. Higher dosages at once
2. Chewing them
3. Snorting them
4. Mixing with alcohol/dissolving them in alcohol
5. Mixing with other hypnotics
6. Mixing with benzodiazepines, particularly Xanax

[kemistudent]

New on the scene, my doc just ordered me 8mg pills to get to bed. The first night sucked, although I fell asleep on a cloud, I woke up every hour on the hour!! I was pissed.

Second night took 2, much better, crashed nicely, a good 14 hours or so. Maybe too long.

Will try 1.5 tonight. Maybe I can get this to 9 hours and I will be happy.

Anyone else heard/tried this medication?

[sands of time]

I thinks this mediction is going to usher in a new era of insomnia treatment. It's action is very unique, being a melatonin MT 1 & 2 receptor agonist. Many reps claims it's about 10 times as strong as melatonin itself. The main advantage for doctors is that it's reported to have no abuse potential. This medication is quite interesting, but I'm not sure it compares to ambien, lunesta, and all the others as far as it's effectiveness. Please continue to share your experience.

[kemistudent]

Please continue to share your experience.

I slept for 15 hours yesterday.. woke up and got in a dispute with my (x) fiancee and then felt great. I have to play a bit more to give an accurate report, but I can verify that 8mg is not enough to knock ya out, 16 does nicely.. maybe too nicely though.

[Benzeneringz]

So there is a noticeable effect from these pills? Melatonin has never done anything to me; in Alexander Shulgin's words, "I took melatonin and slept great. The next night I didn't take melatonin and I slept great. Why waste the money?" It must be a unique feeling since Melatonin receptors aren't touched on anywhere else.

[Bio-Cellular Enigma]

SWIM recently came across a few of these. Small, light-yellow tablets with "TAK" written across the top (Takeda pharmaceuticals) and "RAM-8" across the bottom.

They are certainly not recreational, and they don't seem to produce much drowsiness or tendency toward sleep either. This strikes SWIM as an unusual case of a pharmaceutical company 'hijacking' a substance already sold for a long time (in this case, melatonin) and getting away with it because of an existing market demand for a non-scheduled and 'non-addictive' sleep medication. There are apparently no published studies showing ramelteon to be more or less safe/effective than melatonin.

Wikipedia claims this: "The obvious advantage of ramelteon is that the product and dosage is more likely to be pure and standardized, because it is a patented prescription drug that is monitored by the Food and Drug Administration (FDA)." SWIM sees this as merely a potential advantage, not an obvious advantage. He assumes it is possible to acquire pure, pharmaceutical-grade melatonin.

[SuprSonik]

SWIM was prescribed this a couple months back. It wasn't covered by his insurance and a 1-month supply cost quite a lot. After using the sampler he was given (7 pills), SWIM promptly threw the prescription in the trash. SWIM was frustrated that his doctor wanted him to pay so much (the doctor knew SWIM's insurance didn't cover it) for what is little more than pharmaceutical grade melatonin.

[Bio-Cellular Enigma]

SWIM believes the whole selling point of this stuff is the fact that it's not scheduled and "non-addictive," which would look attractive to some doctors in a market dominated by sedative-hypnotics. He hasn't tried it specifically for insomnia though, so this isn't personal experience talking. The price SWIY mentioned (careful, I think mentioning prices is against the rules, although this may not be what the rules refer to) is actually fairly inexpensive for a months's supply of brand name sleep medication. Lunesta or Ambien can cost twice that much.

It actually seems strange though that Takeda "got away with" Rozerem; imagine another company selling pharmaceutical-grade 5-HTP or St. John's Wort. Why knows, maybe we'll be seeing it happen soon. I'm sure the pharmaceutical industry would jump at the chance to get a foot up on 'herbal' remedies.

[Orchid_Suspiria]

A few months ago when SWIM was going through very bad methadone/fentanyl withdrawal he went to the doctor to get some benzos or anything that would help.He got some tranxene and a sampler pack of rozerem to help with sleeplesness.Unfortunately it has no recreational effects at all,infact it has no noticeable effects other than you feel sleepy in a pretty natural feeling way,as if you were truly sleepy without the help of any drug.swim would have far rather had ambien but considering swim was there for a problem with drug addiction his doctor did not want to give him anything that could be addicting,well other than tranxene which is a benzodiazepine ofcourse.If one has insomnia rozerem is a pretty good thing.If one wants an enjoyable chemical experience it is completely useless.

[sono2351]

I was given a month's worth by my doctor. Unfortunately, I lost interest as soon as I saw that one of the possible side affects is impotency. When I contacted my doctor, he said that the effects were only temporary and were reversible, however this still was not comforting to me as, when I read the full write-up that comes with it, it indicated that the long term impotency affect had not been studied and therefore could not be confirmed either way, something to that affect. Anyone else have more specifics on this or that could shed some more light on this?

[Spinner]

I wish my damn insurance company would pay for the fucking things, so I could try them. I was prescribed some, but I'm not paying for them, and Medica still refuses to pay. GRRRR!!!