Complete List of Opioid Dosages

[MrJim]

Ok guys,


SWIM needs everyones help here. There are many great minds in here soSWIM can't wait for input. He gathered the following information from a variety of places and he needs verification and expansion. Think a dosage is Way off? How about another drug left off? How about ANY pertinant information for this list. A wise one said that compiling a list of opioid dosages is something that comes with great responsibility.


So - This is it - For educational use only
Opiates are a difficult substance to provide standard dose information about. People all have different natural tolerances to opioids, which can increase dramatically over the course of their personal usage. I have personally known people who went from a 100mg of heroin in a day to trying to catch a similar buzz off of 500mg a day within 4 or 5 months. I have heard of some people using up to 2.5 grams in a day of Heroin after long term addictions.

OPIUM (refined) - Oral dosages - 1/3 -1/2 gram. Note that opium dosages can vary because every opium has different quantities of active alkaloids in it. Oral is a more risky way to injest because you can't control the dosage as well as with smoking. 2 grams can easily be fatal. (Bogumil - from Opium basics).
-Smoking - A matchhead sized piece at a time. 0.1 gram. You can feel opium almost instantly when smoked so it is easier to find a safe dosage this way.

Morphine - For the non-opiate tolerant 10mg, orally should be enough to produce euphoria. Morphine is more bioavailable insufflated and rectally, and for these routes, 5 mg would be enough to start with. Morphine is the bar to which other opiates are measured in terms of relative strength For more info see Fantasian's post - http://www.drugs-forum.com/forum/sho...504#post159504

Codeine - For the non-opiate tolerated a 75-125mg dose should be good to start safely with this drug Insufflation is not advised since this drug usually comes with acetaminophen for most preparations. For more info see Fantasian's post - http://www.drugs-forum.com/forum/sho...504#post159504

Thebaine – Not really a recreational drug in this form –a stimulant which can cause nausea but does act on the opiod receptors (much less at mu receptors than morphine-like substances.

Heroin (diamorphine) - Rarely seen in pure form since it basically lives as a street drug –Pure heroin dosage for the non-opiate tolerated –5-10mg injected 5-20mg snorted or smoked.

Oxycodone - for the non-opiate tolerated a 10-15mg oral dose should be sufficient. Insufflated or rectal would be 5-10 mg.

Hydrocodone, - for the non-opiate tolerant 10-20mg first dose. Insufflation is not advised since this drug usually comes with acetaminophen for most preparations.

Dihydrocodiene - 60mg would be a safe starting dose for the non-tolerated. Insufflation is not advised since this drug usually comes with acetaminophen for most preparations.

Hydromorphone, for the non-tolerated 2mg orally would be a safe start. 1-2 mg insufflated.

Oxymorphone, 1 – 1.5 mg injection, 2 mg orally for a start dose.

Buprenorphine, - Mixed agonist-antagonist effects. For treatment of opioid addiction. Starting dosage is reflective of level of opioid addiction prior to treatment. "0.5-1mg sublingual or via nasal route are a safe starting point for a non-tolerant novice user. Subutex comes in 2 and 8mg tabs. Sensual effects only develop after about 20-30mins and last 24-48 hours" - Credit - Citizen Kane. For more info see Fantasian's post - http://www.drugs-forum.com/forum/sho...504#post159504

Etorphine, - Not for Human consumption – Too dangerous to measure microgram readings. A scale affected by as little as an air current in the room could cause a measurement dosage large enough to kill someone. 1mg given to a five-year old African elephant knocks it out.

Naloxone - A Opioid antagonist – not for use unless someone has overdosed. Do not play around with this unless you want to feel violently ill.

Nicomorphine – more or less equivalent dosages to morphine. 10-30 mg injected is used in the drug clinical trials with significant analgesic effect.

Methadone – Typically used for maintenance programs to wean people off of opiates therefore the starting dosage is reflective of the level of opioid addiction that the patient suffers. It comes in 5, 10 and 40mg tablets as well as an injectable suspension.

Meperidine (Demerol), 50 mg would be a safe dose for the non-opiate tolerated first dose in tablet form. Injections would be about 25mg.

Fentanyl - Normally packaged as a 3-day patch. For injections 0.05mg would be a safe start. 0.1mg smoked. 50-100 times more potent than morphine. For buccal ingestion via Actiq lollipops 100-200 mcg would work for someone with no tolerance.

Alfentanil – 200-500 micrograms is a typical injection. Short acting and potent it is a drug very similar to fentanyl.

Sufentanil – 50 microgram injections are used to treat pain. All of these Fentanyl sub-type drugs are extremely easy to overdose on and utmost caution should be used around them.

Remifentanil – Another of the Fentanyl group. It differs in that it is the first ultrashort acting potent opioid for strong pain relief in a short period of time. Dosage is 0.5-1.0 ug/kg.

Carfentanyl -Another one not for Human consumption. It has a relative potency of up to 10000 times that of Morphine. Used to sedate large animals.

Ketobemidone - Dosed similar to Morphine. Normally only available in Scandanavia (credit - Hitme2ice)

Propoxyphene - (Darvocet) - 120-160mg for the novice user. Insufflation is not advised since this drug usually comes with acetaminophen for most preparations.

Pentazocine – (Talwin) Often mixed with a opiate antagonist to prevent abuse. 50-100mg orally or 30mg IV is a typical dosage.

Phenazocine – This one has been discontinued in many countries. 3mg was a typical dose to cause the analgesic effects of about 20mg of Morphine.

Tramadol (Ultram)– 200mg sustained release tablets are a safe starting point. Due to the size of the pills and the binders in them, snorting is not advised, nor does it seem well-absorbed through this route. Very little recreational effects (disputable) but effective pain killer. For more info see Fantasian's post - http://www.drugs-forum.com/forum/sho...504#post159504

Loperamide – No recreational value – does not cross the blood-brain barrier. Acts on the opioid receptors of the gastrointestinal tract. 2mg relieves diarrhea.

Always take less of a drug if one is naïve to it. It is better to learn what is not strong enough for you than what is too strong.

Reputation Comments on this post:

	Very good post! Excellent compelation of the recommended doses of many opiods. He has been responding to peoples posts ...
	Great post on various opiates
	great info
	Excellent post. :)
	Good work!
	very helpful, thanks
	I can't believe I didn't give you karma for this already!
	this thread is amazingly awesome and should have a link in the header, though you need to edit your header a bit to fix ...
	Great list, this should come in handy for many SWIMmers
	Extremely helpful. Thanks.
	Nice work.
	Good info on opiate dose
	Good!
	great work, interesting and useful list
	great idea, good info
	Possibly the most informitive post I've ever seen
	great thread, very useful information
	Great post, SWIM is astounded that such a small amount of etorphine could knock out an elephant :O
	exellent info
	Good stuff bro, this'll be helpful to alot of us
	informative post, with clear dosage ranges. keep it up!
	A valuable compilation of dosage info. Quite good as a quick reference for opiates dosages.

[mynameisshaun]

Nice, , Very informative.

Good job

[neurochem]

oral morphine has poor biovailbility..... I read somewhere that only 40% of it is actually acive once past the stomach. Injectable morphine whether SubQ, IM, or IV (the latter two) will have dosage requirements similar to oral hydrocodone or oxycodone. so 50mg morph IM will have the same effects as 50mg hydrocodone PO.

[MORPHEUS IV]

Originally Posted by neurochem

oral morphine has poor biovailbility..... I read somewhere that only 40% of it is actually acive once past the stomach. Injectable morphine whether SubQ, IM, or IV (the latter two) will have dosage requirements similar to oral hydrocodone or oxycodone. so 50mg morph IM will have the same effects as 50mg hydrocodone PO.

You are correct about the 40% bioavailability of oraly taken Morphine, whether long acting or instant acting. However, one has to disagree with the 50MG Morphine Sulphate compared to 50MG of Oxy or Hydrocodone. One has been said that 50 MG of hydro or Oxycodone does almost nothing as far as getting rid of wiithdrawals for a person using 50 MG of Morphine in any of it's forms. One could say that this was supported by personal experience of a friend.

And as far as Fentanyl, it is said to be 50 times stronger, but you sure wouldn't know it by taking it.

[Daytona71]

Originally Posted by MORPHEUS IV

You are correct about the 40% bioavailability of oraly taken Morphine, whether long acting or instant acting. However, one has to disagree with the 50MG Morphine Sulphate compared to 50MG of Oxy or Hydrocodone. One has been said that 50 MG of hydro or Oxycodone does almost nothing as far as getting rid of wiithdrawals for a person using 50 MG of Morphine in any of it's forms. One could say that this was supported by personal experience of a friend.

And as far as Fentanyl, it is said to be 50 times stronger, but you sure wouldn't know it by taking it.

Eating a 10mg. patch at once is the only thing on this list that gives SWIM a warm and fuzzy. I have heard that 10mgs. at a dose is very high and could have been deadly if not for tolerance. Please correct me if the largest patch the 100mcg. one does not contain 10mgs.

[Be-Bop]

Indeed MrJim, opiate dosage IS a really difficult one..for those of us habituated to Morpheous's dream-juice, it is so easy to forget what a powerful drug you are fooling 'round with! SWIM generally has two IV doses /day, each one around .3g in terms of 'street' dope,(it has been as high as 2.5g/day, tho' it's hard to keep the sort of income required for that level of consumption going...)obiviously, this is the 'best' that SWIM can get, but he has no idea what the actual purity is?


I have heard of people who were using A HALFOUNCE of heroin a day!!!!!! I know it sounds really unbelievable..but this guy had done 8 years inside for the bank robberies that he was doing to supplement the dealing that he was doing to support his habit...plus bullshit artists generally have a never ending supply of 'stories', & this guy had only ONE, & the details of it NEVER changed in all the times he told it to me....


I know other people(again, a dealer) who used 5g/day of pure dope-they were importing it from Thailand in the late '70's & early '80's...but then i have seen people without a tolerance ODing on $10 worth...it is a drug wherein the tolerance of the individual varies incredibly from person to person, as a side-bar to this conversation..does anybody remember when Kurt Cobain died & the people whowere saying he had been 'murdered' used as 'evidence' that he had five times the lethal dose of heroin in his system? What is the lethal dose to someone who has a habit? Smells like conspiracy theorist bullshit to me!


It seems like the Opiate's have an almost infinite ability to, given the access to the dope, increase an individual's tolerance to the drug! I don't know if there is an 'end-point'..or you could just keep on going up & up....to infinity & beyond!


Be-Bop Edited by: Be-Bop

[icecrew]

i think once a person starts using too much thats when the big two
letters OD appear, i mean if u keep going up and up with ur tolarance
in my opinion a persons body can only handle so much thats why people
have to be carefull when raising their drug dosage

Reputation Comments on this post:

	Factually inaccurate. Opiate doses can be raised almost without limit. OD is far more likely in an opiate-naive person, ...
	But we all know that for big users, higher does mean you risk it if you get surprise high purity

[Be-Bop]

I'd have to disagree with you icecrew (with all respect), maybe with coke, meth et al..yeah, i'd agree...but i have never, ever known a heroin user, who, is using a lot, to od & die...not from heroin anyway...


I've known quite a few people who HAD big habits, & then have tried to stop..& made it a week, or two, or more.....then (usually) get drunk, decide that they need a 'reward', or something for their 'good work' (or whatever little fucking demon is yakking away at the back of their brain..), score, & forget that their tolerance has dropped, shoot..& 10-20min later..they are DEAD!


I've also known junkies (active) who have been out of it on pills, or pills & alcohol. or just alcohol..who have died..but i have never known one user who has died from heroin alone! There has always been a 'break', or some other downer in their system.


This doesn't even address all the recreational users that i have known who have died...but whenever a junky friend of mine is trying to stop..i ALWAYS try & remind them that, IF they DO USE, just to remember that their tolerance will be down, & NOT to do it when they are drunk, or pilled...even tell them, if they have decided to do it..to come over to my place, where i can watch them, & won't pass judgement at their failure..tho', it's a sticky one..coz you don't want to encourage someone to fail..but it seems like it is shame that makes people, when they DO break..to do it by themselves..coz they don't want any of the people-who think they are 'doing so well', to know! & it only takes 5-20min for someone to go from ALIVE to DEAD....& then they are GONE..forever..it's always so fucking sad...fuck...


Be-Bop.

Reputation Comments on this post:

A very honest, heart-felt, poignant and obviously personally painful to Be-Bop to write. Shows great love though, and ex...

[samuraigecko]

Originally Posted by Be-Bop

I'd have to disagree with you icecrew (with all respect), maybe with coke, meth et al..yeah, i'd agree...but i have never, ever known a heroin user, who, is using a lot, to od & die...not from heroin anyway...


I've known quite a few people who HAD big habits, & then have tried to stop..& made it a week, or two, or more.....then (usually) get drunk, decide that they need a 'reward', or something for their 'good work' (or whatever little fucking demon is yakking away at the back of their brain..), score, & forget that their tolerance has dropped, shoot..& 10-20min later..they are DEAD!


I've also known junkies (active) who have been out of it on pills, or pills & alcohol. or just alcohol..who have died..but i have never known one user who has died from heroin alone! There has always been a 'break', or some other downer in their system.


This doesn't even address all the recreational users that i have known who have died...but whenever a junky friend of mine is trying to stop..i ALWAYS try & remind them that, IF they DO USE, just to remember that their tolerance will be down, & NOT to do it when they are drunk, or pilled...even tell them, if they have decided to do it..to come over to my place, where i can watch them, & won't pass judgement at their failure..tho', it's a sticky one..coz you don't want to encourage someone to fail..but it seems like it is shame that makes people, when they DO break..to do it by themselves..coz they don't want any of the people-who think they are 'doing so well', to know! & it only takes 5-20min for someone to go from ALIVE to DEAD....& then they are GONE..forever..it's always so fucking sad...fuck...


Be-Bop.

One is extremely correct in those theories in Opiate dosage.

SWIM also knows that alcohol and Opiates can (and DO very often) cause OD even when the dosage is within the users normal hit.

It is also very true that other OD's happen when one is rewarding ones self after a "break" as you call it, they think that their normal dosage is fine when in actual fact the bodies tolerance for opiates drops very quickly once one makes the choice to stop.

The basis of what one may be saying here is . . .

Opiates (especially especially "designer" purified opiates such as H, M and Oxy's etc) DO NOT mix well in ones system with alcohol and can present danger and even likelihood of fatality in some cases.

Tolerance for opiates in ones body declines quickly after one has given it away so the potential for OD is higher in people wishing to "reward" themselves for a job well done with another hit of their old usual dosage.

There were a lot of OD's in ones country because after the war in Afghanistan commenced the H got stronger on the streets, very strange since there was also a corresponding significant MILITARY presence in Afghanistan at this time. (One may even come to believe that perhaps our military funds itself at the cost of its home countries civilians).

Ones advice for anyone experimenting with Opiate based drugs is to be careful, research ones knowledge, its better to take too little than too take too much and end up with your friends visiting you, not at home, but in a graveyard with flowers.

Cheers and be safe.

[sands of time]

There is a point in which the level of opiates in the system can be toxic to the body, even if there is a massive tolerance. There is an end point, so be careful and don't let the habbit get out of control.

[Be-Bop]

Thanks for the concern Sands of Time, but believe me, my finances constrict my using to a level that is a long way from THAT point!!! Actually, it's not even the finance thing..i have used for long enough to realise that i'm NEVER going to recapture that beautiful 'rush' of those first few times!! My using is more about being 'even',& 'happy'...whenever my using has REALLY ESCALATED, & i have been using, say, 4-5 times/day..i don't enjoy it as much!


I think part of the 'pleasure' of using is to space out the tastes..so that you start to feel that 'need', & then the fulfillment of that need. In fact the 'best' tastes are the ones where you are SICK, & then feel the relief of that sickness..not that i ever wait that long..unless i am forced to!!!!


Be-Bop

Reputation Comments on this post:

for all your excellent contributions over time

[UNIBLACK810]

Originally Posted by Be-Bop

Thanks for the concern Sands of Time, but believe me, my finances constrict my using to a level that is a long way from THAT point!!! Actually, it's not even the finance thing..i have used for long enough to realise that i'm NEVER going to recapture that beautiful 'rush' of those first few times!! My using is more about being 'even',& 'happy'...whenever my using has REALLY ESCALATED, & i have been using, say, 4-5 times/day..i don't enjoy it as much!


I think part of the 'pleasure' of using is to space out the tastes..so that you start to feel that 'need', & then the fulfillment of that need. In fact the 'best' tastes are the ones where you are SICK, & then feel the relief of that sickness..not that i ever wait that long..unless i am forced to!!!!


Be-Bop

I definetly have to agree. For SWIM the best part was going to the spot sick, than copping your bag sitting, somewhere to do it light a ciggarette and feel the ill start to fade away. Dont get me wrong SWIM hates to be dopesick. But just the high seems much better and more intense when your sick. Just SWIM two cents.

[Adultswimmer]

SWIM read an article in the New England Journal of Medicine a few years ago. It was in regards to the role ethnicity plays in tolerance. Sorry that SWIM can't remember the whole article but does remember some.

Native Americans were at the highest level of tolerance on the graph
Asians were at the very bottom
European whites and African Americans were close to the middle with African Americans being slightly lower than whites
Latin Americans were slightly higher than whites on the graph

Some other considerations are gender and weight, along with bi-racial or a mixture of ethnicities. For example, SWIM is 1/2 Native American, 1/4 French, and 1/4 Welsh, so would considered to be half way between the middle and top of the graph. SWIM has personally found that she would be closer to the top in reality.

There are current pharmacogenomics research to study the implications of drug responsive genetic variations, where significant differences have been found based upon race, ethnicity, and gender.

Just keep it in mind that your ethnic background could have a role in your tolerance as well.

[Alfa]

When you review all these dosages, can you find any dosage which might be dangerous on a first encounter with the drug? This is essential with dosage advise.

Reputation Comments on this post:

Yes, this thread would do well to err on the side of caution, a disappointed veteran is better than a blue newbie

[MORPHEUS IV]

Originally Posted by Alfa

When you review all these dosages, can you find any dosage which might be dangerous on a first encounter with the drug? This is essential with dosage advise.

YES, I found one that concerns me................the 4 MG of hydromorphone (Dilaudid) for the first time user. I think that is too much, especially considering that 4 MG is the highest dose there is in pill form. I would say that 2 MG at a time is PLENTY for the novice user. What do you think?

[genaro]

What about OPIUM dosages (for a individual with no opiate tolerance) ?

Raw opium oral dose ?
Raw opium smoked dose ?

Refined opium oral dose ?
Refined opium smoked dose ?

[MrJim]

Originally Posted by genaro

What about OPIUM dosages (for a individual with no opiate tolerance) ?

Raw opium oral dose ?
Raw opium smoked dose ?

Refined opium oral dose ?
Refined opium smoked dose ?

Morphine content varies too much in Opium. That's the problem with giving accurate dosing info. Maybe someone knows a way to phrase opium dosing in a safe way?

[MrJim]

Originally Posted by MORPHEUS IV

YES, I found one that concerns me................the 4 MG of hydromorphone (Dilaudid) for the first time user. I think that is too much, especially considering that 4 MG is the highest dose there is in pill form. I would say that 2 MG at a time is PLENTY for the novice user. What do you think?

Good point - Changed.

[JiggaMan]

Actually they make hydromorphone pills in 2's, 4's, and 8's. I dont think Hydromorphone is a good drug to try for a first time user. Take a lortab or something

[Sickpeache]

Methadone comes in tablets like you stated. I didnt know it came in injectable substance. You may want to mention that it also comes in a liquid that is taken orally. And obviously, as with other forms, dosage can vary GREATLY depending on the users tolerance and how much they have weaned off of the substance (From 1 mg to infinity!). Swim started at a methadone clinic 5 years ago, taking 150mg daily. Which apparently is ALOT. And swim knew other people a the clinic taking much more. She is down to 30 mg daily now. Swim knew people at the clinic taking much more than her beginning dose and people going everyday just to take 1mg.

[raven3davis]

Originally Posted by MORPHEUS IV

YES, I found one that concerns me................the 4 MG of hydromorphone (Dilaudid) for the first time user. I think that is too much, especially considering that 4 MG is the highest dose there is in pill form. I would say that 2 MG at a time is PLENTY for the novice user. What do you think?

SWIM definitely agrees that you should start low but SWIM and all his friends started with 8mg and they were fine. SWIM did 16mg within 30 minutes for his first time and was okay. He barely ever does opiates either. Its best to be on the safe side though. Are you sure that hydromorphone does not come in 8mg? SWIM is 99% positive it does because he took an 8mg pill up the nose. He even saw the bottle. Hydromorphone substitute for dilaudid (8mg).

[Hydro9177]

Originally Posted by MORPHEUS IV

YES, I found one that concerns me................the 4 MG of hydromorphone (Dilaudid) for the first time user. I think that is too much, especially considering that 4 MG is the highest dose there is in pill form. I would say that 2 MG at a time is PLENTY for the novice user. What do you think?

No, they make 8mg Dilaudids, too!

[Jeff Woad]

I agree with all from the list that I can speak of, never tried any of the *.dones or *.phones. Not including methadone- Which is seen more often as a liquid. Someone with no tollerance would take no more than 15-20 ml (1mg/1ml)

I STRONGLY ADVISE ANYONE WHO HAS COME THIS FAR THROUGH THEIR LIFE WITHOUT TRYING OPIATES/OPIOIDS NOT TO!

EVERY HEROIN ADDICT IN THE WORLD THOUGHT THEY WOULD BE THE ONE TO NOT BECOME ADDICTED AND BEAT THE SYSTEM.

IF YOU MUST TRY OPIATES/OIDS, ONCE A MONTH MAX.

Reputation Comments on this post:

Honest and caring post.

[Handle]

deleted

[icecrew]

yeah, once u start and realize how "good" it makes you feel its the hardest thing in the world to stop because that feeling is just so damn good. stoping doing dope is like the same thing as getting devorced with ur loving wife = ] that sucks ur dingaling every night n what not. but in the other hand its the same wife that wants to cut off ur balls while ur sleep hmm i dunno i guess theres alota ways u could put how hard it is ..me im using as much as i can before im off to jail on jan 10 for like atleast 6-9 month..thats when my stoping will occur BTW .steet dope sucks = [

Reputation Comments on this post:

Nice analogy.