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Concerta & Ritalin About Methylphenidate.

 
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  #1  
Old 13-03-2010, 21:14
john.fabrim john.fabrim is offline
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How to potentiate methylphenidate (Ritalin/Concerta)?

The purpose of this thread is to collect information about how to potentiate methylphenidate to increase the therapeutic effects by combining the drug with legal substances/methods. The purpose is not to find out how to induce euphoria or similar.

The aim is to help SWIM and SWIY who believe they should have a higher dose of the drug than the doctors want to prescribe.

Hopefully, SWIY will inform about which substances/methods do potentiate methylphenidate and to what degree they do this.

Other threads have already discussed this subject, and the substances listed below have been suggested. SWIM hopes that this thread will "continue" the discussion to generate even more information.

These substances/methods are suggested in other threads:
L-tyrosine
Grapefruit juice
Caffeine
Magnesium
Sublingual administration (Placing the pill under the tongue.)
Insufflated administration (Inhaling the drug through the nose. Note that SWIM doesn't know if it is needed to process/extract the drug before inhaling it.)

Earlier threads:
http://www.drugs-forum.com/forum/sho...d.php?t=106996
http://www.drugs-forum.com/forum/showthread.php?t=21690
  #2  
Old 14-03-2010, 16:14
harres harres is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

Apparently the amino acid "L-methionine" potentiates methylphenidate. Apparently Zinc does so too. Something alkaline in the stomach may help.

If you're looking for good bioavailability, you may also consider the holy route. best for this is Ritalin (R) (not Equasym), disolved in 3ml water, inserted 2cm up with a syringe without needle. if swiy is male, swiy will not feel gay. incidently, if they made methylphenidate in enema form, that would be easier.

Sublingual is good too. Insufflating is uncomfortable, burns etc. up the holy is obviously not practical either for constant therapeutic use.

if swiy are using concerta, swiy does not have all these option, unless swiy goes through the trouble of scraping, peeling and cutting.

I highly doubt Grapefruit juice will help. Vit C and citrus potentiates secretion via kidney.
  #3  
Old 17-03-2010, 11:46
Lukeoca Lukeoca is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

L-theanine improves the theraputic effect for SWIM. It reduces the edgy feeling and smooths over his concentration. This has benefits for all occasions on MPH, whether it is doing project work, socialising or relaxing.

DL-Phenylalanine - amino acid similar to L-tyrosine

Macuna Puriens - apparently contains L-dopa which is the precursor to dopamine

Getting plenty of sleep improves effectiveness (this makes a big difference for SWIM)

Keeping hydrated and eating well also improves the effectiveness

Last edited by Lukeoca; 17-03-2010 at 11:52.
  #4  
Old 17-03-2010, 15:03
john.fabrim john.fabrim is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

Harres and Lukeoca, SWIM thanks SWIY for the valuable information.

Does any of the substances mentioned have significantly higher potentiating effect than the others?
  #5  
Old 21-03-2010, 22:48
emeth8 emeth8 is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

One way is to add Stratera to your dosage of methylphenidate it should help lengthen the time between dosing.

emeth8 added 97 Minutes and 56 Seconds later...

Also found that drinking milk can lengthen the effectiveness of your dosage.

emeth8 added 223 Minutes and 48 Seconds later...

If your looking to potentiate ritalin with caffeine try SPIKE energy shots they have 325 mg. of caffeine.

Last edited by emeth8; 21-03-2010 at 22:48. Reason: Automerged Doublepost
  #6  
Old 21-03-2010, 22:54
freedomf freedomf is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

swim finds that nestea or icetea helps better than cofee
  #7  
Old 21-03-2010, 23:46
Ancap Ancap is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

It might be a good idea to define the effects of these "potentiators" a little more clearly. For example, some drugs, supplements, or liquids will increase the duration of the effects. Others will increase intensity. Some might quality of the positive mood/focus effects while extending the duration of physical effects like heart rate, blood pressure, and jitters.

Also, some discussion of WHY these chemicals work would be important. There are actually several potentially dangerous combinations listed above, and SWIM would advise ANY methylphenidate user to exercise extreme caution when supplementing their dose with anything.
  #8  
Old 22-03-2010, 00:04
freedomf freedomf is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

ok a no combo is methylphenidate with heroin because methylphenidate is so strong that you have problem to understand heroin and an overdose is sure
  #9  
Old 22-03-2010, 00:23
Ancap Ancap is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

Ok, yeah... Heroin isn't a good potentiator for MPH... (?)...

But here's what SWIM meant in the above post. Of the things listed so far:

L-tyrosine- non-essential amino acid precursor to dopamine that easily crosses the blood/brain barrier. Dopamine is depleted with use of methylphenidate, so preloading and postloading the body with dopamine can ether extend the duration of a "binge" (preloading) or can help an individual recover afterward (postloading). NOTE: MPH binge NOT advised.

Grapefruit juice– for some reason blocks an enzyme that breaks down methylphenidate in the stomach. This allows more of the drug to pass through the digestive system and into the blood stream. (Increased "bioavailability")

Caffeine– be careful. Some people are very sensitive to this combination. The above mentioned [brand name] energy supplement combined with, say, 20mg of MPH could cause serious tachycardia, blood pressure, and panic disorder problems in sensitive individuals.

Magnesium– decreases acidity of stomach, slowing the absorption of methylphenidate. Probably does NOT increase bioavailability, but will extend the duration of the dose. So, the user wouldn't get the full effect, but the dose would last longer.

Sublingual administration– can increase bioavailability by 5 to 20 percent. Totally depends on the individual body chemistry.

Insufflation– Can greatly increase bioavailability, rate of absorption and decrease time before peak effectiveness. Greatly shortens the effective duration. MUST be prepared differently. A crushed tablet should not be insufflated as there are a number of water insoluble components in the "binders" that will clog and irritate the sinuses.

Phenylalanine- can be toxic and causes brain damage in a small percent of the population. Is also fairly "speedy" by itself and can intensify the physical effects of a stimulant to the point that it is uncomfortable. Has been rumored to induce panic attacks when combined with large doses of methylphenidate.

Post Quality Evaluations:
Good summary and info.
  #10  
Old 22-03-2010, 15:19
john.fabrim john.fabrim is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

Ancap, swim certainly agrees that "It might be a good idea to define the effects of these "potentiators" a little more clearly". The fact that swiy thoroughly explained how the different potentiators work is great, thanks a lot swiy!

Swim has tried grapefruit juice and magnesium without noticing any differences. Swim has also tried caffeine but didn't notice any additional effect to what caffeine normally has. Swim only tried 100 mg of caffeine though. Of course, other people might get better effects than swim.
  #11  
Old 24-03-2010, 00:34
emeth8 emeth8 is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

swim tried l-tyrosine about 6000mg. and hasn't really noticed a difference
  #12  
Old 24-03-2010, 04:55
Ancap Ancap is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

Quote:
Originally Posted by emeth8 View Post
swim tried l-tyrosine about 6000mg. and hasn't really noticed a difference
As stated above– L-tyrosine is a dopamine precursor. It can be used to replenish the body's dopamine supply after a stimulant binge to counteract some of the effects of a crash.

If taken beforehand, it may increase the total amount of time that an individual can "binge" before the stimulant becomes ineffective.

When it comes to CNS stimulants, dopamine is a little like fuel in a car. Abusing methylphenidate is like driving really fast and hard. It will drain the tank faster, drastically reduce milage, and increase general "wear and tear." L-Tyrosine supplements can be used as a sort of back-up gas can to help keep you going when your engine stops in the middle of nowhere.

Ha! I just realized that methylphenidate and miles-per-hour and both abbreviated "MPH." So, yeah... more MPH = less fuel.
  #13  
Old 24-03-2010, 12:57
Lukeoca Lukeoca is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

I agree with your logic but since Methylphenidate is a reuptake inhibitor and not a releaser of dopamine, how could the dopamine be depleted? I thought perhaps the body would in some way temporarily reduce dopamine production due to the increased presence of dopamine between synapses while on Methylphenidate. Therore causing a dip in production once the MPH wears off before it starts producing again.

Either way, I think L-Tyrosine is useful, both to potentiate the effect of MPH but also lessen the crash at the end of the day. Perhaps it would be best taken mid-way through use of Methylphenidate, otherwise you wil go from MPH + Tyrosine to neither which may make the crash much worse. But as far as potentiation goes, l-tyrosine is one to try, but be careful as it may increase the side effects ofthe MPH you are taking. I.e if you already feel a bit wired while on your optimal dose of MPH, then l-tyrosine may push this over the edge which can defeat the purpose of potentiation causing palpitations, anxiety, jitteriness , you know the drill


On a side note - has anyone any information about methylphenidate as a dopamine releaser? As far as I was aware it is just a Dopamine, Norepinepherine reuptake inhibitor?

Lukeoca added 6 Minutes and 50 Seconds later...

Quote:
Originally Posted by emeth8 View Post
swim tried l-tyrosine about 6000mg. and hasn't really noticed a difference
That's a really high dose - I'm not sure there is a ceiling limit as to how much is effective. I have pills with 500mg and I notice an effect. Just remember to take them on an empty stomach (first thing in the morning is best, I hear)

Also there are certain other ways to aid absorption. In general after taking L-Tyrsine give yourself a couple of hours before consuimg any protien rich foods.
But I'm no expert, and my memory is holey. There is plenty of information around.
SWIM does feel effect of L-Tyrosine and Concerta with a 500mg dose, taken on empty stomach etc. Sometimes it can be quite hit and miss however.

Last edited by Lukeoca; 24-03-2010 at 12:57. Reason: Automerged Doublepost
  #14  
Old 24-03-2010, 18:37
Ancap Ancap is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

Sorry to use this as a source, but from Wikipedia:

"Methylphenidate exerts its therapeutic effects via blocking the reuptake of dopamine into nerve terminals (as well as stimulating the release of dopamine from dopamine nerve terminals) resulting in increased dopamine levels in the synapse."

Interestingly, wikipedia's sources also mention that methylphenidate increases the magnitude of dopamine release after a stimulus, increasing the salience of the stimulus.
  #15  
Old 28-03-2010, 09:09
cherrygolightly cherrygolightly is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

Has anyone heard anything on taking L-Tryptophan to help with come downs and tolerance?

Golightly's dad gave her a bottle that he didn't want. (Sleeping purposes and it didn't work) Her tolerance is out of control and magnesium, reset-ad (if you're not a dude don't touch it makes you grow a girl stash) and ampheta-restore didn't do anything
  #16  
Old 17-01-2011, 20:48
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

SWIM will add:

He's been on 30 then 60 mgs a day of Focalin XR for 6-7 months. It has almost no effect anymore, and what little perceivable amount it does lasts 1-2 hours at most.

SWIM took 4 days off. No difference. 6 days off. No difference. Antacids, no difference.

SWIM recently bought L-Tyrosine and has been taking 2000-4000 mgs a day. Along with every vitamin known to man. No difference.

Shit just doesn't work for him anymore. Wish there was a real potentiator.
  #17  
Old 17-01-2011, 21:00
ratatata ratatata is offline
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

my cat thinks maybe switching to a (assuming a doctor is giving him those focalin) different stimulant, perhaps adderall (if you tell them focalin isn't giving him any effect, the'd probably be happy to switch him over to adderall, at least for a while to reduce mph tolerance) might help

my cat incidentally just ate a grape fruit before he's about to take some mph. he can attest to the fact that, as far as actual effect is concerned (ignoring duration), my cat finds rectal--nasal--oral seems to be the order of roa's he's tried, and is abotu to try to sublingualy/nasally administer some mph to see how that works out

as far as potentiation my cat hasn't noticed any significant effect from grapefruit and caffeine doesn't seem to potentiate it as much as he experiences a stimulant effect from both and its just a little bit uncomfortable

my cat maybe should get some l-tyrosine, the crashes after a binge are the worst, and he's pretty down the next day
  #18  
Old 31-01-2011, 14:16
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

Some quick research on this topic shows that Selegiline will potentiate Ritalin in particular about about five times and Amphetamines three to four times.

An interesting thing about Selegiline with Ritalin is that it will potentiate the stimulant effect only half as much as the euphoric effect. It will also lengthen the high Incredibly. This is the case with Amphetamines too but not quite as much, the real combo is with Methylphenidate.

A Disney character told me that she takes 10mg Selegiline and 5mg MPH and produces a very clean, euphoric effect that lasts most of the day.
Use extreme caution, caffeine should be avoided and DO NOT underestimate the 5x potency!

Stimulant overdose is very easy to do, even 10-15mg can lead to hypothermia, agitation, disphoria and other negatives. Start slow, 3-5mg of Selegiline and 5mg MPH or AMP and work your way up. The more Selegiline the more potency.
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Old 03-04-2014, 00:09
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Re: How to potentiate methylphenidate (Ritalin/Concerta)?

I Have an ADHD (without hyperactivity) and i have a Concerta prescription. My daily dose is 63 mg. It has been 3 years since I started the medication and I must say that it is really helpfull. This morning, (2014/04/02) I took a bowl of cereal with milk and three glasses of milk. It was the first time (well I think) i have taken that much milk in a breakfast (there was nothing else to eat so you know) while I was on medication. So after eating (8:10 AM) I went to school and studied in the bus for my history test. I hate this class and I just can't study since I find it so boring, but this morning was different: It was sooooo interessing I just couldn't believe I was actually enjoying studying the school subject that I hate the most! I was looking at things in a total different way and I could remember everything I was reading! Then I arrived at the school, put my backpack into the locker blablabla and then I sat at a table with my friends, waiting for the bell to ring. (9:05 AM). Having a friend that loves history and politics, I started talking to him about it and I was really into it and we kept the conversation going for a while (I don't know anything about politics, but I could answer everything back without even thinking about it). As I was talking, I could feel a enormous boost of energy increasing, which I never experienced before. So then the bell rang, and one hour and a half later the class was over.the test was super easy! Everyone thought it was hard as hell, and I did not even study until this morning! Anyway, later, (12:55PM) I played ping-pong with my friends after eating (I'm really bad at ping pong and ping pong is the same as table tennis), but this time I was pretty damn good! Skiping to 1:30PM, I was in Math, and we started a new subject. Usually I just don't listen what the teacher says and read with the manual before the exams. I predicted what the new subject would be, and I was right haha. I answered every (or almost) of his questions even if he never spoke about it! People were staring at me like what the hell is up with that kid how does he know that!? Anyway in the day I was extremely speeded but it wasn't bad at all! I was really happy and everything was just so easy! So As a conclusion, I think milk DOES potentiate methylphenidate effects without any apparent bad side effects. The high was as long as the other normal day's high but a lot more intense and effective! I will definetly try it again tomorrow and post the results online. Oh and the down wasn't there, like it just left me normal after the high. Anyway, I'm sorry for my sloppy english, i'm french. I know this was a big text but i tried to put as much details as I could and bring back milk into the game, even if milk looks like the weakest potentiator out there.

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