GHB and opiates

[Perromaldido]

Is there any medical evidence that G agonize some opiate rsceptors? I know it's been used to treat H WDs. While on G I tapered down on methadone significantly in a JUST a few days. That's nearly damn impossible. The only factor that could have made it possible is G.I'm down to my last10 mils a day. Tomorrow I'll go for five, keep another five with me should thingsgo bad...Once G was discontinued no opiate WD took over. Anyone has a clue?


Perro

[BrandonAA]

count your lucky stars

[Perromaldido]

You're prolly right, Brandon. All I could find is these few lines:
<DIV ="pageer">Opiod</DIV>
<DIV ="pageer"></DIV>
<DIV ="pageer">GHB has been found to increase brain levels of the endogenous opiods, dynorphin and beta-endorphin (25). The opiod receptor antagonist, nalaxone, significantly reduces the metabolic and pharmacological effects of GHB (including dopaminergic) -- leading some to suggest that the opiod system modulates its activity on dopamine (26). In addition, GHB induced EEG changes are mimicked by administration of morphine and beta-endorphin (26). As with serotonin, GHB induced sedating and antidepressant/euphoric effects could be be mediated by the opiod system. </DIV>
<DIV ="pageer"></DIV>
<DIV ="pageer">Perro</DIV>
<DIV ="pageer"></DIV>
<DIV ="pageer">25. Lason W, Przewlocka B, Przewlocki R Life Sci The effect of gamma-hydroxybutyrate and anticonvulsants o­n opioid peptide content in the rat brain. 1983;33 Suppl 1:599-602

26. Snead OC, Bearden LJ Neurology Naloxone overcomes the dopaminergic, EEG, and behavioral effects of gamma-hydroxybutyrate. 1980 Aug;30(8):832-8
</DIV>


Edited by: Perromaldido

[Perromaldido]

5 with some minor disconfort...


Check this


http://www.mayoclinicproceedings.com...e.asp?AID=961& UID=





Perro

[Perromaldido]

And this...





http://groups.google.com/group/alt.d...rowse_frm/thre ad/712d64f9d4569bb6/599accc24ee0bcd2?q=%27%27withdrawal+dura tion%27%27&rnum=3#599accc24ee0bcd2


Perro

[ContnWantn]

this sounds promising... for wd's... from opiates forsure...


let us all know if anyone gives it a go...