Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News
Go Back   Drugs Forum > DRUG-FORUMS > Various drugs not covered by other forums > Antipsychotics
Mark Forums Read
Register Tags

Notices

 
Thread Tools
  #1  
Old 01-01-2010, 20:07
OrbitalSPIN OrbitalSPIN is offline
Account Awaiting Email Confirmation.
 
Join Date: 16-08-2009
33 y/o Male from United States
Posts: 39
OrbitalSPIN is learning how to become a psychonaut.
Points: 66, Level: 1 Points: 66, Level: 1 Points: 66, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Loxapine : More of an atypical or typical antipsychotic ?

As a hobbie and for pesonal reasons SWIM researches Pharmaceuticals. One in particular has caught SWIMs attention. It is an antipsychotic called Loxapine, Its a member of the Dibenzoxazepine class, its chemical structure is 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f] [1,4]oxazepine. Its structurally related to Clozapine and it has antidepressant effects. When Loxapine is metabolized in the body some of it is metabolized by N-demethylation to Amoxapine, a tricyclic antidepressant. Its been argued amoung many Pharmaceutical researchers and some Doctors that Loxapine behaves more like an atypical antipsychotic than a typical antipsychotic. SWIM agrees with this notion of Loxapine being an atypical and thinks that this medication should be given a second look to treat some Psychiatric problems. Question#1: Although Loxapine is classified as a typical antipsychotic does a FOAF think its more of an atypical antipsychotic ? Question#2: Does a FOAF think that this medication should be given a second look amoung Pharmaceutical researchers and Doctors ?

Post Quality Evaluations:
well stated question on loxapine
  #2  
Old 02-01-2010, 22:02
chibi curmudgeon Gold member chibi curmudgeon is offline
Gold Finger
 
Join Date: 26-11-2008
33 y/o Female from United States
Posts: 1,367
chibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPAC
Points: 2,404, Level: 7 Points: 2,404, Level: 7 Points: 2,404, Level: 7
Activity: 5.1% Activity: 5.1% Activity: 5.1%
Re: Loxapine : More of an atypical or typical antipsychotic ?

Loxapine kind of sucks. Based on the side effect profile, I'd consider it a typical AP, though iirc it's closer to clozapine than, say, haloperidol. It's possible I'm confusing it with something else, though.

My humble opinion is that clozapine isn't that bad, as long as one doesn't have a problem with weight gain or white blood cells, and I wouldn't consider it last-line therapy. But loxapine has all of the dyskinetic, NMS, hyperprolactin type crap going on, and I'd place it in the last resort category.

I don't think I've ever seen it prescribed, and in class it wasn't even brought up. Typical or not, it's one of the crappier APs.

Post Quality Evaluations:
accurate reply well put

Share this on:

Tags
antipsychotic comparison, loxapine

Thread Tools


» New Threads
I don't know what to do.
Last post by TiredHubby
0 Replies, 1 Views
Ways to hide/mask meth symptoms...
Last post by TweakerGirl
46 Replies, 100,353 Views
Boyfriend has turned psychotic...
Last post by OnTheStrength
2 Replies, 90 Views
Methadone (p.a.w.s) help :(
Last post by imhooks
1 Replies, 19 Views
Long time (prescription) Adderall...
Last post by OnTheStrength
3 Replies, 105 Views
Fake Xanax bars on the black...
Last post by Capo
5 Replies, 457 Views
Homemade enema and cleaning the...
Last post by ianzombie
5 Replies, 172 Views
Addicted to Loperamide-New Year,...
Last post by myrandomchaos
194 Replies, 11,578 Views
Loperamide slowly after trying...
Last post by myrandomchaos
66 Replies, 2,114 Views
Taking 3 x 1.5mg Klonopins
Last post by Capo
3 Replies, 133 Views
» New Wiki Articles
GHB
NET

Sitelinks: Information:

All times are GMT +1. The time now is 17:46.


Copyright: SIN Foundation 2003 - 2014, All rights reserved