Yohimbe bark extraction

[600538411]

SWIMwants to extract Yohimbe from the powdered bark via a solvent extraction then form the "HCl" salt, anyone know if this is possible? An ethnobotanical horticulturalist told SWIM that it is hard to do... Any ideas?

[daeron]

hmm preparing yourself for some orgy action there i see.....bad..bad..bad chief bikini inspector


i dont see why would it be so hard to do...get that horticulturo..well i cant spell today;to find for you a comprehencive alkaloid listing of the bark so you know what youre working with.also check in what form it is(salt/freebase)


here is a start:

It(edit:yohimbine.hcl ??) is a yellowish crystalline powder; melting point 270 C; insoluble in water and ether; soluble in alcohol, acetone; freely soluble in acetic acid, chloroform......blahblah....Yohimbine(edit what .hcl salt,freebase,fucking what youignorant fucks?)is a white crystalline powder; odorless; sparingly soluble in water; soluble in alcohol and chloroform

so you could start w a MeOH/EtOH extraction to get the crude extract than try a/b.hmm maybe a steam dist before and after a/b but youll have to check the salt/freebase volatility first(ie to see if it will come over at all).


happy hunting


PS wait-dont tell me! the next post is "Bulk Viagra One Pot Synth For Noobs"


PPS more info:

Yohimbine Hydrochloride:Orthorhombic plates,Prisms from alcohol...Yohimbine: Orthorhombic needles(edit:useful for recryst. and cryst identification)...blahblah...Yohimbine Hydrochloride: Soluble 1 in 120 of water and 1 in 400 of alcohol...Yohimbine:Very slightly soluble in water,Soluble in ethanol and chloroform,Sparingly soluble in ether(edit:i guess theyare talking about grams)

Edited by: daeron

[daeron]

Originally Posted by some idiot who prefers more to solve chem puzzles than to actually do some work around here...

so you could start w a MeOH/EtOH extraction to get the crude extract

that is if youre starting w a freebase in the plant


some more stuff to think about-the stability of the molecule?meaning how does it react in diffrent pH environments,what pH sol of acid/base can you use,etc


also concerning the.hcl salt(which if is true means that what ive said is complete bullshit)whichsome more info,different source:

Originally Posted by some deutch dude

schwer löslich in Wasser (1 Teil Y.-HCl in ca. 100 Teilen W.)


löslich in siedendem Wasser (1 Teil Y.-HCl in ca. 20 Teilen siedendem W.)


schwer löslich in Ethanol 96% (1 Teil Y.-HCl in ca. 500 Teilen Ethanol)


schwer löslich in Methanol


praktisch unlöslich in Diethylether

and will you stop playing w my curiosity,i havesome work to dohere yknowEdited by: daeron

[Muirner]

I'd love to know how come your going to extract it? It could be a funny joke to slip that into your boys drink or something one night haha. Anyways, if u need an extract take a viagra, calias (sp), and talk to "Bob" he'll make youa happy camper.


Muirner

[600538411]

Originally Posted by daeron

check in what form it is(salt/freebase)

If comes in the freebase alkaloid form, this way clarified by the horticulturalist themselves....

Originally Posted by daeron

PS wait-dont tell me! the next post is "Bulk Viagra One Pot Synth For Noobs"

How did you guess you funny bastard, lol... No SWIM has full erectile function but they were more desiring it for it's "Fat Mobilization" properties... It is commonly used in "stacks" by bodybuilders (other common actives stacked are ephedrine, caffiene and clenbuterol)

Originally Posted by Muirner

Anyways, if u need an extract take a viagra, calias (sp)

Hmmm interesting, SWIM actually had no interest in this until now... They were just reading up on it though and seen the active in the "Calias Species" is Tadalafil;

Originally Posted by Internet source

Tadalafil is an oral drug that is used to treatimpotence (the inability to attain or maintain a penile erection.). It is a phosphodiesterase inhibitor that is similar to sildenafil (Viagra) and vardenafil (Levitra).


Penile erection is caused by the engorgement of the penis with blood. This engorgement occurs when the blood vessels delivering blood to the penis increase in size and increase the delivery of blood to the penis. At the same time, the blood vessels carrying blood away from the penis decrease in size and decrease the removal of blood from the penis. Sexual stimulation that leads to the engorgement and erection causes the production and release of nitric oxide in the penis. Nitric oxide then activates the enzyme, guanylate cyclase to produce cyclic guanosine monophosphate (cGMP). The cGMP is primarily responsible for increasing and decreasing the size of the blood vessels carrying blood to and from the penis, respectively. Tadalafil prevents an enzyme called phosphodiesterase-5 from destroying cGMP so that cGMP persists longer. The longer cGMP persists, the more prolonged the engorgement of the penis.

Interesting stuff... SWIM is actually interested in stemming into the chemistry of drugs of a different nature specifically Steroids and Thermogenic Stacks....Erectile disfunctionactually runs hand in hand with some steroid use(whenone experiences "deca dick" for example)


Hmm yes all very interesting...


On the Yohimbe thing... SWIM was told the most suitable solvent for extraction of the Yohimbe freebase was water which then leaves SWIM wondering howSWIM would go about forming the salt then... Edited by: 600538411

[daeron]

actually thats a quite interesting article.....and yeah swim once thought of looking into viagra synths.actually one bee that he knows did this,but its still kinda illegal,because you have to have a license for production.yohimbe legal situation on the other hand may be different...<?:namespace prefix = o ns = "urnchemas-microsoft-comfficeffice" />

SWIM was told the most suitable solvent for extraction of the Yohimbe freebase was water which then leaves SWIM wondering howSWIM would go about forming the salt then

you have to first check the stability(in what pH ranges it is stabile) of the molecule,or you can just gas the water/freebase solution w hcl,untill pH of ~7,the hcl salt will precipitate but what else will too?ive read that there are &gt;31 different alkaloids in the bark...than again swi# can use the precipitiate(sp,lol) as a yohimbe extract.it would have the same effect me thinks.

[600538411]

Yes SWIM too has read that the profile of Yohimbe bark has components that actually counteract the positive effects... SWIM is really not that phased with whatother alkaloids they pull across more so just are concerned with being able to accurately measure the amount of alkaloid being consumed....


SWIM is totally not convinced in gassing Yohimbe as HCl salt in water as SWID themselves quoted that Yohimbe HCl itself ishighly soluble in water... SWIM thinks this is where the problem begins... hmmm

[daeron]

well .hcl is only slightly soluble in water(1 part in 100 parts if we believe that german source) so a part of it would precipitate and a part would dissolve.so you just have 2 different phases you have to clean up.get the precipitate(and by analyzing the alkaloid,to be more precise the amine content in yohimbe you will have some idea on what had precipitated besides y.hcl).same w the water solution,evap etc..<?:namespace prefix = o ns = "urnchemas-microsoft-comfficeffice" />


now that i think about it--its better that you extr w EtOH/MeOH the freebase and than gas it since .hcl is very insoluble in alc

[600538411]

Yeah... The problem that SWIM can foresee and that they really did not convey in the last message is that the small quantity of alkaloid that is going to be liberated relative to the amount of solvent that will be needed to extract will likely cause the actives to be completely soluble at 1:100 even...


Hmm SWIM is thinking they will just fuck around with it and see what they can come up with and then post again...Edited by: 600538411