Saving money through potentiation of opiates

[allyourbase]

the easiest fashion of potentiating your opiates is through time potentiation with antacids, this of course only works with oral users. you can easily squeeze another 4 hours of high out of 2 medium strength tums taken with your dose.


now a more tricky potentiation is with grapefruit juice. you should only take about 2/3rds of your average dose when you do this. drink the juice one full half hour prior to dosing, then eat some antacids to nuetralize the citric acid's raising of your stomach PH. this affects both the time and intensity of the experience. particularly with dihydromorphinones.


save your dope, but dont sacrifice the high!

Reputation Comments on this post:

	I've seen you do some good posts.
	tums definitly help strength and duration!!
	Brilliant post, though don't forget about ol' Tagamet :)

[daveman]

hm very interesting, so would this work with snorting too? as some of it goes into your throat?

[Zandorf]

i think grapefruit juice would work with snorting since i beleive your
liver is still involved in metabolizing things which are snorted. i
don't beleive the antacids would have much effect on insufflated
opiates although i could be wrong.<!--
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[Beltane]

Sorry, I don't know what dihydromorphinones are. I searched and found a couple references to them, both by allyourbase</span>,
but I still don't know what they are. Will grapefruit juice and
tums make a vicodin nite better/longer? And what are
dihydromorphinones?



Thanks-



- B

[allyourbase]

dihydromorphinones include but are not limited to:


hydrocodone


codeineone


hydrmorphone


oxycodone


oxymorphone


and yes, yes they will. with hydrocodone alone Im a 140 mg a day user. potentiated with grapefruit juice I start nodding @ 40 mg. alone hydrocodone rarely lasts longer than 8 hours, with grapefruit juice it rarely lets you down before 12. the idea of grapefruit juice is to consume it before hand. it inhibits certain cytosomes in the liver. thereby allowing more of the product to pass through the liver and into your brain.Edited by: allyourbase

[Beltane]

So better for your liver as less acetominphen too, no?



- B

[McDiggy]

Grapefruit juice is an inhibitor of CYP3A4, which is a minor
metabolizer of hydrocodone and a major
metabolizer of acetaminophen. What this means is that degree to
which plasma concentrations of acetaminophen increase would be much
greater than the degree to which plasma levels of hydrocodone would
increase; thus the risk of liver toxicity is actually higher.



The OTC antihistimine chlorpheniramine is an inhibitor of CYP2D6 and
may help you accomplish what you seek. Warning though, high doses
would potentiate the "narcotic's constipation" that is often seen with
excessive opiod use.
Edited by: McDiggy

Reputation Comments on this post:

I wish all info. in this forum could be like this:informed, clear & sensible.

[Beltane]

Thanks to a cool doc, SWIM now has a big bottle of 10/325's. So now the questions:


How much grapefruit juice?


You want the real, pure stuff, right? How about the stuff that's a blend of pure and fake?


Why does the antacid thing work at all?


When using grapefruit, what if you want to re-dose? Say you do grapefruit (how much BTW?), then 1/2 hr. later you take 2 tums and 40mg hydro, then in a couple hours you want to take more hydro? Do you re-do the grapefruit thing and the tums or just eat more hydro or what?


Oh yeah, when you say "empty stomach," how strict is that? Say you've had some juice and maybe some tea or coffee, but no food. Could you take the grapefruit and go from there, or do you need to be really empty?


Thanks-


- B


EDIT: SWIM will likely try 3 10/325's w/ 2 tums to start. Maybe more later. Do you take more tums w/ each dose?Edited by: Beltane

[korky8097]

does the tums actually make it more intense or just last longer?
I think i will give this a shot friday. Do you need alot of
grapfruit juice? I was thinking of splitting a bottle (not sure
how many oz's) wiht a friend cuz of the taste.

[dr.gonzo]

Will orange juice work? I have heard that it also potentiates opiates, but I wasn't sure if it was true. I ask this because I am not the biggest grapefruit juice fan, but I always have some OJ lying around. Edited by: dr.gonzo

[Beltane]

SWIM drank about 20 oz. of grapefruit juice. Only planned to
drink 8 but it was so good. Experience lasted longer and it was
more intense at the usual dosage. Can't say as surely about
lasting longer as he did more, of course, after getting going.
Felt like it laster longer.



- B

[McDiggy]

Answers to the above:



No, orange juice won't work - it is not a potent inhibitor of those liver enzymes.



Don't drink gallons of grapefruit juice because it inhibits the
metabolism of the acetaminophen at a greater rate the the HCN.
That means liver toxicity will be realized faster.




Edited by: McDiggy

[Beltane]

SWIM has been messing around more with this and tho the results are not very scientific, they are indeed impressive.



He drinks 8 - 12 oz. grapefruit juice on an empty stomach. He
then takes 2 tums w/ 3 - 4 Norcos (10/325.) He'll usually take a
few more throughout the day, taking another tums or two with each
one. They seem to work harder and last longer than they ever did
in the past.



Thanks all-



- B

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[allyourbase]

I myself use minute maid ruby red grapefruit juice. its only about 100 ml of actual grapefruit juice in a 300 ml bottle (the rest is water and sugar). one bottle is plenty. the acetominophen need not be an issue. extract it if you must, or get some norco like the rest of the civilized world.

[korky8097]

im going to give this a go with snorted 4mg of dilaudid, I wish to get
the most out of it as possible. Ill probably split a bottle with
my friend. Ill get back to yall on friday.

[bigt]

tommorow on the way to work im stoping for tums and grapfruit juice thats all im saying... sounds like an offer i cant refuse

[Svperstar]

hmmm this is all very interesting, I will have to test it out tommorow night with ~50 mgs of Oxy.

I must say I am skeptical though, I have never heard about this anywhere else.

[Beltane]

So grapefruit juice 1/2 hr. before Norco I get.



Do you take the antacids WITH the Norco or a few minutes BEFORE to give them time to neutralize the acid in the stomach?



Thanks-



- B

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[Herbal Remedy]

i wonder does this work with other drugs other than just opiates like weed for instance? also would cranberry juice work too or does it have to be grapefruit juice (im not quite sure what about the grapefruit juice does the trick)... thanks for any help, peace...

[warandhate]

what potentiates morphine?

[bcStoner420]

Originally Posted by warandhate

what potentiates morphine?

Everything mentioned in the posts above, grapefruit juice dranken around 1 hour before time, and tums will both potentiate practically any opiates. I dont know why the tums thing works but im guessing it helps with absorption.

[warandhate]

All right SWIM took his 50mgKadian. Crushed it up took about 2/3s of it orally and then gave some to his friends. About 30minutes before i drank a glass of grapefruit juice and took 2 calcium TUMS. Felt the pill FAST and pretty intensely at first but then mellowed out real quick. I thought it was supposed to make it last longer. Still feel good, SWIM aint complainging. SWIM loves his drugs.

Still drinking the juice...

[bcStoner420]

When SWIM uses opiates, the same thing happens, it almost seems as if what he would think to be the comeup is the actual high itself.

[Forthesevenlakes]

after doing some research (and this is kind of an old thread) swim believes that grapefruit juice actually won't work for codeine. it somehow inhibits the metabolism of codeine to morphine, so that your high is less intense. somethin to look out for if swiy has t3's on hand. but for any other opiate/opioid, grapefruit juice and tums both work excellent. swim has also found that 30 mg of dxm can potentiate an opiate high by about 30%, in his rough estimation.

[Forthesevenlakes]

try taking two or three of the tums half an hour beforehand, and another two at the time of oxy ingestion, swiy wants the stomach to be as basic as possible (it'll still be mostly acidic, but the tums will raise the ph slightly, and taking some at the time of ingestion will ensure that the ph stays up while the oxy is absorbed).