SEROTONIN And MDMA

[TKD34L3R]

yeah i have fucked on x before.. ive dumped one and started peaking then bout 15 mins after i went n fucked.. doesnt bother me.. alhough speed does.. but thats a different story haha

[Nagognog2]

Okay folks, here is a notice for you all. Beginning this weekend, all posts dealing with the medical aspects of MDMA (XTC) regarding serotonin depletion/ HPPD will be undergoing a merger into this topic space. So if you have anything to contibute, please post it here. If you are looking for something you wrote or read before here, and it vanished - look here. We are trying to consolidate threads before hauling them into the new servers/software. Bear with us as we pull our hair out by the roots.


Thank you!

[Cure20]

Here is something interesting........
<H3>
<CENTER><BIG>Effect of 5-HT depletion by MDMA on hyperthermia
and Arc mRNA induction in rat brain</BIG>
by
Beveridge TJ, Mechan AO, Sprakes M, Pei Q,
Zetterstrom TS, Green AR, Elliott JM.
School of Pharmacy, De Montfort University,
LE1 9BH, Leicester, UK.
Psychopharmacology (Berl). 2004 Jan 20

ABSTRACT</CENTER></H3>
<BLOCKQUOTE><BIG><BIG>R</BIG></BIG>ATIONALE. 3,4-Methylenedioxymethamphetamine (MDMA) administration to rats produces an acute hyperthermic response and induces localised neuronal activation, which can be visualised via expression of immediate-early genes. The pharmacological and anatomical basis of these effects are unclear. At high doses, MDMA also causes selective neurotoxicity at serotonergic nerve terminals. OBJECTIVE. We investigated the effect of 5-hydroxytryptamine (5-HT) depletion on the acute hyperthermic response to MDMA and the pattern of neuronal excitation indicated by Arc (activity-regulated cytoskeleton associated gene) in naive rats and following administration of MDMA at a neurotoxic dose. METHODS. Expression of Arc mRNA was investigated by in situ hybridisation histochemistry using (35)S-labelled oligonucleotide probe. RESULTS. MDMA induced a significant hyperthermia together with increased Arc mRNA expression in cortical regions, caudate-putamen and CA1 hippocampus but not hypothalamus. At 21 days after a neurotoxic dose of MDMA, brain 5-HT and 5-HIAA levels were significantly reduced by 21-32%. In these animals, both the hyperthermic response and the pattern and extent of Arc mRNA expression induced by a subsequent dose of MDMA were unaltered. However, basal Arc expression was significantly increased in cortical regions and CA1 hippocampus. CONCLUSION. We conclude that the acute hyperthermic response induced by MDMA is not attenuated by moderate depletion of 5-HT, further questioning mediation via a serotonergic mechanism. Arc mRNA induction by MDMA exhibits highly localised expression, which is not altered following 5-HT depletion. However, following a neurotoxic dose of MDMA, basal expression of Arc is increased, particularly in cortex and CA1, suggesting that mechanisms underlying synaptic plasticity might also be modified.</BLOCKQUOTE>

[sonerer]

Supose this is worth posting again, it fits the category...

&gt;&gt; SLIDESHOW &lt;&lt;

[Cure20]

Wow, great slideshow, very interesting.

[baalchemist]

The high relies on a good supply of serotonin in the individual, if one
is quite serotonin depleted the high won't happen. So it may be the
person, not the grug in some cases where the high was minimal. That is
why proper nutrition needs to be in effect with a user, besides for the
obvious reasons. And that isnt a diet consisting of burger king &
jack in the box on a regular basis.

[neoken]

Well, i had just written a big article, but i had googling accident and
used this tab to spell check a word instead of a new one, which means
poof great original. so heres a summary

Pure MDMA damages your brain just like
regular if not more. You see when you take MDMA, what happens is it
releases a WHOLE lot if not all your serotonin which really limits how
high you can get on it. Regular use of MDMA can lead to damaging of the
nerve that receives the serotonin doesn't know how to handle it all and
you develop a so called "tollerance" to MDMA when in truth, your
receiving nerve of the serontonin is really damaged. Which can be fixed
with 1-8 months depend on how severe the damage or high your tolerance
is. As can you see its not really what they cut the pill with
most of the time that can really damage you (caffeine, DXM,
laxitives,ect...), although some do have other harmful substances in
them. It is just really how much MDMA you exposed yourself to at a
time. Remember the Higher you go, the more damage is probably being
done.

Don't me wrong, MDMA does do alot more then just that, it can cause
moments of less brain function and as you stand up from sitting/laying
down u can only wonder whats going on. Along with Temporary Hearing
loss of some frequencies (mainly highs) and some people have reported
one eye just being stuck or wondering around on its own.



even though PURE MDMA might seem to be more safe because its pure,
doesn't exactly mean its less harmful (take cocaine for example). If
you really want to avoid the bs in the pills that might be beneficial
or not i would try to always not do too much as it will keep your
tollerance low and you will have better rolls with less and save money.




Edited by: neoken

[billyloner]

have they actually proved its bad for you then? the last i heard the jury was still out... some studies suggest it permanently damages the brain, others suggest it is bullshit. with the lack of proper human research theyll never know for sure, because the vast majority of people who use e take other drugs too, especially weed... which kinda buggers any results.


there was a really good site i read once ages ago, the dea that explained a lot of the results in a pretty simple way. obviously its just some guy's interpretation of the results though... check out the section on neurotoxicity.

[OiledMandible]

^^^Thats all true, but I had ingested about 10 rolls within the past
week and rolled harder than I had ever in my life. I think this
stuff is simply powerful enough to overcome whatever serotonin defecit
you might have.



It came on strong, stayed strong for a long while, and very gradually
tapered off. I could not identify when I stopped rolling, unlike
regular XTC or molly. I was noticeably upbeat for about 2 days
after, and never felt down. I forgot to bring 5htp, so this was
without postloading.

[Nagognog2]

neoken: Can you cite your source(s) for this data about MDMA actually causing damage tosynapses due to serotonin depletion? I have heard this report, but it was from a US government source that had actually done the research using methamphetamine. Then said it was MDMA. Read: They outright rigged the results and lied. So please let us know your source for this information.


By the way - all posts relating to serotonin and MDMA will be moving this week to the SEROTONIN And MDMA thread as we condolidate things for the move to new servers and software.

[neoken]

I originally saw a video on it, i dont really remember what it was
called, but if i find it i will make the diagrams of it into a gif file
and post it or something...



edit: went googling

<a href="http://mdma.net/misc/ecstasy-mdma.html" target="_blank" target="_blank">What most worries scientists like Henry is the possibility that hundreds of
thousands of ecstasy users could be storing up mental health problems for the
future. Are they? George Ricaurte and Una McCann, a husband-and-wife team at
Johns Hopkins University in Baltimore, Maryland, have led the way in trying
to pinpoint the drug's longterm impact on the brain. And after nearly 15
years of research, they are convinced the drug can damage serotonin synapses
and nerve fibres. Indeed, they say, really persistent users even risk
succumbing to "pruning", in which the longer, thicker serotonin nerve fibres
in the brain wither and are replaced by a denser growth of spidery, shorter
ones. In short, swallow E week in week out and the fine structure of your
brain may never be the same again.</font></a>



<a href="http://www.garynull.com/Documents/Continuum/EForEcstasy.htm" target="_blank" target="_blank">One of the disturbing fears about ‘E’ is
that it may be causing mental dysfunction or permanent brain damage, often associated with
sustained abuse. It has also been suggested that it destroys nerve endings or synapses,
and in extreme cases could lead to irreparable brain damage.</a>



<a href="http://www.absoluteastronomy.com/encyclopedia/e/ec/ecstasy_drug.htm" target="_blank" target="_blank">Some
experiments indicate that continuous use at very high doses may
lead to the synaptic terminals of serotonin neurons being damaged. The
precise mechanism of this action is unknown,</a>



Wish i could remember the name of that video, i used to have it on my
pc, but i can't seem to find it. Quick and Dirty google might work
though. SWIM was also coming down from 2 blue dolphins after a 4 month
break from it. Special night for him since he was one of the 4 guys at
his friends Bisexual girl X party so he couldnt pass up the opportunity







Edited by: neoken

[cort]

yea that could defentially be true about the amount of supply of serotonin. my sertonin levil is pry bad because i have never used anything to help get the right nutrtition my brain needs. swims ate 130-150 pills in a year and a half. swim was thiknin abuot getting some 5htp sp? but i dont belive you can go to a store and buy it i could be wrong tho

[billyloner]

hasnt ricaurte's work pretty much been disregarded as biased though? i mean, he was funded by the dea in the 80s to show that mdma was harmful so they could outlaw it, and surprise surprise he found it. and wasnt it him who performed the experiments proving that "e" caused parkinsons or something, when theyd actually used methamphetamine...

[OiledMandible]

Ricuarte is a dumb lying bastard, pure and simple. At this point
my response to him claiming eating meat on an hourly basis leads to
immortality would be to become a vegetarian.