Purely for the advancement of my knowledge, do you have a source that says that other juices have the right ingredients? The basis for opiate
potentiation by drinking grapefruit juice has to do with the inhibition of the P450 enzyme which is an enzyme involved in the breakdown of opiates
, hence when it is inhibited, less opiates (or perhaps at a slower rate) are broken down, supposedly increasing bioavailability. From what I've heard, grapefruit is the only juice that has this property, but I could be mistaken.
nnizzle added 8 Minutes and 18 Seconds later...
Sorry.. I guess P450 isn't the enzyme, it's actually the CYP2D6 which is a member of a family of enzymes called Cytochrome P450
? I think that's right, but I am just reading articles about the "grapefruit juice effect" and explaining how I believe it works.
nnizzle added 2 Minutes and 53 Seconds later...
And the compounds which cause this inhibition are called furanocoumarins... and apparently orange juice does contain some of the same furanocoumarins as GFJ so perhaps it would actually work... I guess that's why paranoid_android said it was hard to say. Whoops.