That is quite interesting that 5mg chlordiazepoxide
somehow caused such a strong effect when combined with 400mg tramadol
, especially when the marmoset who ingested these drugs
also experimented and compared the results with 2mg clonazepam
Firstly, clonazepam in and of itself is not the best substance to enhance the effects of tramadol, however it is a great safety precaution as it is used as an anti-seizure medication. Clonazepam is sometimes prescribed along with tramadol when first initiating a patient to tramadol treatment for the sole reason of the risk of seizures with tramadol use.
is really irritated as she had a stash of chlordiazepoxide 25mg and 10mg buried in the back yard (not literally) for emergency last resort solution to benzo
withdrawl should that ever occur. However they seem to have disappearred and now there is no reason for SWIM to be able to obtain chlordiazepoxide again. SWIM's marmoset would have really liked to experiment with SWIYs results.
is very closely related to chlordiazepoxide and many other benzos
that have active metabolites are more or less similar in that the majority seem to be metabolized to nordiazepam. This holds true for quite a few of the 1,4-benzodiazepines and their similar active metabolites. The triazolo-benzodiazepines such as alprazolam
, ect typically do not have active metabolites. So it may be worth "very carefully given the previous posters experience" investigating other 1,4-benzodiazepines that are closely related to diazepam. While chlordiazepoxide obviously is a bit of an oddball with its atypical structure, its active metabolites are nordazepam (desmethyldiazepam), temazepam
, oxazepam, and some others... So while it is significantly different structurally than diazepam, it shares most of the same active metabolites as diazepam is metabolized via hydroxylation to temazepam which is metabolized to oxazepaam via N-demethylation. Diazepam is also metabolized into nordazepam (desmethyldiazepam) via N-demethylation. So the question SWIM is wondering is if it is the active metabolites which are responsible for such a pronounced effect at such a low dose or the chlordiazepoxide which is active for around 24 hours before it is metabolized to the above mentioned metabolites. Just a word of caution, SWIM would not recommend these combinations but inevitably people will, SWIM would recommend a sitter until sure why such a seemingly tiny dose of chlordiazepoxide (5mg) would have such an effect. It may be something totally different, some other compound in your body... lots of variables.
clonazepam is not metabolized into any active metabolites that SWIM's marmoset is aware of.
is not a potentiator in the true sense as it is actually an NMDA inhibitor which interferes with the cell memory process, which in turn causes prevents tolerance from occuring when taken concurrently with most addictive substances (morphine
was the particular drug
SWIM is most familiar with as it was used in the study where SWIM first learned of this). It not only prevents tolerance (not completely, but significantly), it also reduces opiod tolerance when take by itself. Now since tramadol is not exactly a traditional opiate
SWIM does not know for sure if it will act similarly to tramadol as with morphine.
So far, the most useful combination SWIM has discovered is tramadol's ability to effectively kill pain while buprenorphine
is in the system which blocks traditional opiods.
SWIM has heard of people having good success with tramadol + carisprodol (this is supposedly similar albiet weaker than the more well known hydrocodone
/carisprodol combo which can be quite dangerous)
Also, for pain relief SWIM's marmost routinely uses 50-100mg tramadol + 400-800mg ibuprofen... But you really need to watch the intake of both substances as the max recommended dose of ibuprofen is 3200mg/day so if necessary and no other options, 100mg tramadol + 800mg ibuprofen could be taken 4 times per day. That is something you really need to discuss with your doctor though before reaching that thresholds.
Everything SWIM has said is just theoretical and SWIM does not recommend trying any of these combinations without consulting your doctor first. Please BE SAFE!!!