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  #1  
Old 28-09-2009, 19:08
Reskay Reskay is offline
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Need to increase Tramadol effect. Please help!

SWIM cannot get the desired effect from tramadol, SWIM has 8 x 50mg left SWIM knows he cannot get the effect anymore. SWIM has tried Grape Juice to no avail.

What can SWIM mix with to get the effect he used to?

Tramadol + Ibruprofen?

Tramadol + Co-dydramol?
  #2  
Old 29-09-2009, 02:23
Herbal Healer 019 Herbal Healer 019 is offline
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Re: Need to increase Tramadol effect. Please help!

It's not grape juice it's grapefruit juice my man.

Other than that, the above is true. Also note that there is a ceiling effect for tramadol & I'm pretty sure 400mg is in excess of that ceiling effect.
  #3  
Old 08-10-2009, 04:08
Villan Villan is offline
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Re: Need to increase Tramadol effect. Please help!

Quote:
Originally Posted by Herbal Healer 019 View Post
It's not grape juice it's grapefruit juice my man.

Other than that, the above is true. Also note that there is a ceiling effect for tramadol & I'm pretty sure 400mg is in excess of that ceiling effect.
yop, dont take more than 400mg a day. tramadol sucks donkey dick.

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No need for this post, "donkey dick" is not a great way to describe tramadol
  #4  
Old 02-09-2010, 03:49
Sassy88 Sassy88 is offline
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Re: Need to increase Tramadol effect. Please help!

My pet ferret thinks mixing 2 acetaminophen and 25-50 mg. of diphenhydramine with her usual tramadol dose seems to enhance the effect- though it's nothing earth-shattering. Just more pronounced. And there is nothing overly dangerous with mixing low dosages of tramadol with low dosages of the other 2 ( to her knowledge ).
  #5  
Old 19-09-2010, 05:27
Ale Ale is offline
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Re: Need to increase Tramadol effect. Please help!

Swim heard there was some positive synergy between Tramadol Hydrochloride and low doses of DXM.
  #6  
Old 26-09-2010, 17:42
zaxthing zaxthing is offline
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Re: Need to increase Tramadol effect. Please help!

Phenergan or vistaril might help--they potentiate conventional narcotics that work in the same receptors in the brain...
  #7  
Old 26-09-2010, 18:18
veritas.socal veritas.socal is offline
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Re: Need to increase Tramadol effect. Please help!

sassy88 mentioned dyphenhydramine, which swim finds will potentiate most opiates and dxm(which is a super long distant cousin to morphine, swim heard, and swim knew a dude who failed urinalysis for opiates, 30hrs after large dxm dose{dxm only}) it will potentiate trams. swim finds 100mg to be a typical potentiation dose!
swim also has found that gabapentin(neurontin) 600-1200mg taken w the trams will potentiate. cannabis? swim definitely has taken 3/4g(750mg,or 15 of the 50's) and been higher than 400 mg. but sicker to the point where more than two hits from a roll up cigarette would make swim puke
  #8  
Old 26-09-2010, 21:04
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Re: Need to increase Tramadol effect. Please help!

Cyclizine is the only potentiator that swim found to work. Be aware swim found tramadol wd the worst , far nastier than morphine,codeine or fentanly wd.

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so true! exactly my experience
  #9  
Old 26-10-2010, 11:54
CCApollo CCApollo is offline
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Re: Need to increase Tramadol effect. Please help!

Taking DXM, even at the therapeutic dose, with Tramadol is a bad idea. This combination can cause Seretonin Syndrome due to Tramadol's effects of the level of Seretonin present. This is what makes is different from traditional opiates, as it has anti-depressant aspects. Some believe that this is also why the withdrawal is more severe, despite the fact that it is a weaker opiate in comparison to the more traditional perscriptions such as Hydrocodone, Oxycodone, ect... In summary, be very careful, as SWIY always should, when combining any sort of medication, OTC or not.

SWIM has read recently that Saint John's Wort may be a suitable drug for potentiatint Tramadol, but SWIM does not have first hand evidence of this. This may not be safe either , as it also effects Seretonin levels, albeit at a much lower level than DXM. SWIM would suggest doing more research into this before trying it, in the interest of saftey.

Be safe, and utilize the great resource that is Drugs Forum, as well as many other credible resources on the Internet. Check your sources, do the research, and stay safe!

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good advice on the serotonin syndrome risk
  #10  
Old 28-10-2010, 17:49
Jasim Gold member Jasim is offline
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Re: Need to increase Tramadol effect. Please help!

St. John's Wort affects serotonin levels to a much greater degree than dextromethorphan does. It's contradictory to say that DXM with tramadol may be unsafe, but to recommend St. John's Wort.

Serotonin syndrome is actually not that easy to get to. When we discuss serotonin syndrome it typically involves potent serotonergic pharmaceuticals that are specifically geared towards increasing levels of serotonin or the monoamines.

Combining pharmaceutical MAOI's with serotonergic agents is the number one cause of serotonin syndrome. Most herbal MAOI's are reversible and not potent enough to contribute to serotonin syndrome under normal circumstances (unless combined with a pharmaceutical SSRI or MAOI).

Tramadol itself does not increase serotonin levels relatively that much. I think combining tramadol with DXM or St. John's Wort should not be a concern for serotonin syndrome. My pet turtle Clover has done both and has reported to ill-effects.

What is of MUCH greater concern is the fact that tramadol lowers the seizure threshold.

Seizures are a very real danger of tramadol use, especially when combined with any agents that increase neurotransmitter levels or that have excitatory CNS action. Tramadol should NOT be combined with other drugs that decrease seizure threshold or in subjects who have a history of seizures or have recently stopped taking a drug that raised seizure threshold (benzodiazepines, gabapentin, chronic alcohol use, etc.).

To be clear, when I say "lowers or reduces seizure threshold" I mean they make it easier to have seizures and likewise to "raise or increase seizure threshold" makes it less likely to have seizures.

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For such a broad spectrum of safety advice.
Good explanations and harm avoidance information
Very true, good advice wrt serotonin syndrome.
  #11  
Old 28-10-2010, 23:54
antialias antialias is offline
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Re: Need to increase Tramadol effect. Please help!

IF anyone is planning on taking a very large dose of tramadol, combine it with a small dose of a muscle-relaxant/anti-epilepticum like clonazepam (but keep an eye on swiys breathing since clona is a benzo) to try to avoid cramps/seizures.

To swim, tramadol is a typical drug that is not really fun when taken alone.. first, some freshly squeezed grapefrugit. Then it should be mixed with first and foremost cannabis (most important) and then a beer or two but not more and if swiy is not too buzzed slip a little clonazepam och valium in the mix but as said before..watch swiys breathing and take this mix with a friend who can watch you if possible.. mixing opioids and gaba's can be dangerous but if swiy don't overdo it will perobably fine. Just don't go to sleep until swiy feel most of the buzz has worn off..
  #12  
Old 27-02-2011, 14:06
zaxthing zaxthing is offline
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Re: Need to increase Tramadol effect. Please help!

Quote:
Originally Posted by Reskay View Post
SWIM cannot get the desired effect from tramadol, SWIM has 8 x 50mg left SWIM knows he cannot get the effect anymore. SWIM has tried Grape Juice to no avail.

What can SWIM mix with to get the effect he used to?

Tramadol + Ibruprofen?

Tramadol + Co-dydramol?
My pet tiger has had some luck with Tramadol+Phenergan to increase effect.
  #13  
Old 27-02-2011, 14:30
zerozerohero zerozerohero is offline
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Re: Need to increase Tramadol effect. Please help!

If one's looking for pain-relieving effects, combining tramadolw ith Ibuprofene is very effective, especially if 600mg Ibuprofen doses are available (mostly soluble form otherwise get 400mg pills that can be cut in halves).
For intense back pains, my blow-up-dick-nickson uses 50 mg tramadol + 600mg ibuprofen 4 times a day, ideally every 8 hours - instead of 50mg, 100mg may be used if really needed.

It is strongly advised to:
- ask the doctor for advice.
- ask the doctor for a prescription of Omeprazole, since ibuprofen gets gastro-toxic at 2400mg/day and one might develop stomach problems.
- keep each intake at least 6 hours apart.

My blow-up-dick-nixon gets excellent results with this combo, even in cases of very severe tooth pain (aka failed root-canal...), where tramadol alone is pretty useless and ibuprofen does not do the trick by itself either. The main use of this combo is for back pains that nothing else relieves anymore (and BUDN does not want to step up to stronger opiates anymore) and results are quite impressive in that guy's case.
  #14  
Old 27-02-2011, 15:48
icekrm icekrm is offline
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Re: Need to increase Tramadol effect. Please help!

Since I crossed tramadol limitsat 400mg,Ive done before that for 2 month binge codein.
Only crapppy "legal" local things to get passed through the time.
Codeine withdrawal now

PS: Since you could start a modafinil short treatment, You should see your tramdol tolerance imbalance.
  #15  
Old 27-02-2011, 16:12
Boagie Boagie is offline
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Re: Need to increase Tramadol effect. Please help!

Either go strung out m8 or try a stronger opiate

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Either post on this forum with less harm increasing one liners or don't post at all.
worst advice i read in ages - this is a harm reduction forum, not an opiate-promotion forum
  #16  
Old 01-03-2011, 13:30
RoboCodeine7610 RoboCodeine7610 is nu online
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Re: Need to increase Tramadol effect. Please help!

Actually, Robo was just about to post a new thread on his findings on how to potentiate (or rather be able to take more) tramadol, and has had results equal to 300mg of codeine, if not even superior.

Robo will put ti in a nutshell here before making a thread:

The reason why tramadol cannot be taken in high doses is because of the risk of seizures.Now if you already have a seizure disorder, this is definitly something you should not do, and Robo is not recomending anyone to do it.It is simply the report of an experiment gone fantastically well.

Basically, swim thought that since you couldn't take more than 400mg without risking a seizure, he should take a drug along with it that prevents seizures while potentiating it's effects, not only being able to take a much larger anmount of the drug, but also take away that speedines that Robo hates so much when taking tramadol.

Anyway, basically swim has been experimenting with clonazepam as a way to prevent seizures when taking variying amounts of tramadol.He did this little by little, increasing the dosage each time and here's the latest result:

Swim took:

T-00 1mg clonazepam

T-10min.1.3g of tramadol

T-40min. 1mg clonazepam

T1:45 2mg clonazepam

It's been exactly 4 hours and 22 minutes since he took the inicial dose and has had no seizures or side effects of any kind so far.He is, however, enjoying an opiate high, IDENTICAL to that of 300mg-400mg of codeine (And swim has been using codeine for 3 years now, on a weekly basis).

Notes of importance:

-Robo chose clonazepam because it is a long-acting benzodiazepine, one of the longest-acting ones.

-Robo already has a mild tolerance to clonazepam at this point, hence the large doses.

-This should NOT be done by people with a history of seizures, or even tramadol-related seizures in the past.

-The results of this experiment were very successful, but Robo in no way recommends this to anyone.If you do this, it's at your own risk.



And lastly, everyone's body reacts differently to different drugs so:

-Know your substance
-Know your body
-Know your source

Robo

RoboCodeine7610 added 4 Minutes and 30 Seconds later...

Oh, and as a side note, before you guys ask:

-Respiratory depression has not been an issue for Robo, at all.Clonazepam causes less respiratory depression than other benzodiazepines btw, so if anyone does this with a different benzo, beware of this risk.

Last edited by RoboCodeine7610; 01-03-2011 at 13:30. Reason: Automerged Doublepost
  #17  
Old 07-03-2011, 10:03
zerozerohero zerozerohero is offline
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Re: Need to increase Tramadol effect. Please help!

My Blow-Up-Dick-Nixon-Doll (a.k.a. BUDND) wishes to provide the following advice regarding the above post by robo: what might work for robo with clonazepam, might not work for others, or might work with other benzos.
BUDND has indeed mixed clonazepam with tramadol without further problems, but without pushing tramadol dosage that far.
BUDND had a horrendous surprise mixing tramadol with another benzo called Librium (Chlordiazepoxide) : 200 mg Tramadol, with their usual effect, were very heavily potentiated by just 5mg librium. It wasn't really potentiation, as the pain-relieving effects of tramadol were not enhnced, but BUDND was just simply completely shot out of his underpants with this combo, whereas mixing the same amont of tramadol with even 2mg of clonazepam would never ever produce such an effect on him.
BUDND wants to advise other users to be very cautious when mixing tramadol and benzos as they are both strong CNS depressants, and everyone should know by now that mixing CNS depresants has cost many lives and many rock-stars to the world already
  #18  
Old 15-03-2011, 02:33
Laudaphun Gold member Laudaphun is offline
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Re: Need to increase Tramadol effect. Please help!

That is quite interesting that 5mg chlordiazepoxide somehow caused such a strong effect when combined with 400mg tramadol, especially when the marmoset who ingested these drugs also experimented and compared the results with 2mg clonazepam.

Firstly, clonazepam in and of itself is not the best substance to enhance the effects of tramadol, however it is a great safety precaution as it is used as an anti-seizure medication. Clonazepam is sometimes prescribed along with tramadol when first initiating a patient to tramadol treatment for the sole reason of the risk of seizures with tramadol use.

SWIM is really irritated as she had a stash of chlordiazepoxide 25mg and 10mg buried in the back yard (not literally) for emergency last resort solution to benzo withdrawl should that ever occur. However they seem to have disappearred and now there is no reason for SWIM to be able to obtain chlordiazepoxide again. SWIM's marmoset would have really liked to experiment with SWIYs results.

Diazepam is very closely related to chlordiazepoxide and many other benzos that have active metabolites are more or less similar in that the majority seem to be metabolized to nordiazepam. This holds true for quite a few of the 1,4-benzodiazepines and their similar active metabolites. The triazolo-benzodiazepines such as alprazolam, midazolam, ect typically do not have active metabolites. So it may be worth "very carefully given the previous posters experience" investigating other 1,4-benzodiazepines that are closely related to diazepam. While chlordiazepoxide obviously is a bit of an oddball with its atypical structure, its active metabolites are nordazepam (desmethyldiazepam), temazepam, oxazepam, and some others... So while it is significantly different structurally than diazepam, it shares most of the same active metabolites as diazepam is metabolized via hydroxylation to temazepam which is metabolized to oxazepaam via N-demethylation. Diazepam is also metabolized into nordazepam (desmethyldiazepam) via N-demethylation. So the question SWIM is wondering is if it is the active metabolites which are responsible for such a pronounced effect at such a low dose or the chlordiazepoxide which is active for around 24 hours before it is metabolized to the above mentioned metabolites. Just a word of caution, SWIM would not recommend these combinations but inevitably people will, SWIM would recommend a sitter until sure why such a seemingly tiny dose of chlordiazepoxide (5mg) would have such an effect. It may be something totally different, some other compound in your body... lots of variables.

clonazepam is not metabolized into any active metabolites that SWIM's marmoset is aware of.

DXM is not a potentiator in the true sense as it is actually an NMDA inhibitor which interferes with the cell memory process, which in turn causes prevents tolerance from occuring when taken concurrently with most addictive substances (morphine was the particular drug SWIM is most familiar with as it was used in the study where SWIM first learned of this). It not only prevents tolerance (not completely, but significantly), it also reduces opiod tolerance when take by itself. Now since tramadol is not exactly a traditional opiate SWIM does not know for sure if it will act similarly to tramadol as with morphine.

So far, the most useful combination SWIM has discovered is tramadol's ability to effectively kill pain while buprenorphine is in the system which blocks traditional opiods.

SWIM has heard of people having good success with tramadol + carisprodol (this is supposedly similar albiet weaker than the more well known hydrocodone/carisprodol combo which can be quite dangerous)

Also, for pain relief SWIM's marmost routinely uses 50-100mg tramadol + 400-800mg ibuprofen... But you really need to watch the intake of both substances as the max recommended dose of ibuprofen is 3200mg/day so if necessary and no other options, 100mg tramadol + 800mg ibuprofen could be taken 4 times per day. That is something you really need to discuss with your doctor though before reaching that thresholds.

Everything SWIM has said is just theoretical and SWIM does not recommend trying any of these combinations without consulting your doctor first. Please BE SAFE!!!
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Old 26-07-2011, 15:45
wrek1 wrek1 is offline
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Re: Need to increase Tramadol effect. Please help!

Quote:
Originally Posted by Creeping Death View Post
You should just squirm in pain like the filthy jukie that you are!

Theres not much you can do other than take MORE pills. Unless you lower your tolorance; then the same dose will work again.
Thats low, what an insult to the question which is asked? people ask for help here and you are just giving them shit.... stick a pole up ur ass and get some common sense to help others or dont answer the question at all
  #20  
Old 26-07-2011, 17:36
Snipez Snipez is offline
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Re: Need to increase Tramadol effect. Please help!

Would one feel more analgesic effect from taking all of their tramadol dose at once or taking half of it first and half of it an hour later? I've read some places that already having tramadol in one's system increases the bioavailability of any more tramadol added but have never seen any citations of clinical studies or anything to prove that so maybe it's just a rumor that started from people's placebo effect. Does anyone have any ideas about that or could cite any reliable sources?
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Old 30-07-2011, 13:02
zerozerohero zerozerohero is offline
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Re: Need to increase Tramadol effect. Please help!

I've just discovered the Hydroxyzine (marketed mostly as Atarax, Vistaril, Quiess, Tranquizine - an 'old-school' antihistamine) is sometimes used to increase the analgesic effects of opiates/opio´ds. Plus, it carries anxiolytic propperties as well.

It is questionable wether or not this would work with Tramadol and there is, as always with CNS depressant drugs, the risk of increased risks linked to CNS depressants - be very carefull when mixing those and do so only under supervision of a sitter the first few times until you're certain of the outcome of this combination.

In my honest opinion it's worth a try, keeping dosages of both drugs as low as posible to avoid adverse effects.
If anyone has any relevant documentation on this, it would be highly appreciated.
I'll be trying this by myself ASAP as i'm in possession of legally prescribed tramadol and hydroxyzine. I'll report back when i'm done.
  #22  
Old 10-08-2011, 02:20
Gryzor Gryzor is offline
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Re: Need to increase Tramadol effect. Please help!

If you want to potentiate tramadol use a benzodiazepine like clonazepam or diazepam, carisoprodol works very well as does weed and the anti-histamines benedryl or atarax/hydroxyzine as previously mentioned. Don't expect anything mind blowing...

The benzos are more synergistic than potentiating but will allow you to get the idea of seizing out of your head and they will reduce the risk of a seizure (the seizure risk is highly blown out of proportion). The seizure risk however is huge when tramadol is being abused to get high off i.e. using 500mg or more at once. I wouldn't use tramadol however if you or anyone else in your family tree had a history of seizures.

Clomipramine and tramadols distant cousin (or possibly copy without the opioid part )Venlafaxine have much higher seizure percentages on an mg to mg basis. The problem is you will want to take 400mg of tramadol but defo not 400mg of a trycyclic.

Serotonin syndrome is very rare and 1x50mg pill of tramadol has 1/50th the serotonin reuptake effect compared to the SSRI Zoloft/Sertraline at 1x50mg. People who haven't taken SSRIs in their lives that don't have a tolerance to them, in the first 4-5 days you get an almighty "whack" from them. Yawning, sleepiness strange cravings and appetite etc. that would not be a good time to take tramadol with an ssri.

If you have taken SSRIs for an extended period of time it would be pretty safe to combine tramadol with an SSRI but not at an abusive dosage. I have done so and doctors even shrinks okayed it. However I was weaning off tramadol at the time (500mg a day self medication with 100mg sertraline)

Of course you can always give grapefruit juice a try as tramadol is detoxed by 2 enzymes and this inhibits one of those.

Gryzor added 4 Minutes and 57 Seconds later...

Oh by the way Ritalin (Methylphenidate) is also used to enhance the effects of opiates but i personally wouldn't touch that sh1t drug with a 10 foot barge pole, let alone as all stimulants that i know of lower seizure threshold. Tramadol and ritalin would be a recipe to end up in the ER but I just thought I'd share that knowledge with people....I find it odd it can help the effectiveness of opiates....

Gryzor added 1355 Minutes and 59 Seconds later...

Quote:
Originally Posted by Herbal Healer 019 View Post
It's not grape juice it's grapefruit juice my man.

Other than that, the above is true. Also note that there is a ceiling effect for tramadol & I'm pretty sure 400mg is in excess of that ceiling effect.
SWIM used Tramadol HCL as self-medication against refractory derpression for 4 years and occasionally abused it to a maximum of 800mg in one go.

It was a mistake by SWIM to use 800mg whilst rushing to gather things whilst late for, work he took a double dose by accident.
SWIM isn't sure if tramadol has a ceiling in all honesty - I think the ceiling depends on the individuals CYP2D6 enzyme capacity.
SWIM used the drug daily having to up the dose by ~50mg every 6-8 weeks to achieve the same total remission from depression effect.

Gryzor added 241 Minutes and 35 Seconds later...

I basically forgot the daddy of all CYD inhibitors - 600mg Cimetidine HCL. Apparently white grapefruit juice 100% is best of the grapefruits. (beware of that concentrated rubbish which may contain 10% real juice) take it about 45 mins before you dose, its trade name is Tagamet afaik. Tonic water also has its uses (quinine). Good luck.

Last edited by Gryzor; 10-08-2011 at 02:20. Reason: Automerged Doublepost
  #23  
Old 13-08-2011, 07:26
RoboCodeine7610 RoboCodeine7610 is nu online
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Re: Need to increase Tramadol effect. Please help!

Robo actually has had pretty drastic results with hydroxizine.It potentiates the opiate effect, making it mask the stimulation.I'd say it potentiates tramadol euphoria 200%-250%.

Robo
  #24  
Old 14-08-2011, 21:12
Gryzor Gryzor is offline
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Re: Need to increase Tramadol effect. Please help!

Quote:
Originally Posted by RoboCodeine7610 View Post
Robo actually has had pretty drastic results with hydroxizine.It potentiates the opiate effect, making it mask the stimulation.I'd say it potentiates tramadol euphoria 200%-250%.

Robo
How many mgs of each are we talking about? I find hydroxyzine nice as anti histamines go but 60mg had no discernible effect for me. I'm sure thats much too low.
  #25  
Old 15-08-2011, 11:39
RoboCodeine7610 RoboCodeine7610 is nu online
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Re: Need to increase Tramadol effect. Please help!

Robo had best results with 200mg 30 min. before the tramadol.

Robo

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