Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News
Go Back   Drugs Forum > DRUG-FORUMS > Various drugs not covered by other forums > Antidepressants
Mark Forums Read
Register Tags

Notices

 
Thread Tools
  #1  
Old 01-02-2010, 07:44
Flying Mind Flying Mind is offline
Titanium Member
 
Join Date: 20-03-2009
Male from Sao Tome and Principe
Posts: 333
Flying Mind probably knows what they are talking about.Flying Mind probably knows what they are talking about.Flying Mind probably knows what they are talking about.Flying Mind probably knows what they are talking about.
Points: 430, Level: 3 Points: 430, Level: 3 Points: 430, Level: 3
Activity: 0% Activity: 0% Activity: 0%
Neurontin (Gabapentin) as an antidepressant?

SWIM has read a lot of positive experiences with this drug, not so much what its actually prescribed for as it's "off label" uses, particularly depression and social anxiety. SWIM has read several reports where the user describes profound mood-lift, even considered to be recreational and giving a "high".

Many also describe it has therapeutic qualities as-well, Swims describe feeling more open and sociable... After all isn't that part of making progress with one's mental health? Being open and discussing with loved ones??

SWIM noticed this hasn't been brought up on the Antidepressant forum and felt it justly deserved discussion.

Last edited by Flying Mind; 01-02-2010 at 07:55.
  #2  
Old 09-02-2010, 15:27
chibi curmudgeon Gold member chibi curmudgeon is offline
Gold Finger
 
Join Date: 26-11-2008
33 y/o Female from United States
Posts: 1,346
chibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPACchibi curmudgeon must think in IUPAC
Points: 2,288, Level: 7 Points: 2,288, Level: 7 Points: 2,288, Level: 7
Activity: 10.3% Activity: 10.3% Activity: 10.3%
Re: Neurontin (Gabapentin) as an antidepressant?

Yeah, it's kind of a 3rd-line antidepressant or, more often, a mood stabilizer, similar to the other mood stabilizer/anticonvulsants out there. I've heard its side effects described more as a drunk feeling (though I'm kind of loathe to say this lest some idiot try swallowing a handful) which may make it more helpful in anxiety or mania.

You're more likely to see it for partial seizures or neuropathic pain than depression (or bipolar disorder.) From what I've heard, it makes one more sociable or less anxious in the same way that alcohol does--you're too sedated to be nervous or upset. If it works, great, but I'd never recommend it for mood/anxiety disorders unless several other drugs had been tried first.

Again, I must stress that this isn't a substitute for alcohol, no one should be trying to get drunk off of it.

Edit: Um, just wanted to point out that this isn't a personal experience....

Post Quality Evaluations:
Thanks for sharing personal exp!

Last edited by chibi curmudgeon; 22-02-2010 at 23:25. Reason: added clarification
  #3  
Old 09-02-2010, 16:12
pinksox pinksox is offline
Palladium Member
 
Join Date: 11-02-2009
Female from United States
Posts: 668
pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.
Points: 1,472, Level: 5 Points: 1,472, Level: 5 Points: 1,472, Level: 5
Activity: 5.6% Activity: 5.6% Activity: 5.6%
Re: Neurontin (Gabapentin) as an antidepressant?

Personally, having used both for other issues, but having well-controlled bipolar d/o, SWIM has found Lyrica(pregabalin) to work much more effective--both for pain and as a mood elevator/stabilzer than Neurontin(gabapentin). She uses it primarily for MS-related myalgia pain, but has found it does have a definite "mood brightening" effect as well.

There used to be an old analogy for Fentanyl--way back when SWIM was a "baby medic" that, "Fentanyl is like morphine on steroid." While, dosing differences aside, SWIM has still found that her patients greatly prefer morphine for pain control(and because morphine doesn't have as severe complications as Fentanyl can). Fent has fallen more and more out of favor in the acute care setting.

Having taking both and Neurontin for several months in increasing doses over 6 months several years back before discarding it as "useless." She now equates Lyrica as being the equivalent of Neurontin on steroids." For her, and many patients, it's just much more effective...and is starting to increasingly be used off-label as a mood stabilizer and anti-depressant. It's also reported to help with anxiety as well.

Post Quality Evaluations:
Thanks for sharing personal exp!
  #4  
Old 22-02-2010, 04:33
Flying Mind Flying Mind is offline
Titanium Member
 
Join Date: 20-03-2009
Male from Sao Tome and Principe
Posts: 333
Flying Mind probably knows what they are talking about.Flying Mind probably knows what they are talking about.Flying Mind probably knows what they are talking about.Flying Mind probably knows what they are talking about.
Points: 430, Level: 3 Points: 430, Level: 3 Points: 430, Level: 3
Activity: 0% Activity: 0% Activity: 0%
Re: Neurontin (Gabapentin) as an antidepressant?

Thanks both SWIYs for informative responses.

The one concern/question that bothers SWIM is how likely would he be able to obtain a script for it(
gabapentin) from his GP for treatment-resistant depression and or mood stabilizer. Unlikely?

SWIM has taken at least two different anti-convulsants in the past (as mood stabilizers, 4+ years ago) but this is a new doctor without any of his previous treatment/medical records.

SWIM is very interested in this medicine, but what are the chances he can get it prescribed off-label?


Last edited by Flying Mind; 22-02-2010 at 05:34.
  #5  
Old 23-02-2010, 10:19
pinksox pinksox is offline
Palladium Member
 
Join Date: 11-02-2009
Female from United States
Posts: 668
pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.
Points: 1,472, Level: 5 Points: 1,472, Level: 5 Points: 1,472, Level: 5
Activity: 5.6% Activity: 5.6% Activity: 5.6%
Re: Neurontin (Gabapentin) as an antidepressant?

Quote:
SWIM is very interested in this medicine, but what are the chances he can get it prescribed off-label?
Most likely. In SWIM's experience, since neither medication has a huge abuse potential, most docs will write for it for the asking. It's pretty much in the category of, "doing no harm, but might possibly help," and thus, most docs are willing to let their patients give it a trial.
  #6  
Old 24-02-2010, 01:24
Flying Mind Flying Mind is offline
Titanium Member
 
Join Date: 20-03-2009
Male from Sao Tome and Principe
Posts: 333
Flying Mind probably knows what they are talking about.Flying Mind probably knows what they are talking about.Flying Mind probably knows what they are talking about.Flying Mind probably knows what they are talking about.
Points: 430, Level: 3 Points: 430, Level: 3 Points: 430, Level: 3
Activity: 0% Activity: 0% Activity: 0%
Re: Neurontin (Gabapentin) as an antidepressant?

OK thank SWIY. SWIM Feel much better about asking for it now.

Last edited by Flying Mind; 25-02-2010 at 17:27.
  #7  
Old 25-02-2010, 10:00
Lukeoca Lukeoca is offline
Titanium Member
 
Join Date: 10-08-2008
Male from United Kingdom
Posts: 103
Lukeoca is captain of the psychonauts.Lukeoca is captain of the psychonauts.
Re: Neurontin (Gabapentin) as an antidepressant?

I for one will be interested to hear about SWIYs response to Gabapentin for the above purposes. Has swiy not had much luck with traditional anti depressants for depression and social anxieties?

Does Gabapentin / other mood stabalisers have a wearing in period similar to that associated with anti-depressants?
Good luck!
  #8  
Old 25-02-2010, 13:06
MrG MrG is offline
GHB
Moderator
 
Join Date: 22-10-2006
43 y/o Male from Earth
Posts: 3,577
Blog Entries: 3
MrG is a true resource and beyond reputeMrG is a true resource and beyond reputeMrG is a true resource and beyond reputeMrG is a true resource and beyond reputeMrG is a true resource and beyond reputeMrG is a true resource and beyond reputeMrG is a true resource and beyond reputeMrG is a true resource and beyond reputeMrG is a true resource and beyond reputeMrG is a true resource and beyond reputeMrG is a true resource and beyond repute
Points: 9,137, Level: 13 Points: 9,137, Level: 13 Points: 9,137, Level: 13
Activity: 4.5% Activity: 4.5% Activity: 4.5%
Re: Neurontin (Gabapentin) as an antidepressant?

One thing to bear in mind is that the medical community are known to refer to Neurontin (GABApentin) as 'Morontin'. This is, apparently, because of the, often reported, 'slow' nature of their patients who are prescribed it for daily use.

SWIM has used GABApentin at an 800-1200mg dose in the evening on occasion and found that there is a very noticeable 'mellow fog' that lasts up until about lunchtime the next day. I can only imagine that users who are taking it multiple times during the day under prescription are probably going to experience this state persistently. Therein lies it's effectiveness as an anxiolytic, the anxiety may be kept at bay, but so is one's normal thought processing speed.
  #9  
Old 25-02-2010, 17:24
Flying Mind Flying Mind is offline
Titanium Member
 
Join Date: 20-03-2009
Male from Sao Tome and Principe
Posts: 333
Flying Mind probably knows what they are talking about.Flying Mind probably knows what they are talking about.Flying Mind probably knows what they are talking about.Flying Mind probably knows what they are talking about.
Points: 430, Level: 3 Points: 430, Level: 3 Points: 430, Level: 3
Activity: 0% Activity: 0% Activity: 0%
Re: Neurontin (Gabapentin) as an antidepressant?

Quote:
Originally Posted by pinksox View Post
Personally, having used both for other issues, but having well-controlled bipolar d/o, SWIM has found Lyrica(pregabalin) to work much more effective--both for pain and as a mood elevator/stabilzer than Neurontin(gabapentin). She uses it primarily for MS-related myalgia pain, but has found it does have a definite "mood brightening" effect as well.

Well SWIM has an update. He went to his doctor and talked to him about peaked interest in Neurontin.

They briefly discussed it, then he (not SWIM) brought up Lyrica. He described it to be more thoroughly proven effective for mood (i.e. more clinical trials done on it showing so).

SWIM will begin taking it as prescribed tonight, he has no interest in abusing it.

One thing he found funny is one of the listed side-effects...

Quote:
Some of the most common side effects of LYRICA are dizziness, sleepiness, weight gain, blurred vision, dry mouth, feeling "high", swelling of hands and feet, and trouble concentrating.
That is the first time he's seen a side-effect of "feeling high", lol.

In time SWIM will report back perceived effectiveness.

Last edited by Flying Mind; 25-02-2010 at 21:15.
  #10  
Old 01-03-2010, 18:46
Neznam Neznam is offline
Silver Member
 
Join Date: 12-12-2009
25 y/o Male from Canada
Posts: 493
Neznam is captain of the psychonauts.Neznam is captain of the psychonauts.Neznam is captain of the psychonauts.
Re: Neurontin (Gabapentin) as an antidepressant?

Swim has been prescribed Gabapentin for nerve pain and has never felt any rise in his mood, perhaps because it was prescribed for heroin w/d. Later his doc told him he could use them for sleep as he was having trouble sleeping. Even at doses of 2100mg before going to bed swim never felt drowsy or tired.

He was also given amitriptyline for sleep, but it doesnt seem to do anything for swim. His sleep and mood are not affected. Swim was also using valium for a month but had to stop as to not get addicted and they stopped working for swim too.

Perhaps swim is just affected weirdly by drugs. Some have reported getting a high like feeling from gabapentin and perhaps this is why they get a rise in their mood?
  #11  
Old 01-03-2010, 19:03
bluntshell bluntshell is offline
R.I.P.
 
Join Date: 23-01-2010
28 y/o Male from United States
Posts: 221
bluntshell probably knows what they are talking about.bluntshell probably knows what they are talking about.bluntshell probably knows what they are talking about.bluntshell probably knows what they are talking about.
Points: 851, Level: 4 Points: 851, Level: 4 Points: 851, Level: 4
Activity: 0% Activity: 0% Activity: 0%
Re: Neurontin (Gabapentin) as an antidepressant?

SWIM was prescribed Gabapentin for nerve pain a few years ago. The Gabapentin did little to help the pain. SWIM wasn't depressed to begin with, so SWIM did not notice any anti-depressant effects.

SWIM did sleep better though while taking the substance.

SWIM did remember that the pharmacists, everytime he went to get a refill, everyone of them, has something bad to say about Gabapentin though. Mostly along the lines of "There are better drugs for this...."

SWIM also remembers combining it with 2c-t-2 and 2c-i with no noticeable difference in the trip. Does the lack of interaction here point to no 5HT activity for from Gabapentin?

I'm wondering where it's anti depressive action comes from...??
  #12  
Old 02-03-2010, 01:25
Neznam Neznam is offline
Silver Member
 
Join Date: 12-12-2009
25 y/o Male from Canada
Posts: 493
Neznam is captain of the psychonauts.Neznam is captain of the psychonauts.Neznam is captain of the psychonauts.
Re: Neurontin (Gabapentin) as an antidepressant?

^ perhaps when some people get the high like feeling, that could be interpreted as anti depressive action? cause they are happy? no idea
  #13  
Old 02-03-2010, 01:43
bluntshell bluntshell is offline
R.I.P.
 
Join Date: 23-01-2010
28 y/o Male from United States
Posts: 221
bluntshell probably knows what they are talking about.bluntshell probably knows what they are talking about.bluntshell probably knows what they are talking about.bluntshell probably knows what they are talking about.
Points: 851, Level: 4 Points: 851, Level: 4 Points: 851, Level: 4
Activity: 0% Activity: 0% Activity: 0%
Re: Neurontin (Gabapentin) as an antidepressant?

I was more talking about the mechanism of action in the brain....

"Gabapentin is structurally related to the neurotransmitter GABA (gamma-aminobutyric acid) but it does not modify GABAA or GABAB radioligand binding, it is not converted metabolically into GABA or a GABA agonist, and it is not an inhibitor of GABA uptake or degradation. Gabapentin was tested in radioligand binding assays at concentrations up to 100 μM and did not exhibit affinity for a number of other common receptor sites, including benzodiazepine, glutamate, N-methyl-D-aspartate (NMDA), quisqualate, kainate, strychnine-insensitive or strychnine-sensitive glycine, alpha 1, alpha 2, or beta adrenergic, adenosine A1 or A2, cholinergic muscarinic or nicotinic, dopamine D1 or D2, histamine H1, serotonin S1 or S2, opiate mu, delta or kappa, cannabinoid 1, voltage-sensitive calcium channel sites labeled with nitrendipine or diltiazem, or at voltage-sensitive sodium channel sites labeled with batrachotoxinin A 20-alpha-benzoate. Furthermore, gabapentin did not alter the cellular uptake of dopamine, noradrenaline, or serotonin."

--rxlist.com

The only action I could find that Gabapentin has is related to calcium-channels which is well above my understanding at the moment....

Actually it seems no one really knows how Gabapentin works, just that it does....sometimes....
  #14  
Old 18-04-2010, 12:52
Troppo Troppo is offline
Titanium Member
 
Join Date: 17-02-2010
Male from Australia
Posts: 253
Troppo is on the way upTroppo is on the way upTroppo is on the way up
Points: 689, Level: 4 Points: 689, Level: 4 Points: 689, Level: 4
Activity: 0.4% Activity: 0.4% Activity: 0.4%
Pregabalin and gabapentin experience

Swim has taken up to 300 mg. pregabalin per day, 225 mg at night and the other 75 mg during the day (about 12-18 hours later). The drug produced a happy feeling plus a relaxed sedation and tingly, heavyish feeling about an hour after the main dose was taken, and also a decent sleep. The only annoying thing swim found about this drug was an unbelievably quick tolerance rate; swim went from taking 75 mg per day up to 300 mg in only 5 days or so because of an unusually rapid tolerance to the effects (especially the sedative effect). Also noted was a feeling of strong discomfort if a whole day's dose was taken at bedtime and not spread out over the 24 hours to cover for the drug's short half-life. Swim became too concerned about the dose escalation to keep on taking this drug regularly, but a bit more persistence may have found a dose that kept working long-term as an antidepressant. Swim thinks the effective dose for himself could be close to the maximum of 600 mg per day.

Swim also had a bit of experience with gabapentin several years ago and found it to be quite similar to pregabalin, but swim's gabapentin doses were fairly low, and gabapentin was never tried at medium-high daily dose.
  #15  
Old 18-04-2010, 18:39
DextroClonazyCodone DextroClonazyCodone is offline
Silver Member
 
Join Date: 02-04-2010
26 y/o Male
Posts: 465
DextroClonazyCodone is a decent psychonaut.DextroClonazyCodone is a decent psychonaut.
Points: 317, Level: 2 Points: 317, Level: 2 Points: 317, Level: 2
Activity: 0% Activity: 0% Activity: 0%
Re: Neurontin (Gabapentin) as an antidepressant?

SWIM has Bipolar, and reads up on the latest and greatest treatments. He has heard mixed reviews of Gabapentin. Some folks say it saved their lives like no other mood-stabilizer-type medication. Others say it is useless. The good thing is, that doctors are starting to become open to prescribing this (and a handful of other "off-label" antidepressants). I think the days of the SSRI only treatment are changing! SWIM, for his depressive side, takes and SNRI (which helps with anxiety, not depression, oddly enough), and Adderall (which is a miracle, literally).
  #16  
Old 19-04-2010, 02:46
Troppo Troppo is offline
Titanium Member
 
Join Date: 17-02-2010
Male from Australia
Posts: 253
Troppo is on the way upTroppo is on the way upTroppo is on the way up
Points: 689, Level: 4 Points: 689, Level: 4 Points: 689, Level: 4
Activity: 0.4% Activity: 0.4% Activity: 0.4%
Re: Neurontin (Gabapentin) as an antidepressant?

Can't find the 'edit' option (wtf?) so posting a quick new message just to add a correction to my last post here. When swim tried pregabalin (Lyrica) as stated above he was in the process of suddenly stopping cannabis use, so this may easily have given a distorted reaction and contributed to his need to raise the dosage abnormally quickly (to try and deal with the insomnia and general restlessness caused by no longer smoking). He had also quit drinking about a month earlier after being a heavy daily drinker, so this may also have caused an abnormal tolerance situation.

Swim still wants to try either this drug or gabapentin/Neurontin as a long-term antidepressant. Gabapentin is very much cheaper so swim hopes his doctor will allow him an extensive trial, up to maximum dosage. He also hopes it may reduce his desire to use other things like alcohol and weed to deal with his depression and insomnia. He will post his results on this site in future.
  #17  
Old 07-11-2010, 05:18
penta penta is offline
Silver Member
 
Join Date: 07-12-2007
30 y/o Male from United States
Posts: 81
penta is an unknown quantity at this point
Re: Neurontin (Gabapentin) as an antidepressant?

Swim fully believes that Gabapentin can be a very useful antidepressant for someone who is not receiving benefits from other antidepressants.

Swim also uses Gabapentin for stimulant comedown / withdrawal, and it definitely works unbelievably amazing! All depression is completely removed, and Swiy's body will feel unbelievably amazing. Swiy will not regret a single thing after taking Gabapentin.

However, do be care about the dosage you would take. For normal depression, Swiy should start at 600mg/2 times a day, then move up if needed. For stimulant comedown / withdrawal, Swim believes that 1,800mg is a good starting dosage - increasing more if need be.
  #18  
Old 07-11-2010, 16:34
Lukeoca Lukeoca is offline
Titanium Member
 
Join Date: 10-08-2008
Male from United Kingdom
Posts: 103
Lukeoca is captain of the psychonauts.Lukeoca is captain of the psychonauts.
Re: Neurontin (Gabapentin) as an antidepressant?

Is Gabapentin one of those drugs that traditionally loses effect over time and isn't particularly viable for long term depression or anxiety?

SWIM would like to try this drug, but recently through some research about the sigma 1 receptor, came across Fluvoxamine - the most potent sigma 1 receptor AGONIST in the class of SSRIs.
It has worked better than anything for SWIM - even from the first few days or so, barely any side effects but he takes it with his other medication Methylphenidate slow release (DNRI).

SWIM recognises this is off topic, but for treatment resistant anxiety (with some depression) and people looking at this thread for other options, Fluvoxamine really seems to work. Having tried 3 SSRI's - Citalopram, Fluoxetine and Venlafaxine with no success, SWIM would say this is the best one for anxiety / obsessive thoughts. Swim thinks it may be easier to get a doctor to prescribe Fluvoxamine than Gabapentin for dep/anx, so may be an option for someone out there.
  #19  
Old 08-12-2010, 01:44
Sassy88 Sassy88 is offline
Silver Member
 
Join Date: 08-12-2009
Female from United States
Posts: 61
Sassy88 is learning how to become a psychonaut.
Points: 43, Level: 1 Points: 43, Level: 1 Points: 43, Level: 1
Activity: 0.3% Activity: 0.3% Activity: 0.3%
Re: Neurontin (Gabapentin) as an antidepressant?

My pet ferret has just recently started taking neurontin and found it effective on many levels, thus its general overuse by doctors for various 'off-label' conditions. It seems to mix well with tramadol for overall pain relief ( though minor ) and greatly relaxes my pet ferret, which assists with stress headaches and a good night's sleep.

As for the question of tolerance, my pet ferret has found just skipping a day between doses pretty much keeps tolerance low. It also helps that neurontin seems to have a long half-life. She can taken a dose in the early evening and still feel good until noon the next day.

Share this on:

Tags
depression treatment, gabapentin, mood stabiliser, mood stabilizer, neurontin

Thread Tools


Similar Threads
Thread Thread Starter Forum Replies Last Post
Drug info - Gabapentin (Neurontin) Nicaine Downers and sleeping pills 80 28-02-2014 00:10
Dose - Neurontin AKA Gabapentin for sleep after lyrica (Pregabalin) cballhp Downers and sleeping pills 4 27-05-2012 14:00
Adderall XR & Neurontin (Gabapentin)? sundaymorning67 Adderall 9 31-01-2012 03:57
Combinations - LSD + Neurontin (Gabapentin) stefan22 LSD 2 04-11-2008 01:43

» New Threads
Quitting with subutex
Last post by opiatebattler
6 Replies, 85 Views
Codeine Vs Tramadol
Last post by Hamish
5 Replies, 224 Views
Looking for advice to help quit...
Last post by anon9871
2 Replies, 34 Views
Cocaine experiences
Last post by Dwhoneil
203 Replies, 69,472 Views
Are there any other mothers out...
Last post by Cesareo
8 Replies, 587 Views
My time to give up Tramadol
Last post by allme
7 Replies, 287 Views
Borderline personality disorder...
Last post by hotdogfrenchfries
11 Replies, 396 Views
Colic child
Last post by Name goes here
1 Replies, 17 Views
Is this a for-life thing for you?
Last post by hotdogfrenchfries
11 Replies, 521 Views
When do you know you should put...
Last post by BabyLuve
0 Replies, 22 Views
» New Wiki Articles

Sitelinks: Information:

All times are GMT +1. The time now is 11:30.


Copyright: SIN Foundation 2003 - 2014, All rights reserved
"Wiki" powered by VaultWiki v3.0.20 PL 1.