2C-IP Drug Info 2,5-Dimethoxy-4-isopropylphenethylamine hydrochloride
Hi all,
I've recently come across the following chemical and cannot find much information online. Its molecular formula does show up in this forum, but only 4 times in the middle of PiHKAL synthesis(with relation to 2C-P).
2C-IP (2,5-dimethoxy-4-isopropylphenethylamine), as it should be called following Shulgin nomenclature, is the branched analog of 2C-P (2,5-dimethoxy-4-propylphenethylamine). Rather than a 'straight' three carbon chain from the 4' phenyl ring position, the three carbons are arranged with two of them branching from the third, as shown below:
I believe the 2C-Is name was coined by a vendor for reasons best known to themselves.
Not much is known about the active dose, but it may well be higher than typical for phenethylamines. The amphetamine analogue of 2C-IP, DOIP(2,5-dimethoxy-4-isopropylamphetamine) was found by Shulgin to be around 10x less potent than it's unbranched equivalent DOPR (2,5-dimethoxy-4-propylamphetamine). It's likely 2C-IP suffers similarly from reduced potency. I would assume this is because the branching of the 4' sidechain creates steric hindrance, reducing the affinity of the chemical for 5-HT2 receptors.
It's impossible to draw direct conclusions though, so any experimentation with this substance should proceed with extreme caution (e.g. starting at very low milligram doses and working up incrementally over many weeks so that tolerance is not a contributing factor).
So is it of interest? Probably not. It may have some unique subtleties of its own at the right dose, but Shulgin didn't seem to think it was worth persuing. It's unlikely to be anything groundbreaking since the 2C family is already pretty diverse, so it seems improbable that this compound offers anything novel.
