new stimulant skeleton?

[anj0vis]

I posted about a new PhD thesis on the Drugnews board:
http://ethesis.helsinki.fi/julkaisut.../vk/pihlainen/ liquidch.pdf

in addition to interesting development in CG/MS technique, it also shows a few very interesting analogues of common drugs. See pages 34-35. It shows formulas for numerous known drugs and numerous analogues of known drugs. See compound no. 4, it looks interesting. Chemical name would around alpha-methyl-MDMA or similar (correct me those who know better).
This led me to the idea to substitute amino group into the place of alpha-methyl group in amphetamine compounds. Is this alpha-amino-phenethylamine (AAPEA?) ever been tested or researched anywhere? Would the 4-x-2,5-dimethoxy-AAPEA show psychedelic activity between 2c-x series and DO-x series? The amino group would be a bit smaller than methyl group (N has electronegativity of 3.0, while C has 2.5) and hydrogen donation possibility would thus be smaller than in amphetamine skeleton. But if I remember correctly, it was not much of an issue in the alpha-position in PEA skeleton (according to the 5ht2 receptor model), so it might not be an issue. Would the geometric configuration of this alpha-amino group be a problem for activity? Edited by: nanobrain