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Old 12-01-2009, 18:48
killerfromsky killerfromsky is offline
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Zolpidem+Zopiclone solubility?

What is are the solubility rates of Zolpidem in water?

Are there different versions of Zolpidem or Zopiclone? Like a HCl version?

Thanks in advance!


*EDIT*
Already got the answer:

Further, zolpidem salts, especially those that have good water solubility can be formulated into parenteral pharmaceutical dosage forms such as injectable compositions. Such injections should preferably consist of a sterile aqueous solution of the corresponding salt of zolpidem, with or without common excipients such as sodium chloride to avoid haemolysis and a physiologically acceptable buffer. In the following table, the solubility of zolpidem and various salts thereof in water at 20° C. are given in mg/ml:

Zolpidem 0.13
Zolpidem tartrate 18.8
Zolpidem hydrogentartrate 19.9
Zolpidem tosylate 22.2
Zolpidem hydrochloride monohydrate 110.0
Zolpidem sulfate 150.4
Zolpidem mesylate 432.0


Now how do you know what form of zolpidem is in the pills?

Last edited by killerfromsky; 12-01-2009 at 18:56.
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