Drug info - Debate: Why do drugs not affect some?

[MindNRA]

I see a lot of threads here about people who take E but it doesn't affect them. Which brings up a question of why? Why are some people affected very strongly by drugs and why some are not affected by some drugs at all. I am looking for a sort of debate, do you think its their brain chemistry and what specifically can be different about ones brain that will make him immune to E. Do you think its the delivery system to the brain ie stomach, liver - not processing it in time or too slow to cause any effect.

What is your personal opinion on why does one drug affect someone different. We all know they do but why?

MindNRA added 2 Minutes and 31 Seconds later...

And to clarify, I am not talking about tolerance. I am talking about people trying E for first time and now feeling anything.