Pharmacology - Meathod for reverseing dextroamphetamine tollerence

[andrewanarchy]

There is a well known phenomenon that occurs in animals when exposed to amphetamine stimulants, and has been studied generously with dextroamphetamine called "behavioral sensitization". This is a phenomenon where after repeated exposure to amph the animals exhibit an escalating increased response to amph in their behavior "usually the amount of locomotion". Basically this means when they are administered amph repeatedly they develop reverse tolerance!

SWIM was reading about this and uncovered the small quanta of research regarding the human equivalent to this. After studying various medical abstracts he began experimenting, attempting to reduce and hopefully return to a state of no-tolerance. SWIM attempted this by dosing Dexedrine for one day taking his normal dosage, then taking a day or two off before consuming Dexedrine again for a day. He found that his tolerance quickly subsided after about two weeks with a notable difference occurring at the one week point. Throughout this period SWIM had to lower his dose as his tolerance was decreasing, and by the end of two weeks his tolerance was very close to what it was when he first started taking Dexedrine.

SWIM also mentioned to me that he subjectively believed this method was a much faster and effective method to reduce tolerance than a period of total absence, taking nmda-antagonists, or dopamine precursors supplements, because he had tried those methods on previous occasions with only limited success.



The method is: take your normal dose, don’t take any the next day. Continue this for 1-2 weeks or until a satisfactory tolerance level is reached. As tolerance reduces dose should be equally reduced to achieve an effect equivalent to that from what the effect is when the period began. For increased effectiveness randomly replace some of the single days without Dexedrine with double days without; not changing the single days with.

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interesting post