ketamine for depression

[Niteflights]

Since the study was first published that low dose ketamine acts as a highly effective rapid acting antidepressant, several of the big pharmaceutical companies have already submitted patents for novel ketamine like derivatives which exhibit the antidepressant effects of ketamine without the psychotomimetic effects. Since the first studies are now a couple years old, SWIM wonders, has anyone routinely utilized low dose ketamine as an antidepressant for an extended duration? If so, are the antidepressant effects consistent and long lasting, and does the low dose avoid the heavy tolerance issues that develop with recreational ketamine use? andrei