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Old 30-08-2008, 01:04
tupsterlift tupsterlift is offline
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Phenylalanine + sodium borohydride ?

Hi everyone (bigup for this very good forum)

1 have bought 30grams of l-phenylalanine (18,50eu)

and 1 would like to know how to make amfetamine from this product.
1 bought this because first of all I found this post that tells me it is plausible:

A surprisingly simple synthesis is possible from the amino acid
phenylalanine, which is available at health food stores.
Phenylalanine is 2-amino-3-phenylpropanoic acid, which is more or less amphetamine with a COOH where the CH3 should be at the end of the chain. Thionyl chloride will replace the OH with a Cl, which falls off and is replaced by H when you give it lithium aluminum hydride, sodium borohydride, or hydrogen gas and nickel/platinum. If you use hydrogen and metal for that step, you'll have to reduce the carbonyl group with one of the hydrides, so best save time + effort and use them and do both reductions at once. When that carbonyl is reduced, you now have amphetamine.

Ok, now here says 1 should give the phenylalanine lithium aluminum hydrid or sodium borohydride.

The only product 1 found, but not yet bought is sodium borohybride, this is available in powder.

Now how do 1 need to "give" the sodium borohybride to the phenlalanine?

Thank you in advance, an non-native english speaker.

tupsterlift added 17 Minutes and 9 Seconds later...

1 is a chemical novice.

was first thinking of simply mixing both because both substances are only available in powder (as far as I found).

1 assume that "giving" sodium borohydride to phenylalanine is mixing them both?

But how much sodium borohydride do 1 need to mix with 30grams of phenylalanine ?

Thanks in advance.

Last edited by tupsterlift; 30-08-2008 at 01:04. Reason: Automerged Doublepost
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