Overdose - Ibuprofen poisoning: Basics, infos & experiences

[0utrider]

This thread is supposed to be about infos & experiences with Ibuprofen poisoning. To avoid this, one should always consider a Cold-Water-Extraction: CWE FAQ: Links, Lists & Manuals !

I can, again, just stress the need to go to the hospital, if one feels sick! Don't play with your help, these steps here described are rather used for prevention than treatment. Self-treatment is not an option if you feel seriously sick or if you OD'd!!!!
I guess its always a good decision to have a healthy nutrition and take longer breaks between usage. Also drinking water is always adviced. Further information needed.

I'll start with a short summary:

Therapy:

Therapy is largely symptomatic. In cases presenting early, gastric decontamination is recommended. This is achieved using activated charcoal; charcoal absorbs the drug before it can enter the systemic circulation. Gastric lavage is now rarely used, but can be considered if the amount ingested is potentially life threatening and it can be performed within 60 minutes of ingestion. Emesis is not recommended. The majority of ibuprofen ingestions produce only mild effects and the management of overdose is straightforward. Standard measures to maintain normal urine output should be instituted and renal function monitored. Since ibuprofen has acidic properties and is also excreted in the urine, forced alkaline diuresis is theoretically beneficial. However, due to the fact ibuprofen is highly protein bound in the blood, there is minimal renal excretion of unchanged drug. Forced alkaline diuresis is therefore of limited benefit. Symptomatic therapy for hypotension, GI bleeding, acidosis, and renal toxicity may be indicated. Occasionally, close monitoring in an intensive care unit for several days is necessary. If a patient survives the acute intoxication, he/she will usually experience no late sequelae.