Ecstasy and Wellbutrin - Different reaction compared to prior experience

[INSANEPOOKIE]

Hello.

SWIM was prescribed with Wellbutrin SR at 150mg 2x daily about a year ago for an attempted counter to lifelong concentration issues (ADHD). It helped in minute ways. SWIM used X (under 100mg) whilst Wellbutrin SR flowed through hirs body. The X had a rather strong effect and all seemed well the following days/weeks thereafter.

SWIM stopped using Wellbutrin SR and has not been on any other meds afterward. Two months ago SWIM started up on Wellbutrin again, at the same doses. Previously, there were not any noticeable negative side effects from Wellbutrin during the initial use nor through out the entire time of the prescription allotment. This time; however, SWIM had a multitude of nausea attacks that never resulted in the act of vomiting but the sensation made for an unpleasant few weeks. The nausea stopped after SWIMs body adjusted, assumed, that is to say.

SWIM once again dosed with approx. 90mg of X (slightly less than before) and this time, other than a very slight increased sensation in the lips region and dilated pupils, nothing was felt. I believe you would call this a "no magic" event.

The lifestyle SWIM was living and is living currently has not changed overall within the aspects that seem to be relevant:
1. As before, eating a vegtarian based diet.
2. Normal multivitamin intake, along with b12, flax and the other crap that assists a non meat eater from becoming feeble and meek.
3. SWIM was and still is physically active.
4. Ketamine was use once via oral intake about 4 months ago.

DanceSafe's testkit results:




The only difference that seems to be that previously no side effects hit SWIM and this time that ever so fun nausea was felt while adjusting.

The last piece of information may be, perhaps, the real culprit in this case. SWIM had consumed enough food to almost be full about 1 1/2 hours prior to the dosing.

The X from the same batch has been used by others and one pill did the job for them.

Hopefully that's enough data.

Questions:
1. Is it plausible in that during this use of Wellbutrin, the Rx is actually strongly countering the X now?
2. If Wellbutrin did in fact nearly abort the experience, does this mean SWIMs seratonin remains near full capacity?
3. Could this be a simple case of food contributing to a very slow processing of the X and diminishing the experience?
4. If food may have been the villain here, does this mean SWIMs seratonin remains near full capacity?

Another way to ask this:
If something lessens/halts the pleasure/empathy enhancement (assuming the user is not abusing X or something that depletes the reserve) can this indicate the seratonin floodgates were not opened or not fully --- OR does the seratonin depletion still occur?


SWIM is not willing to exceed 120mg in a sitting so double dosing is not an option.

http://www.maps.org/mdma/protocol/review5.pdf (Page 139)

Risks of Neurotoxicity in Clinical MDMA Studies
In assessing risks of MDMA neurotoxicity, it is necessary to separately consider the risks
of serotonergic changes and those of neurocognitive performance changes. This is
because these changes may have different mechanisms and may occur after different
ecstasy exposures. These two areas of risk are discussed below. It is concluded that the
risks of neurotoxicity in volunteers exposed to 125 mg MDMA in a clinical setting are
minimal. While risks of neurocognitive performance changes after one or two doses of
up to 2.5 mg/kg MDMA (175 mg in a 70 kg person) appear to remain very small, risks of
serotonergic neurotoxicity after doses above 125 mg MDMA are difficult to assess.
Furthermore it is important to acknowledge that the risks of MDMA neurotoxicity are
controversial and other knowledgeable scientists believe that risks are more than minimal
(Gijsman et al. 1999; McCann and Ricaurte 2001).