Tryp-2C's & Tryp-3C's : 5-Methoxy,7-Substituted-typtamines

[Zaprenz]

It has been discussed on another forum that if you look at bromo-dragonfly simulating 5-HT (serotonin) as well as 2C's simulating 5-HT then the potential equivalent to 2C's in the tryptamine world could well be 5-methoxy,7-subst-tryptamine. This comparison between B-dragonfly and 5-ht has been discussed before and in Nichols paper but...

The 7-subst in 5-methoxy,7-subst-tryptamines could be the equivalent of the 4-subst in 2C's. [see images below]

This is interesting as Shulgin did not actually test ANY 7-subst tryptamines in TIHKAL and definately no 6,7-Methylenedioxy-tryptamines (which could be seen as the MDMA of the typtamine pattern)

Another interesting piece of information

6-HO-Dopamine : 2,4,5-Trihydroxyphenylethylamine is a dopamine neurotoxin [not to be messed with!!] but shares the same substitution pattern as 2C compounds.

5,7-dihydroxy-tryptamine: Is a known serotonin neurotoxin [not to be messed with!!] but fits the correlation of 5-methoxy,7-subst-tryptamine (possibly as 6-ho-dopamine and 2C did)

No one seems to have done much research on 7-substituted tryptamines let alone 5-methoxy,7-subst-tryptamines. Could well be a very interesting avenue to explore.

Disclaimer: Clearly these are completely unknown compounds so in the wise words of Shulgin

the new activities that might be found in the future may be of quite a different nature, and could potentially be harmful. All things new are, by definition, unknown.

Still would be a very interesting question to ask either Shulgin or Nichols on exploring either Tryp-2C's (5-methoxy,7-subst-tryptamines), Tryp-3C's (5-methoxy,7-subst-alphamethyltryptamines) or plain 7-substituted tryptamines.

Reputation Comments on this post:

keep em coming!