Acetaminophen: The Big Bad Wolf. Large Single Doses
Well, I was doing homework on how badly a single large amount of acetaminophen would injure your liver. And this is what I found.
It's a 2003 study on Acetaminophen levels 4 and 7 hours after 2000 and 3000 mg single doses in healthy adults (meaning no alcohol, I'm sure)
Quote:
Originally Posted by Conclusion
Dosing by weight (i.e., mg/kg) appears to provide a more predictable dose-response relationship. Optimal adult dosing appears to be somewhere in the 20 to 30 mg/kg range based on the premise that the 4 hour level is a trough level that should be in the low therapeutic range.
So for all you responsible acetaminophen ingest-ers. Be smart but safe and base it on body weight.
Also, this doesn't seem to change the daily limit (no more than 4k of acetaminophen.
30-09-2007, 19:55
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