GABOB for growth hormone?

[DrStrange]

If you never heard of it, GABOB is not someone's name, it is actuallly aminohydroxybutyric acid. Claims are made that it is sort of a cross between GABA and GHB but without the sedative effects of GHB. Therefore no danger of it ever being called a date rape drug. The big deals are anti-anxiety and growth hormone and prolactin production boosting.

Anyone know of any studies or even experience of oral dosing resulting in growth hormone boost? So far, all studies I've found referenced are for i.v. use which is not so practical on a long term basis; at least not for me.

Here's some rant from an anti-aging newsletter I get:

Aminohydroxybutyric Acid - The alternative GHB

Aminohydroxybutyric acid is otherwise known as GABOB, Gamibetal or
Buxamin and is related to GABA and also to GHB.

This rarely found supplement has been in published literature since the
1960's, and its uses in Europe have been for its anti-anxiety,
anti-stress purposes and also for its anti-convulsion actions in Epilepsy.

What is very interesting is that since the 1980's it has been known
that Aminohydroxybutyric acid can increase growth hormone levels. One
study, (Melis GB et al: Dose related effects of gamma-amino beta-hydroxy
butyric acid [GABOB] infusion on growth hormone secretion in normal
women: J. Endocrinol. Invest., 1982 Mar-Apr;5(2):101-6) found that when
women were infused with 100 mg. over 20-minutes that there was a
significant rise in HGH levels over their controls. This helped back up an
earlier study, (Fioretti P. et al. Gamma-amino-beta-hydroxy butyric acid
stimulates Prolactin and growth hormone release in normal women. J. Clin.
Endocrinol. Metab. 1978 Dec;47(6):1336-40), that also suggested that 100
mg. of aminohydroxybutyric acid i.v. increased HGH and Prolactin
levels.

Significant improvements to HGH, Prolactin and cortisol levels have
also been noted in men who were injected with 300 mg. of
Aminohydroxybutyric acid, (Takahara J et al. Stimulatory effects of
gamma-aminohydroxybutyric acid [GABOB] on growth hormone, Prolactin and cortisol release in
man).

What makes all this significant is that these agonist (stimulatory)
effects of Aminohydroxybutyric acid are very similar to GHB, and whilst
the injectable versions have induced unconsciousness at dosages over 150
mg., it does not appear to do so when used orally, (this was the main
reason why GHB banned as it can induce unconsciousness when taken orally
and was used by nefarious males for date-rape).

Therefore, this is why we believe that as Aminohydroxybutyric acid is
related to GHB and shares many of its properties; it is in fact the
closest legal molecule/ alternative available.

There are no reported side effects at normal dosages. At high dosages
some slight drowsiness may occur, therefore caution is advised to be in
a safe environment, (i.e. not driving or operating machinery etc).

There are no specific contraindications listed, although concurrent use
with other GABA supplements and agonists (i.e. Valium) is not advised
and would be best considered only under a physician's guidance.

Dosages for anti-anxiety/ stress would be in the region of 250 mg. once
or twice daily. For epilepsy 500 mg. twice daily. For HGH release,
(whilst this does still remain “experimental” in oral form), in the region
of 500 mg. to 1000 mg. prior to bedtime.