Health - The schizophrenia ketamine challenge study debate

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Description: Protection of subjects in psychiatric research is an issue of considerable public and professional interest. Perhaps the most hotly debated issue concerns challenge study protocols where symptoms of illness are increased in a bioassay designed to gain knowledge of pathophysiology. Although widely used in biomedical research, the ethics of this application in mental illness research are contested. At issue is whether acute distress and lasting harm are caused without direct benefit in vulnerable subjects without valid informed consent. The ketamine challenge study in schizophrenia subjects is at the vortex of the current debate. This report presents background data on ketamine safety and a qualitative and quantitative analysis of data from all schizophrenia subjects in North American ketamine studies.

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