Does Effexor ruin it?

[shena]

SWIM has on several occasions tried mushrooms (2-4 g) and no reaction. Most recently, SWIM tried three caps of MDMA in a night and got nothing. SWIM has been taking a SNRI antidepressant, Effexor, for a year and wonders if it is that which is inhibiting her enjoyment. Depressants like weed and alcohol still work, as does DXM and Gravol... SWIM had been looking very much forward to her first MDMA experience and was sorely disappointed. Does anyone have any suggestions apart from going off the head meds? Just not an option. Your help is greatly appreciated!