Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News
Go Back   Drugs Forum > DRUG-FORUMS > Opiates & Opioids
Mark Forums Read
Register Tags

Notices

Opiates & Opioids Opiates & Opioids.

 
Thread Tools
  #1  
Old 15-10-2006, 02:42
Stiffy Stiffy is offline
Silver Member
 
Join Date: 12-10-2006
Male
Posts: 10
Stiffy is an unknown quantity at this point
Points: 42, Level: 1 Points: 42, Level: 1 Points: 42, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Promethazine tablets... (Help with opiates?)

I read somewhere in this forum that promethazine makes the opiates more potent in some way or another when taken together? Also, does this mean it just increases the effects or makes it more dangerous?

I have quite a bit of 25 mg promethazine tablets that SWIM could take in conjunction with hydrocodone syrup...

Last edited by Forthesevenlakes; 15-10-2006 at 04:02.
  #2  
Old 15-10-2006, 04:02
Forthesevenlakes Forthesevenlakes is offline
Account Awaiting Email Confirmation.
 
Join Date: 26-02-2006
Male
Posts: 2,071
Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.Forthesevenlakes really knows their shit.
Points: 2,192, Level: 7 Points: 2,192, Level: 7 Points: 2,192, Level: 7
Activity: 0% Activity: 0% Activity: 0%
Re: Promethazine tablets... (Help with opiates?)

please use the search engine, this topic has been covered before. If you're having trouble finding it on the forum try searching for "opiate potentiation", theres a copule potentiation threads in here. Please remember to use SWIM.
  #3  
Old 29-12-2008, 21:41
drug-bot drug-bot is offline
Account Awaiting Email Confirmation.
 
Join Date: 04-07-2008
28 y/o Male from United States
Posts: 459
drug-bot must live here.drug-bot must live here.drug-bot must live here.drug-bot must live here.drug-bot must live here.drug-bot must live here.drug-bot must live here.
Points: 1,405, Level: 5 Points: 1,405, Level: 5 Points: 1,405, Level: 5
Activity: 0% Activity: 0% Activity: 0%
does phenergan (promethazine) really potentiate opiates?

swim has a dozen or so phenergan's(promethazine) , 25mg, on hand and has heard various reports on the net that they can potentiate the effects of opiates (swims on 90mg methadone daily). does anyone have experience combining phenergan w/ any opiate? results, positive, negative, none? if it does work well to potentiate opiates any dose suggestions? please help by responding peace.
  #4  
Old 29-12-2008, 22:48
award11 award11 is offline
Silver Member
 
Join Date: 10-12-2008
41 y/o Male
Posts: 52
award11 is a decent psychonaut.
Points: 141, Level: 1 Points: 141, Level: 1 Points: 141, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Re: does phenergan (promethazine) really potentiate opiates?

In SWINs opinion, the phenegran will have no added recreational value at all. It is regularly prescribed in combination with opiates to take away from the nausea assosiated with certain medications. I do not foresee any positive or negative issues other than the phenegran possibly making you somewhat drousy and in my opinion, take away from the opiate feeling.
  #5  
Old 30-12-2008, 07:26
mbarnes0 mbarnes0 is offline
Silver Member
 
Join Date: 05-11-2008
25 y/o Male from United States
Posts: 247
mbarnes0 is captain of the psychonauts.mbarnes0 is captain of the psychonauts.
Points: 350, Level: 2 Points: 350, Level: 2 Points: 350, Level: 2
Activity: 0.1% Activity: 0.1% Activity: 0.1%
Re: does phenergan (promethazine) really potentiate opiates?

SWIM agrees with swiAward. SWIM has found through experience that the phenegran w/codeine syrup may help potentiate opiates, although this is most likely the combination of the codeine and the syrup itself containing a small amount of alcohol. SWIM doubts that the promethazine tabs will enhance SWIYs experience.
  #6  
Old 30-12-2008, 19:07
Richard_smoker Richard_smoker is offline
Account Awaiting Email Confirmation.
 
Join Date: 19-09-2005
38 y/o Male from United States
Posts: 1,239
Richard_smoker must mainline MedlineRichard_smoker must mainline MedlineRichard_smoker must mainline MedlineRichard_smoker must mainline MedlineRichard_smoker must mainline MedlineRichard_smoker must mainline MedlineRichard_smoker must mainline MedlineRichard_smoker must mainline MedlineRichard_smoker must mainline MedlineRichard_smoker must mainline MedlineRichard_smoker must mainline Medline
Points: 3,596, Level: 8 Points: 3,596, Level: 8 Points: 3,596, Level: 8
Activity: 0% Activity: 0% Activity: 0%
Re: does phenergan (promethazine) really potentiate opiates?

basically, phenergan has been said to make the effects of less-powerful opiates like codeine more similar to heroin by adding an element of drowsy sleepiness to the experience. as far as doing anything else, the only other opiate-friendly activity would be to prevent nausea. -DICK
  #7  
Old 04-01-2009, 17:39
Baltiland6.0 Baltiland6.0 is offline
Newbie
 
Join Date: 03-01-2009
Male from United States
Posts: 26
Baltiland6.0 is an unknown quantity at this point
Points: 6, Level: 1 Points: 6, Level: 1 Points: 6, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Re: does phenergan (promethazine) really potentiate opiates?

Swim would recomend taking 12.5mg's for the first time so you know you wont be too drowsy. Swim loves 25mg's occasionally with his methadone and when swim used to shoot H taking even 12.5mg's definetly helped with nausea and just made it feel a little better. Swim has actually I.V.'d Phenergen with dope with very good results. Just try it out, you got em' so if you dont like them just hold on to them till your really sick and are nauseaous and can use them for there prescribed use.
  #8  
Old 05-01-2009, 21:28
SouthSideK SouthSideK is offline
Newbie
 
Join Date: 05-01-2009
Male
Posts: 4
SouthSideK is an unknown quantity at this point
Points: 5, Level: 1 Points: 5, Level: 1 Points: 5, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Re: does phenergan (promethazine) really potentiate opiates?

SWIM was in the hospital for a long time and was on Dilaudid. They Dr's gave SWIM phenergan after SWIM's surgery and SWIM got an allergic reaction. The phenergan and Dilaudid made SWIM stop breathing. SWIM's wife had to keep SWIM up for several hours so SWIM would keep breathing.
  #9  
Old 06-01-2009, 03:10
static_vodka_420 static_vodka_420 is offline
Silver Member
 
Join Date: 25-07-2007
Female from United States
Posts: 218
static_vodka_420 is a decent psychonaut.static_vodka_420 is a decent psychonaut.
Points: 194, Level: 2 Points: 194, Level: 2 Points: 194, Level: 2
Activity: 0% Activity: 0% Activity: 0%
Re: does phenergan (promethazine) really potentiate opiates?

swim says promethazine only slightlly potentiates euphoria and has more of an effect on swims nod than anything obviouslly bringing it about sonner at a lower dose

swim prefers dipenhydramine and hydroxyzine for his opiate potentiation both seem to potentiate the euphoria more and the nod less and swim likes to enjoy his buzz not sleep it off

to all those swimmers be careful swims close friend recentlly dyed from a mixture of prescription narcotics... just remember it can happen to anyone, the same dose on a different day can have a vastlly diffferent effect depending on many variables suck as food consumed, unknown potentiators, spacage of doses, etc.
swims friend had a huge tolerance but he didnt know about his allergy to coconut cake or grapefruit juice potentiation so his normal dose was too much this time.. so swiys start out small and work ones way up

- swim-=
  #10  
Old 10-04-2009, 20:55
hamsterdam hamsterdam is offline
Silver Member
 
Join Date: 08-02-2009
Male from United States
Posts: 398
hamsterdam is a decent psychonaut.hamsterdam is a decent psychonaut.
Points: 488, Level: 3 Points: 488, Level: 3 Points: 488, Level: 3
Activity: 14.2% Activity: 14.2% Activity: 14.2%
Promethazine is a GREAT add-on to opiates

Before swim starts.. there's a warning for this..

It is highly recommended you cut your opiate dose by a QUARTER to a HALF for the first time you experiment with this. If you normally take 100mg of something, cut it to 50 - 75mg for the first time.

Taking promethazine with hydrocodone resulted in a much better high for SWIM. It has a slightly sedative effect, and it kills any nausea (SWIM actually doesn't mind puking at all, but the nausea leading up to it isn't enjoyable). It also reduces the itchies slightly, but for SWIM he still got plenty of enjoyable scratching. SWIM hasn't noticed that much of a synergy effect, just a much nicer, cleaner high. It even made him feel well enough to eat a couple pieces of bread to kill the hunger pangs. Normally he won't eat anything since any food induces more nausea and ruins the puking if there is any. But with promethazine, there was absolutely ZERO nausea throughout the entire night.

SWIM's dose for the night:
- 28.8mg hydrocodone (estimate)
- 25mg promethazine
- 400mg cimetidine
- 1 gram calcium carbonate
- 466.3mg APAP (estimate)

Another benefit is that it helps you stay asleep throughout the night.. since it is a mild sedative. No more waking up at 4 AM desperate to get off again.
  #11  
Old 11-04-2009, 21:47
trannyboy trannyboy is offline
Account Awaiting Email Confirmation.
 
Join Date: 05-04-2009
Male
Posts: 144
trannyboy is captain of the psychonauts.trannyboy is captain of the psychonauts.
Points: 192, Level: 2 Points: 192, Level: 2 Points: 192, Level: 2
Activity: 0% Activity: 0% Activity: 0%
Re: Promethazine is a GREAT add-on to opiates

Promethazine sounds like quite a medication but I wanted to mention that it is conterindictated is the acute porphyrias. I checked because I thought it might help me but I can't take it because of acute intermittent porphyria. So if you have any of the acute porphyrias be very careful and really you shouldn't take it at all in those cases unless it is absolutely needed in which cause only in hospital with heme available to stop the attack. Also it has to be injected very slowly, no more then 25mg per minute with a concentration of 25mg/ml as it can cause very serious side effects. Take care and have fun safely.

trannyboy
  #12  
Old 12-04-2009, 01:46
hamsterdam hamsterdam is offline
Silver Member
 
Join Date: 08-02-2009
Male from United States
Posts: 398
hamsterdam is a decent psychonaut.hamsterdam is a decent psychonaut.
Points: 488, Level: 3 Points: 488, Level: 3 Points: 488, Level: 3
Activity: 14.2% Activity: 14.2% Activity: 14.2%
Re: Promethazine is a GREAT add-on to opiates

No no no, this was a promethazine tablet.

Swim highly advises you do NOT inject promethazine, even if you have the ampule.

Google for phenergan levine

Don't screw around with that shit, you'd be safer off injecting heroin off the street.

There's also a promethazine suppository.. if that's your kinda thing. And as always.. you should be reading the label for all warnings/contraindications/interactions before taking any new medication.
  #13  
Old 12-04-2009, 01:57
trannyboy trannyboy is offline
Account Awaiting Email Confirmation.
 
Join Date: 05-04-2009
Male
Posts: 144
trannyboy is captain of the psychonauts.trannyboy is captain of the psychonauts.
Points: 192, Level: 2 Points: 192, Level: 2 Points: 192, Level: 2
Activity: 0% Activity: 0% Activity: 0%
Re: Promethazine is a GREAT add-on to opiates

The reason I mentioned porphyria is often the drug information sheet included with the prescription doesn't mention whether it is safe with porphyria. I agree that the dangers of injecting even an ampule of promethazine isn't too high to risk for anyone. The dangers and known complications in healthy people are frightening. My statement was in regards to injections in case it was available mixed with an opiate. However other ROA seem reasonably safe if you read the contraindictions and follow them to a T.

trannyboy

trannyboy added 1 Minutes and 15 Seconds later...

Opps I meant the dangers ARE too high not isn't too high to inject.

trannyboy

Last edited by trannyboy; 12-04-2009 at 01:57. Reason: Automerged Doublepost
  #14  
Old 12-04-2009, 02:01
hamsterdam hamsterdam is offline
Silver Member
 
Join Date: 08-02-2009
Male from United States
Posts: 398
hamsterdam is a decent psychonaut.hamsterdam is a decent psychonaut.
Points: 488, Level: 3 Points: 488, Level: 3 Points: 488, Level: 3
Activity: 14.2% Activity: 14.2% Activity: 14.2%
Re: Promethazine is a GREAT add-on to opiates

Not to mention there's no real benefit to shooting up promethazine if you're after the synergy/anti-emetic effects.

Just take the tablet an hour before and it'll be in your system. It has a very long half life.
  #15  
Old 12-04-2009, 04:04
trannyboy trannyboy is offline
Account Awaiting Email Confirmation.
 
Join Date: 05-04-2009
Male
Posts: 144
trannyboy is captain of the psychonauts.trannyboy is captain of the psychonauts.
Points: 192, Level: 2 Points: 192, Level: 2 Points: 192, Level: 2
Activity: 0% Activity: 0% Activity: 0%
Re: Promethazine is a GREAT add-on to opiates

Thanks for the info Hamsterdam. I am sure it will prove useful to many people on this forum. You seem to be very knowledgable on this medication.

trannyboy
  #16  
Old 12-04-2009, 04:34
pinksox pinksox is offline
Palladium Member
 
Join Date: 11-02-2009
Female from United States
Posts: 665
pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.pinksox really knows their shit.
Points: 1,472, Level: 5 Points: 1,472, Level: 5 Points: 1,472, Level: 5
Activity: 5.6% Activity: 5.6% Activity: 5.6%
Re: Promethazine is a GREAT add-on to opiates

Quote:
Also it has to be injected very slowly, no more then 25mg per minute with a concentration of 25mg/ml as it can cause very serious side effects.
The SwiOP is referring to the PO(oral) dose of promethazine...which IS accurate at 25mg. there is actually a black box label on promethazine now as they reformulated a few years back and the standard IV dose is now 6.25-to-12.5mg. 25mg of IV promethazine will now knock a grown man out cold for hours. And SWIM does mean hours...(and that's NOT with concurrent opiate administration).

SWIM would recommend as the OP said cutting their opie dose by 1/3 to 1/2 with 25mg promethazone PO OR halfing the oral promethazine to 12.5mg PO and cutting their dose by 1/4...at least until they're familiar with how promethazine will affect them with concurrent opiate use.
  #17  
Old 12-04-2009, 04:38
hamsterdam hamsterdam is offline
Silver Member
 
Join Date: 08-02-2009
Male from United States
Posts: 398
hamsterdam is a decent psychonaut.hamsterdam is a decent psychonaut.
Points: 488, Level: 3 Points: 488, Level: 3 Points: 488, Level: 3
Activity: 14.2% Activity: 14.2% Activity: 14.2%
Re: Promethazine is a GREAT add-on to opiates

Also, just an FYI. Oral promethazine has really shitty bioavailability.. the suppository (And if you do intend on sticking this up your ass.. please do get the proper suppository and don't try to do it with the tablet!) may have better bioavailability.. just something to keep in mind since both are common routes of administration.

In the UK you can also get 20mg promethazine tablets OTC (you lucky bastards, not having to bother w/ a dr appt for trivial stuff like this ). It's marketed as a sleep aid (since it is a mild sedative). So you can pick that have a nice cwed codeine/apap + promethazine combo.

Last edited by hamsterdam; 12-04-2009 at 04:45.
  #18  
Old 12-04-2009, 08:49
trannyboy trannyboy is offline
Account Awaiting Email Confirmation.
 
Join Date: 05-04-2009
Male
Posts: 144
trannyboy is captain of the psychonauts.trannyboy is captain of the psychonauts.
Points: 192, Level: 2 Points: 192, Level: 2 Points: 192, Level: 2
Activity: 0% Activity: 0% Activity: 0%
Re: Promethazine is a GREAT add-on to opiates

You really have an issue with misunderstanding me. The original poster mentioned dosage, I only mentioned concentration and injection rate as stated by wiki. As for self imcrimination, it is kind of hard to do that with an admittedly legal substance that I didn't mention me taking. I said I was thinking about but it was conterindictated for me and others with acute porphyrias. Why are you bothering to read my posts if you can't be bothered to actually read it.

trannyboy

trannyboy added 31 Minutes and 54 Seconds later...

My last post was in reference to pinkfox and not hamsterdam. Sorry should have been more specific.

trannyboy

trannyboy added 17 Minutes and 4 Seconds later...

In mentioning rate of administration and concentration, I was not in anyway suggesting that someone use this medication by route of injection. Nor am I suggesting a dosage as that should be determined between the user and their doctor. I am not experienced with this medication at all and the only information I have is from wiki (rate of injection and concentration) and a few medical journals (porphyria risk). Since the original poster appears knowledgable in this subject I would suggest taking his information as a starting point, do some research yourself and talk to your doctor about your conclusions. Since pinkfox has stated different dosages, I would further encourage you to do your own research and speak to your doctor. Please remember though that I have very little knowledge of this medication beyond it's dangers in acute porphyrias and nothing I say on this subject should be taken as fact besides the porphyria risk but then again anyone with an acute porphyria will understand my concerns.

trannyboy

Last edited by trannyboy; 12-04-2009 at 08:49. Reason: Automerged Doublepost
  #19  
Old 13-01-2013, 16:42
rodentsaurus rodentsaurus is offline
Silver Member
 
Join Date: 12-01-2013
51 y/o Male from United States
Posts: 2
rodentsaurus is an unknown quantity at this point
Points: 5, Level: 1 Points: 5, Level: 1 Points: 5, Level: 1
Activity: 0.3% Activity: 0.3% Activity: 0.3%
Re: does phenergan (promethazine) really potentiate opiates?

HI All;

I know this thread is a bit OLD, but I figured that it's never too late for some first-hand experience.

Back in 2003, I was treated to the dual whammy of getting away from OxyContin, and a case of appendicitis, at the same time.
To say I was miserable is an understatment of epic proportions; between the abstinence syndrome, pain, fever, nausea, headache, etc., extinction didn't seem like such a bad way to go at the time.

My ER doctor was a very compassionate man, and decided to try to make me comfortable, at least as best he could, and sent a nurse over to my tortured carcass with a syringe. She explained that the doctor had ordered an injection of demerol and phenergan to help keep me comfortable, until tests could be run, and I could be admitted for possible surgery.

This made me very agitated, as I'd had a BAAAAD experience with demerol several years back, owing to two of its metabolites, the infamous normeperidine, and normeperidinic acid, and I initially refused the injection.
My ex-wife was with me at the time, and she convinced me to accept the injection, in hopes that I would feel better, at least temporarily. Well, what happened next was both completely unexpected, and completely unique in my experience; as I'd had Demerol before for pain, and thought nothing of it, I was completely unprepared for the unbelieveable rush that passed over my body. Think somebody shoving a Saturn V up your behind, then reaching back to the business end of the rocket with a lighter, and setting the monster off; yep, that was me, complete with Vangelis' "Ask the Mountains" playing in the background.

Despite my substantial experience with prescribed opiates for a birth defect in my spine, and the accompanying tolerance, the combination of Demerol (a worthless medication anyway, IMHO) and Phenergan, resulted in a potentiation of the former to the point that it was nothing short of "psychoactive", rather than simply analgesic, or slightly euphorogenic.

I know that this thread started with a question about the accuracy of statements implying that phenergan was an opiate potentiator, and the answer, in my experience, is ABSOLUTELY! There is no if, and, or butt about it. On the down side, the incredible feeling produced by the mixture was very short lived, and when it passed, it did so very quickly, and very abruptly, replaced by a marked feeling of anxiety, and agitation.
This may have been due to one of the two metabolites I mentioned, but there is no way at this time to be certain.
Also, it seems to be accepted in the pain management community that Demerol and codeine respond best to phenergan potentiation, whilst the more efficacious medications show a less marked potentiation.

Finally, to those out there who are thinking of just charging in and shooting up, I say DON'T DO IT! Unless you are seriously tolerant (can you take a 64 mg hit of Dilaudid, I.V., in one blast? No? I didn't think so - stay away from potentiation!), you run the risk of blasting yourself right into resperatory depression, and the life-ending coma that will follow it.

Remember, opiate potentiators, by definition, increase the activity of the medication on ALL of the body's systems, so if the analgesic effect is increased, so will the effects of respiratory depression, slowed breathing, and CNS depression. It's an incredible risk, for an essentially worthless return.

It's not worth it.

Peace, and good health to all

Skweek

Post Quality Evaluations:
Thanks for the very descriptive personal experience, as well as the very welcome addition about risk.

Last edited by Smeg; 24-07-2013 at 04:49. Reason: Paragraphing and line-spacing to facilitate reading.
  #20  
Old 13-01-2013, 18:31
RoboCodeine7610 RoboCodeine7610 is offline
Silver Member
 
Join Date: 30-05-2008
Male from Spain
Posts: 2,080
RoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPAC
Points: 3,391, Level: 8 Points: 3,391, Level: 8 Points: 3,391, Level: 8
Activity: 2.7% Activity: 2.7% Activity: 2.7%
Re: does phenergan (promethazine) really potentiate opiates?

Quote:
I know that this thread started with a question about the accuracy of statements implying that phenergan was an opiate potentiator, and the answer, in my experience, is ABSOLUTELY! There is no if, and, or butt about it. On the down side, the incredible feeling produced by the mixture was very short lived, and when it passed, it did so very quickly, and very abruptly, replaced by a marked feeling of anxiety, and agitation.
Had you ever taken the pethidine intravenously before?A fast, euphoric onset of action followed by a quick and sudden comedown is consistent with IV administration of any opiate.I believe this is a more likely explanation, as there's no pharmacological reason to believe promethazine would potentiate any opiate, save for increased sedation, other than possibly codeine.

Robo
  #21  
Old 14-01-2013, 17:07
rodentsaurus rodentsaurus is offline
Silver Member
 
Join Date: 12-01-2013
51 y/o Male from United States
Posts: 2
rodentsaurus is an unknown quantity at this point
Points: 5, Level: 1 Points: 5, Level: 1 Points: 5, Level: 1
Activity: 0.3% Activity: 0.3% Activity: 0.3%
Re: does phenergan (promethazine) really potentiate opiates?

Quote:
Originally Posted by RoboCodeine7610 View Post
Had you ever taken the pethidine intravenously before?A fast, euphoric onset of action followed by a quick and sudden comedown is consistent with IV administration of any opiate.I believe this is a more likely explanation, as there's no pharmacological reason to believe promethazine would potentiate any opiate, save for increased sedation, other than possibly codeine.

Robo
Hi Robo:

Yes, I have; before, and afterward, and as I wrote, there was no comparison. But again, Demerol and codeine are the two opiates (I think demerol is possibly best described as an opioid, not opiate, but that's just my opinion) mentioned to be most affected when combined with the phenergan. I have not tried the potentiation again with any other medication, as I knew nothing of it until I got it by default in my local ER, and my only use of opiates is by prescription.

Skweek
  #22  
Old 14-01-2013, 21:30
RoboCodeine7610 RoboCodeine7610 is offline
Silver Member
 
Join Date: 30-05-2008
Male from Spain
Posts: 2,080
RoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPACRoboCodeine7610 must think in IUPAC
Points: 3,391, Level: 8 Points: 3,391, Level: 8 Points: 3,391, Level: 8
Activity: 2.7% Activity: 2.7% Activity: 2.7%
Re: does phenergan (promethazine) really potentiate opiates?

Quote:
Yes, I have; before, and afterward, and as I wrote, there was no comparison. But again, Demerol and codeine are the two opiates (I think demerol is possibly best described as an opioid, not opiate, but that's just my opinion) mentioned to be most affected when combined with the phenergan. I have not tried the potentiation again with any other medication, as I knew nothing of it until I got it by default in my local ER, and my only use of opiates is by prescription.
Very interesting report then.It'd be even better if you could find some pharmacological mechanism to back up your claim, as drug experience can be very subjective.
  #23  
Old 18-06-2013, 08:12
malusdesmodus malusdesmodus is offline
Newbie
 
Join Date: 14-10-2012
37 y/o Male from Earth
Posts: 6
malusdesmodus is an unknown quantity at this point
Points: 5, Level: 1 Points: 5, Level: 1 Points: 5, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Re: does phenergan (promethazine) really potentiate opiates?

Something to add to this, if only to update a thread that is (relatively) already recent.

Promethazine does not have ANY effect whatsoever really beyond reducing the nausea aspect associated with an opiate.

I am not a recreational user, but I like to be informed of what I am/have taken.

A severe back injury in '07 set me back several years (being stupid trying to move a LaserJet 8200DTN with the 4th tray option is not something anyone should do by themselves, I did, and even with 7 years of Powerlifting background (with guys like what you see in Westside Barbell in Columbus or at the IPA meets when they were still coexistening with the Arnold Classic) is really fucking stupid on my part, so don't repeat my dumbass mistake....).

At multiple times I have been on prescription doses of just about every Opiate on the market, from Oxycodone, to Oxymorphone, to Hydromorphone, Hydrocodone, Fentanyl Duragesic patches (multiple versions), to Morphine Sulfate SR/ER/IR), and even Methadone (not as part of a detox, but as a pain killer after my hospital damn near killed me on liquid Dilaudid).

I can say with verified knowledge that some of the potentiation options with the forumulas around that use the 45 minute recipe with DXM, Tagament, Benadryl, Aleve, etc (it's the very first link if you google Opiate potentiation) does work, effectively, both for duration/relation of pain and tolerance.

For me it is something that becomes for obvious reasons less effective over time. Three times since the initial episode I have weened off opiates completely for several months, including Fentanyl patches and Methadone (which for some wonderfully shitty ass reason had a 5 month half life for me when down to 5mg a day, fucking murder if you ask me, I have no idea how a Heroin addict could deal with it).

I do not, have not, and never will abuse or use recreationally, so I can't say if this fact is true for all Opiates/Narcotics, especially those that are schedule I.

But FWIW, I figured I'd share this just because I know sometimes when you read these posts and they're six years old, sometimes you feel a little more relieved if the information is new(ish) and/or updated.
  #24  
Old 18-06-2013, 23:49
dripdiddydrip dripdiddydrip is offline
Account Awaiting Email Confirmation.
 
Join Date: 05-04-2013
Male from United Kingdom
Posts: 37
dripdiddydrip should urgently read the rules & received reputation comments.
Re: does phenergan (promethazine) really potentiate opiates?

It's curious to me that promethazine's antipsychotic properties, partial blocking of the effects of dopamine, a negative effect on the high, some even claiming that it is an inducer of CYP2D6. In my pink elephant's experiences promethazine has decreased the high and just made him sleepy, with taking it an hour before before, as well as taking it an hour after taking codeine. For my pink elephant, alcohol, alprazolam and strangely ranitidine and chocolate are sure bets in increasing the high.
  #25  
Old 24-07-2013, 04:34
Demon463 Demon463 is offline
Newbie
 
Join Date: 27-10-2012
28 y/o Male from Australia
Posts: 11
Demon463 is an unknown quantity at this point
Points: 18, Level: 1 Points: 18, Level: 1 Points: 18, Level: 1
Activity: 0.1% Activity: 0.1% Activity: 0.1%
Re: does phenergan (promethazine) really potentiate opiates?

for me phenergan definately makes tramadol alot better and more trippy. I much prefer tramadol to codeine, and because tramadol is a stimulating drug in a way I don't get too tired from the phenergan either. Just a little noddy sometimes lol, luv it!!

Demon463 added 12 Minutes and 31 Seconds later...

ohh yeah, I am and have been heavy drug abuser for years. So I know that it definately potentiates things.

But I suppose everybody reacts differently to all the different opiates and synthetic opiates out there. And I wud imagine that promethazine would react differently with different opiates or opioids. I know tramadol is a synthetic opiate, which is supposed to be alot weaker than morphine. But by adding the promethazine I think it makes tramadol just as good as oxycontin. Only problem is u cant mix up tramadol pills.

Strangely though I find that phenergan doesn't do much to potentiate oxy's, but it works really well for me with poppy seed tea. I don't even bother with codeine these days. It just doesn't work at all for yah afta a while. And makes u wanna spew if u drinking cold water extraction hahaha

Last edited by Demon463; 24-07-2013 at 04:34. Reason: Automerged Doublepost

Share this on:

Tags
antihistamine, drowsy antihistamine, opiate potentiation, phenergan, potentiating opiates, promethazine, promethazine and codeine, promethazine and opiates, promethazine recreational

Thread Tools


Similar Threads
Thread Thread Starter Forum Replies Last Post
Experiences - Pregabalin DOES potentiate Opiates. (Experience inside) OpiFrogJewNoMe Opiates & Opioids 3 26-08-2013 03:44
Drug info - How to potentiate opiates using 1-3 beers cybergenesis Opiates & Opioids 7 11-07-2011 10:12
Combinations - Does combining opiates potentiate each other? diffs Opiates & Opioids 2 02-10-2010 01:28

» New Threads
Need advice. HOw and when do you...
Last post by Cwb20022
3 Replies, 96 Views
I tried but it rough fear the...
Last post by tcttuck
51 Replies, 2,892 Views
Painful spot but no redness after...
Last post by BellTower72
4 Replies, 155 Views
MDMA and temporomandibular joint...
Last post by Champazzo
6 Replies, 297 Views
TMJ and rolling
Last post by Champazzo
2 Replies, 60 Views
Please help - Need support -...
Last post by AKA_freckles
7 Replies, 299 Views
Lets say it takes an hour for tea...
Last post by ldawg616
12 Replies, 322 Views
Kratom Tips and tricks
Last post by Replicator
2 Replies, 115 Views
Could MDMA/MDA Possibly solve the...
Last post by Nosferatus
1 Replies, 42 Views
What are your experiences with...
Last post by AltrdPercption
3 Replies, 57 Views
» New Wiki Articles
GHB
NET

Sitelinks: Information:

All times are GMT +1. The time now is 04:22.


Copyright: SIN Foundation 2003 - 2014, All rights reserved