If I wanted the shortest duration then it seems like I would do one big dose all at once (spread over whatever routes of administration happen to be preferable.)
But if I wanted to balance duration vs. intensity of effects... Well I would try to time it out so as to overlap the peak effects of the first dose with the come-up of the 2nd dose. Then as the 1st dose kind of plateaus I'd hopefully be peaking on the 2nd dose. I haven't done MXE
in a while but it used to take me roughly 2 hours (maybe a bit more) to hit the peak. So 45 minutes or 1 hour before peaking I would be sure to have dosed a 2nd time. In this way, you get the feeling of 2 huge waves hitting you during the trip.
An alternative leisure route I used to follow was to maximize the "floaty" feeling of MXE for as long as possible and end with a bang:
1. Insufflate a small line (5-15 mg depending on tolerance) every fifteen minutes until "adequately dissociated".
2. To determine adequate level of dissociation, I'd do a test to see how many push-ups I could perform. If I felt any pain in my arms, I would go back and do two lines or so. Do push-up test again, if I have to stop for anything less than muscle exhaustion
then I would have to do another line.
3. Measure out a moderate/large size dose (40-60 mg maybe, it's pretty subjective and based on tolerance) and administer it sublingually.
4. M-hole. Haha, I would just love the feeling of thinking I was really
messed up and then letting the big sublingual dose hit all at once in comparison to the gentle come-up of small intranasal
bumps. It would be a "you ain't seen nothing yet" kind of moment.
As far as dosing methods go, I think inducing dry mouth (from smoking cannabis
or synthetic variants) and then administering MXE sublingually worked the best for me. There would hardly be any saliva to wash away the chemical and it allowed for uninterrupted absorption for as long as I could keep my tongue steady. It would be a heap of MXE resting on the lightly moistened surface of the tongue/mouth. Ahh, sublime. By far I did the majority of my MXE intranasally but that was probably because I developed some odd nose-drug
fetish early on. There was something about the inhalation, slight twinge of discomfort, then the rush as I tilted my head back and let the dopamine
surge happen. Overall I think sublingual dosing is a tad more effective.
Rectal dosing was something I played with for a while but was never altogether impressed given how much work it took to prepare the implements and how hard it would be to redose.