is a Serotonin
, Norepinephrine, and Dopamine
Release Agent (SNDRA). The effects of Release Agents (RAs) like amphetamine, methamphetamine
, and MDMA
can be blocked by Reuptake Inhibitors (RIs) such as Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), Norepinephrine-Dopamine Reuptake Inhibitors (NDRIs), and Norepinephrine Reuptake Inhibitors (NRIs). The blockade correlates selectively based on which neurotransmitter
is being affected. So for example, an SSRI
will only block the serotonergic effects of amphetamine.
Despite the fact that amphetamine very, very mildly releases serotonin, it does so at a negligible level (at a rate nearly 150x less than dopamine release, and 450x less than norepinephrine release). Serotonin does not really contribute to amphetamine's effects at all, and I mean at ALL. The same applies to methamphetamine, which although is 2x as potent as a serotonin releaser as amphetamine, is still quite negligible. Norepinephrine does not contribute to the positive effects of the drug
hardly at all (ie., euphoria
, confidence, sociability, motivation, etc). In fact it'd likely be better if there weren't any norepinephrine release as there'd be less anorexia, insomnia, tweakiness, and anxiety. Dopamine is the seat of the euphoria of amphetamine and just about every other drug that "makes you feel good", including alcohol
, MDMA, cocaine
, and so forth.
In accordance with the above, SSRIs, SNRIs, NRIs, and TCAs will not directly block the positive effects of amphetamine. The sole NDRI
) will slightly block the positive effects, but not very much as it's a rather weak dopamine reuptake inhibitor. The reason you're experiencing diminished effects is likely because serotonin suppresses dopamine in many areas, both directly via downstream inhibition by action on 5-HT receptors (especially the 5-HT2C receptor), and indirectly via enhanced prolactin release (prolactin also directly suppresses dopamine). Ironically these so-called "antidepressants
" are actually quite dysphoric. They prevent both positive and negative emotion. More like emotional anesthetics
if you ask me. I remember I got restless legs syndrome (RLS) from an SSRI once (RLS is caused by too little dopamine). Contrary to popular belief, more serotonin generally does not lead to more happiness, perhaps with the sole true exception being MDMA.