Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News
Go Back   Drugs Forum > DRUG-FORUMS > Dissociatives > Ketamine
Mark Forums Read
Register Tags

Notices

 
Thread Tools
  #1  
Old 01-04-2012, 19:52
Xanahalf Xanahalf is offline
Silver Member
 
Join Date: 21-06-2011
Male from Canada
Posts: 205
Xanahalf is a decent psychonaut.Xanahalf is a decent psychonaut.
Points: 167, Level: 2 Points: 167, Level: 2 Points: 167, Level: 2
Activity: 0.6% Activity: 0.6% Activity: 0.6%
Ketamine grapefruit juice potentiation

SWIM has heard plenty of talk about grapefruit juice (GFJ) potentiating opiates but very little talk about its effect on ketamine. I'm fairly certain ketamine is broken down by the same P460 CYP3A4 enzyme's that opiates are so it should work. CYP3A4 is what turns awesome ketamine into awful norketamine. Inhibiting the enzyme should lead to both increased peak and longer duration, likely with a more pronounced effect on duration.

SWIM has not tried this and probably wont be able to for a little while but will post here when he can. I have seen one or two other threads on this but all old and with no actual experiences. One study i read somewhere talked about potentiating ketamine in rats but i forget where i read it...

Anyway any info, particularly first hand experiences, on the effectiveness of this potentiation would be much appreciated!
  #2  
Old 01-04-2012, 22:33
ianzombie ianzombie is offline
Platinum Member & Advisor
 
Join Date: 12-06-2007
38 y/o Male from Ireland
Posts: 6,443
Blog Entries: 3
ianzombie is a true resource and beyond reputeianzombie is a true resource and beyond reputeianzombie is a true resource and beyond reputeianzombie is a true resource and beyond reputeianzombie is a true resource and beyond reputeianzombie is a true resource and beyond reputeianzombie is a true resource and beyond reputeianzombie is a true resource and beyond reputeianzombie is a true resource and beyond reputeianzombie is a true resource and beyond reputeianzombie is a true resource and beyond repute
Points: 19,530, Level: 20 Points: 19,530, Level: 20 Points: 19,530, Level: 20
Activity: 100.0% Activity: 100.0% Activity: 100.0%
Re: Ketamine grapefruit juice potentiation

Here you go Ketamine and grapefruit juice
  #3  
Old 03-04-2012, 01:40
Xanahalf Xanahalf is offline
Silver Member
 
Join Date: 21-06-2011
Male from Canada
Posts: 205
Xanahalf is a decent psychonaut.Xanahalf is a decent psychonaut.
Points: 167, Level: 2 Points: 167, Level: 2 Points: 167, Level: 2
Activity: 0.6% Activity: 0.6% Activity: 0.6%
Re: Ketamine grapefruit juice potentiation

thx for the link, not sure why i didnt see that thread earlier!

For anyone too lazy to read through that thread: Grapefruit juice does indeed potentiate ketamine but ONLY when taken orally. GFJ only has an effect on the enzymes in the intestines, not in the liver. So if you snort or IM your ketamine (as nearly everybody does), GFJ will have no effect. If you snort a ton of ketamine you will likely end up swallowing a decent amount of it and the GFJ will make a difference there. Oral ketamine sucks generally but maybe with GFJ could be a little better.
  #4  
Old 04-04-2012, 21:22
Insomniacsdream Insomniacsdream is offline
Silver Member
 
Join Date: 20-08-2008
33 y/o Male from United Kingdom
Posts: 248
Insomniacsdream is learning how to become a psychonaut.
Points: 215, Level: 2 Points: 215, Level: 2 Points: 215, Level: 2
Activity: 2.6% Activity: 2.6% Activity: 2.6%
Re: Ketamine grapefruit juice potentiation

Oral ketamine is more anethetising and less usually regarded as pleasent. Also acidic drinks make K-pains far worse. If your K needs potentiating do a bit more.

Share this on:

Tags
grapefruit juice, ketamine, potentiation

Thread Tools


Similar Threads
Thread Thread Starter Forum Replies Last Post
Combinations - Ketamine and grapefruit juice Tarkovsky Ketamine 46 26-01-2013 02:53
Ketamine Beltane Drug Articles 36 31-12-2012 10:54
Drug info - Ketamine Guide 0utrider Ketamine 6 18-01-2012 22:47
Ketamine als partydrug R3direct Diverse drugs 2 26-02-2008 02:54
Ketamine and Naltrexone: Dissociation and Potentiation Forthesevenlakes Dissociatives 0 18-07-2006 06:03

» New Threads
Inspire
Last post by bignose1
0 Replies, 1 Views
My phenibut trials. Non-responder?
Last post by batman12
12 Replies, 382 Views
Codeine Vs Tramadol
Last post by Trying Again
3 Replies, 64 Views
ive finally jumped from 20 year...
Last post by charliecat
159 Replies, 7,584 Views
Lucky Australia, we still have the...
Last post by Trying Again
4 Replies, 80 Views
My goat got methylone not MDMA and...
Last post by oldsexygoat
8 Replies, 373 Views
Eating Disorders & Addictions
Last post by Trying Again
13 Replies, 540 Views
Guidance for managment of GBL and...
Last post by antimatt3r
1 Replies, 6,382 Views
Anyone pass a lab test 48-55 hours...
Last post by dugi187
9 Replies, 404 Views
THJ-018 info
Last post by antimatt3r
11 Replies, 4,370 Views
» New Wiki Articles

Sitelinks: Information:

All times are GMT +1. The time now is 14:35.


Copyright: SIN Foundation 2003 - 2014, All rights reserved