Hi folks, Swim is a regular user of codeine who has recently discovered a way to potentiate codeine that he has not read about before.
Usually Swim takes some promethazine (say 25mg to 50mg) about half an hour before ingesting the codeine (preferably on an empty stomach but today and yesterday he also took about 2mg of loperamide (immodium) approximately one hour before the codeine and wow! The results were wonderful, it really enhanced the experience.
Of course, this is probably not particularly wise to do all that often as constipation isn't that much fun.
Swim has a large amount of loperamide around that he's been meaning to experiment with solo, like an idiot, but has recently gotten hold of a decent amount of T3's. He will experiment with this and get back. It makes sense that it would potentiate too.
Swim also has huge amounts of tramadol, and uses with pot (at different times, because the two sadly do not work together well) as his main two drugs.
Swim theorizes tramadol + loperamide as having a good effect, and tramadol has not been the same for swim for about a year, it got really boring, lost the euphoria/sedation almost all the time.
Swim says 4mg loperamide made his tramadol much more physically sedating, his breathing was noticeably deeper and slower. Stronger CNS depression, but at the same time, less euphoria/contentment, but that could just be him.
This could work as a potentiator because even though Loperamide doesn't cross the bbb it does still bind to OTHER opiate receptors in the body, if most of the Gut receptors are full then in theory less codeine would fill gut receptors and would be able to fill more of the Brain ones. a similar idea was given by a guy talking about trying Loperamide to potentiate an endorphin rush.... it sounds possible....
DXM seems to be a better potentiator, but a little loperamide seems to work as well.. 1 loperamide, 1-2 dxm (max 60mg) and a lil GFJ makes a good potentatiors stack (even though GFJ is not good for potentiating codeine)
Swim has recently given up on most potentiators. Swim says that he just can't be sure if they are working, and it really drives Swim nuts taking so many things and still feeling like it does not help. Swim sometimes is almost sure that he is getting less euphoria when he takes potentiators.
Swim takes GFJ, Quercetin, Calcium Carbonate, Naproxen, and many more Swim can't think of. Swim will stop using them all for a long time, and start doing more in-depth experiements with them all after a bit.
Anyways, back on loperamide, Swim will test loperamide more often with opiates. Swim has high hopes ready some other posts here.
all placebo effect if anything. immodium does not cross the BBB. ive never tried to get high off it because i think that is so s*ck. trying to get high off otc anti-diarhhea pills, doesnt get any more pathetic than that.
what it can do, however, is in large doses it can alleviate minor opiate withdrawal. and it doesnt just get rid of the runs...it helps with everything. if youre ever in a situation where you have a very small dependence and experience hot/cold sensations, minor achiness and fatigue--take at least 12mg+ (6 pills) and wait about 1:30 to 2 hours. it should almost entirely get rid of the physical symptoms. the more you take the better probably but you also want to be able to sh*t sometime in the near future so dont overdo it. if you 12-16mg doesnt help much than up the dose. read stories of people wiyh bad opiate withdrawal, taking 150mg of loperamide with a benzo and literally destroying all symptoms.
Sportsguy, nobody's saying that loperamide gets you high, we're suggesting that it may potentiate codeine. Swim stumbled across this accidentally recently when he had gastro and took some codeine for fun. Read Stephenwolf's post above - he has a very viable theory on the subject.
Swim posted this a while back in other threads, but the loperamide, when mixed with other opioids, VERY noticeably increases CNS depression and slows breathing. Opioids tested with include codeine, hydrocodone, and tramadol.
Definately something to keep an eye out for.
We don't need someone dying because they mixed the two and had too much overall.
Hi folks, Swim is a regular user of codeine who has recently discovered a way to potentiate codeine that he has not read about before.
Usually Swim takes some promethazine (say 25mg to 50mg) about half an hour before ingesting the codeine (preferably on an empty stomach but today and yesterday he also took about 2mg of loperamide (immodium) approximately one hour before the codeine and wow! The results were wonderful, it really enhanced the experience.
Of course, this is probably not particularly wise to do all that often as constipation isn't that much fun.
I was under the impression that Loperamide, although a form of Opioid, does not cross the blood-brain barrier, and theoretically should make no difference to the effect of SWIY's Codeine use.
Although - I did read on www.opioids.com (a site I personally believe to be very inaccurate) that Loperamide may compliment the effects of Codeine.
There's a thread on DF about this, you could try searching. Was a hefty thread tho!
EDIT: Shoulda read the whole thread, lol. Stephenwolf's theory may well be plausible, although I'm not aware of gut receptors, but I'm not a medical professional... All I know is it does not cross the BBB, and as far as I was aware, would not potentiate Codeine.
a couple days ago SWIM saw SWIT's post and decided to give it a try, so he did a CWE with 160mg of codeine (probably yielded about 135mg) and took 4mg of loperamide 20 minutes before taking the codeine and noticed absolutely no change at all. in SWIM's opinion it makes no difference at all (exept with the constipation).
Loperamide only increases CNS effects, including physical sedation. This is not a positve, really, and gut motility goes all to hell. Constipation for next few days at least.
This is in regards to decent doses, above 10+mg.
Anything lower than 8mg will not have a noticeable effect.
There really is no point in adding loperamide unless you want to suffocate. Swim experimented with it plenty.
Swim combined up to 20+mg solo and with other opioids. Same thing with all, CNS sedation. Read: No euphoria or otherwise POSITIVE benefit.
My fox's best guess to the respiritory depression is that loperamide has a higher affinity for delta opiate receptors in the gut than any other opiate receptor. This would mean that the opiates will not bind to delta receptors but will bind to other receptors in the body. The mu2 receptor is believed to be chiefly involved with respiritory depression. My fox believes that the more opiates floating around in the blood stream will bind to the mu receptors and perhaps with greater affinity for mu2 than others, leading to this respiritory depression.
This does not sound advisable and caution should be exercised if any future experimentations are to take place.
This could work as a potentiator because even though Loperamide doesn't cross the bbb it does still bind to OTHER opiate receptors in the body, if most of the Gut receptors are full then in theory less codeine would fill gut receptors and would be able to fill more of the Brain ones. a similar idea was given by a guy talking about trying Loperamide to potentiate an endorphin rush.... it sounds possible....
It make sense. My friend took 30 mg of codeine for morphine withdrawal treatment and then took 4 mg of loperamide and the effect was definitely much stronger. He told me when cold turkying 30 mg of codeine does not give him any euphoria/opiate buzz, just solv the the worst body pain, but after loperamide the effect of codeine was notably stronger. Not any buzz but all cold turkey simptomes magically dissapeared.
Loperamide only increases CNS effects, including physical sedation. This is not a positve, really, and gut motility goes all to hell. Constipation for next few days at least.
This is in regards to decent doses, above 10+mg.
Anything lower than 8mg will not have a noticeable effect.
There really is no point in adding loperamide unless you want to suffocate. Swim experimented with it plenty.
Swim combined up to 20+mg solo and with other opioids. Same thing with all, CNS sedation. Read: No euphoria or otherwise POSITIVE benefit.
I agree, my friend reported not any increase of euphoria after both loperamide and loperamide+codeine dose. But he has found loperamide very helpful during cold turkey. It stops diarrhoea and also helps with pains and insomnia. But it seems to him, that it will not work for heroine or any strong opiate users. He used maximally 60 mg of morphine daily. I hope there will not be some idiot who will OD by loperamide resulting in loperamide OTC ban!
Last edited by stryke; 16-08-2011 at 22:22.
Reason: Automerged Doublepost
hi guys ..quick question...after a long long time off any opiate opiod..i took a day off today and hell,i had 500 mg of trams plus.100 mg of diazepam...as the body is not used im experiencing a quite enjoyable feeling,even though dont recomend it..my question is,after reading your post here,would at this time any immodium dose make things more enjoyable,or dangerous?you see im having a particularly bad shitty day and well...for a day,i want to sent all to hell..just not without knowledge from you guys experience...
My best friend, uses often codeine recreationally. He has never noticed any euphoria below 100 mgs, and he has a moderate tolerance (let's say codeine twice a week).
Anyway, today he had only 70 mgs, so after CWE, remains with 60 mgs. He wanted to check if loperamide (Immodium) potentiates opiates. An hour before he consumed 10 mg loperamide, empty stomach. The 'high' from codeine feels stronger. With only 60 mgs. He's sure that's not placebo effect. Although he knows that loperamide does not cross blood–brain barrier, he feels that loperamide potentiates codeine. The only problem is that he will have severe constipation today...
Just a personal experience...
Thank you!
Loperamide only increases CNS effects, including physical sedation. This is not a positve, really, and gut motility goes all to hell. Constipation for next few days at least.
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I agree, my friend reported not any increase of euphoria after both loperamide and loperamide+codeine dose.
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a couple days ago SWIM saw SWIT's post and decided to give it a try, so he did a CWE with 160mg of codeine (probably yielded about 135mg) and took 4mg of loperamide 20 minutes before taking the codeine and noticed absolutely no change at all. in SWIM's opinion it makes no difference at all (exept with the constipation).
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The 'high' from codeine feels stronger. With only 60 mgs. He's sure that's not placebo effect
[QUOTE=RoboCodeine7610;1190256]Yes it
Dear Robo, I have read most of your posts, specially on codeine, and I want you to know that I really appreciate your opinion, as a more experienced guy than my friend. But (there's always a but), how could it be placebo? I feel that there are placebo effects sometimes on benzos (as for anxious relief), but for opiates how you define 'placebo'? I mean, 'you feel them or not'. Anyway, my friend and me are not 100% sure that loperamide potentiates, specially on such low doses, maybe you are right.
After your response we started to think about it and if we exclude the loperamide, we are thinking that maybe those unexpected effects of that small dose of codeine, maybe caused fron an antacid (simethicone, not cimetidine) that he had consumed 3 hours ago! I did not mention it my last post, because simethicone was 3 hours ago and I didn't find it necessary... maybe it was from this...?
Thank you for your help
In this case, I define it as you thinking it was stronger when it really wasn't.
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maybe caused fron an antacid (simethicone, not cimetidine) that he had consumed 3 hours ago!
Simethicone is an anti-flatulent, not an antacid.Also, it's not absorbed into systemic circulation and is excreted unchanged in feces.You could argue that the simethicone aided in the absorption of codeine, but codeine is already almost completely absorbed from the intestine and therefore, it's impossible the simethicone actually did anything, which only reinforces my initial assumption that it was just placebo effect.
Think about it this way, 10 people see a murder and you get 10 slightly different stories.If normal perception is already that subjective, how subjective do you think drug effects are?
