Drug info - Dimethylaminorex, 4-DMAR, Direx

[chemman]

NAME:
(4S,5S) -trans-3,4-dimethyl-5-phenyl-1,3-oxazolidin-2-imine
trans-2-Imino-3,4-dimethyl-5-phenyloxazolidine
trans-dimethylaminorex
4-DMAR
Direx


trans-Dimethylaminorex is a long-lasting synthetic stimulant which is generally found in the form of either crystals or powder which are taken orally, smoked, or insufflated. It is often touted for its use as a work-drug, especially when writing or working on long projects. It is also noted for providing somewhat more euphoria than other stimulants such as MDPV or methamphetamine. In big dose is stimilar to MDMA or cocaine. Direx use has never been particularly widespread and the material is rarely seen on the street market.

chemman added 6 Minutes and 10 Seconds later...

CHEMISTRY


N-Carbamyl-ephedrine .Potassium cyanate (2 g., 0.025 mole) was added to ephedrine hydrochloride (5 g., 0.025 mole) in water (25 ml.), and the solution then refluxed for 24 hours, during which a small amount of oil separated, and cooled in ice-salt. The dried, white plates of the urea (3 g; 57.7%) were crystallised from ethyl acetate and then had m.p. 126-127 deg C.


trans-2-Imino-3,4-dimethyl-5-phenyloxazolidine hydrochloride:
A solution of N-carbamyl-ephedrine (1.56 g., 0-075 mole) in water (24 ml.) and 2N-hydro-
chloric acid (15 ml.) was refluxed for 3 hours; when the clear solution cooled the crude oxazolidine hydrochloride was obtained. This was purified by conversion into the base (use Na2CO3 or K2CO3) which was extracted with benzene. The solvent was removed under vacuum from this, and the residue (direx freebase) converted into the hydrochloride (1-9g.; 84%), m. p. 225-229.
You can also use freebase to smoke or oral consumption.

chemman added 4 Minutes and 38 Seconds later...

DOSE AND EFFECTS
A standard dose of dimethylaminorex seems to run between 5 and 15 mg regardless of ingestion method (oral, insufflated or smoked). Ingestion method primarily affects the duration of the experience with smoking providing the shortest duration and oral the longest.

Oral (HCl salt)
Light: 5-10 mg
Common: 10-17 mg
Strong: 16-30 mg

Onset: 45 min - 2 hours
Duration: 10-16 hours
Normal after effects: up to 36 hours

Insufflated (HCl salt)
Light: 4-10 mg
Common: 8-16 mg
Strong: 15-25 mg

Onset: 15-45 minutes
Duration: 4-10 hours
Normal after effects: up to 28 hours

Smoke: (freebase)
Light: 3-6 mg
Common: 5-15 mg
Strong: 15-25 mg

Onset: 1-5 minutes
Duration: to 10 hours
Normal after effects: up to 28 hours

LAW
Legal in Poland
Illegal in England and USA (designer analog of aminorex)

chemman added 1 Minutes and 44 Seconds later...

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Uffff. Polish Harder What do you think about my post?

Reputation Comments on this post:

	Thank you for the contribution
	Good and valuable information about an pretty much unknown substance.
	Interesting, thanks for all the info.
	This info was looked after for a long time. Thank you very much for posting it.
	good find..thanks
	Valuable contribution

[De Stijl]

I've never heard of this compound referred to as 4-DMAR or Direx, the usual shorthand is 3,4-DMAR. I haven't heard of it "often touted for its use as a work-drug, especially when writing or working on long projects" either.
In fact I can find very little information about it' but there are old hive posts flagging it as more toxic than aminorex. Aminorex got pulled after less than 2 years on the market in the sixties, hardly the age of health and safety, thanks to the number of people whose hearts where terminally fucked by it.

More toxic than that..,PASS.

[chemman]

Not many side effects. If you do a large amount for several days you can
get diareaha. Nothing too severe though.

[Quantum Dude]

Thank you very much for this info but could SWIM provide references about the compound pharmacology. Its very hard to find.